SLEEP 2011 Abstract Supplement

B. Clinical Sleep Science IX. Psychiatric and Behavioral Disorders and Sleep
Methods: A double-blind, randomized, placebo-controlled clinical trial
was performed with 60 depressed, insomniac outpatients receiving one
week of open-label fluoxetine, followed by 8 more weeks of fluoxetine
and either eszopiclone or placebo at bedtime. Patients underwent actigraphic
monitoring with sleep diaries over a continuous 10-week period.
After one week of baseline monitoring, subjects spent one night in the
laboratory with actigraphy monitoring and sleep diaries. At the end of 10
weeks, subjects underwent a second night of laboratory monitoring. Actigraphic
and diary sleep measurements for the weeks before and after
laboratory nights were compared with laboratory night measurements.
Results: Actigraphically recorded laboratory sleep during both nights in
the laboratory was found to be improved relative to sleep at home, with
less wake time and greater sleep time and sleep efficiency occurring in
the laboratory. In contrast, sleep diaries indicated a worsening of sleep
in the laboratory compared to home, with significantly more awakenings
and less sleep time on laboratory nights compared to the weeks at home.
Conclusion: Objective and subjective sleep measurements seen in depressed
insomniacs may be influenced by the monitoring setting and the
measurement modality.
Support (If Any): NIH MH70821 and M01-RR07122, as well as funding
and medications from Sepracor, and funding and material support
from Mini Mitter
0745
SUBJECTIVE, BUT NOT OBJECTIVE, SLEEP
DISTURBANCES ARE ASSOCIATED WITH AN INCREASED
RISK OF DEPRESSION IN OLDER MEN
Paudel ML 1 , Taylor BC 1,2,3 , Ancoli-Israel S 4 , Blackwell T 5 ,
Maglione JE 4 , Stone KL 5 , Redline S 6 , Ensrud KE 1,2,3
1
Division of Epidemiology and Community Health, University of
Minnesota-Twin Cities, Minneapolis, MN, USA, 2 Center for Chronic
Disease Outcomes Research, Veterans Affairs Medical Center,
Minneapolis, MN, USA, 3 Department of Medicine, University of
Minnesota-Twin Cities, Minneapolis, MN, USA, 4 Department of
Psychiatry, University of California-San Diego, La Jolla, CA, USA,
5
California Pacific Medical Center Research Institute, San Francisco,
CA, USA, 6 Department of Medicine and Division of Sleep Medicine,
Harvard University, Boston, MA, USA
Introduction: Depression and insomnia are common complaints in older
adults. Prior studies have suggested that subjective sleep disturbances
are associated with increased risk of recurrent and new onset depression,
but longitudinal relationships between objective sleep disturbances and
depression are uncertain.
Methods: Subjective sleep quality and daytime sleepiness were measured
in 2,510 non-depressed men aged 67 and older, enrolled in the
MrOS Sleep Study at baseline using the Pittsburgh Sleep Qualty Index
(PSQI) and Epworth Sleepiness Scale (ESS). Objective sleep was measured
at baseline using wrist actigraphy for an average of 112+18h. Depressive
symptoms were measured at baseline and an average of 3.4+0.5
years later, with the Geriatric Depression Scale(GDS) using the following
cut-points: 0-2(normal); 3-5(some depressive symptoms); >=6(depressed).
Results: Of the 2,510 men with GDS