SLEEP 2011 Abstract Supplement

B. Clinical Sleep Science XIII. Sleep and Gender
dependent of depressive symptoms. These findings have important clinical
implications inasmuch as they highlight the potential interpersonal
consequences of sleep disorders, such as insomnia.
Support (If Any): Support for the first author was provided by K23
HL093220. Additional research support provided by HL076852/
HL076858 and CTSA/N-CTRC #RR024153.
0923
COGNITIVE DEFICITS: RELATIONSHIP TO SLEEP AND
FATIGUE IN BREAST CANCER PATIENTS
Ancoli-Israel S, Natarajan L, Palmer B, Rissling M, Parker BA, Liu L
University of California San Diego, La Jolla, CA, USA
Introduction: Patients treated with chemotherapy complain of decreased
cognitive functioning before and during chemotherapy. This has
been termed “chemobrain.” Understanding the cause of chemobrain is
critical as these patients require increased care, experience impaired decision
making ability, experience decreased quality of life and express
concern about their ability to maintain employment. This study examined
whether the cognitive impairment associated with chemotherapy
might be secondary to fatigue and sleep.
Methods: Data from 71 women (Mean age=51.8 years; SD=9.7) are
presented. All were diagnosed with stage I-III breast cancer and were
undergoing chemotherapy. As a comparison, 53 age and educationmatched
women (Mean age=51.4 years; SD=9.6) with no history of
cancer were studied. Measures of subjective and objective cognitive
function, questionnaires on fatigue, sleep, mood, , and quality of life
(QOL) were administered the start (baseline) and after the cycle 4 (C4)
of chemotherapy. An actigraph was also worn at both points. Naps and
total sleep time were based on actigraphy.
Results: Compared to controls, patients napped significantly more, slept
less at night, and had worse depressive symptoms, fatigue, and worse
QOL at baseline and at C4 (all p15
without regard to ODI.
Results: Of 22151 men studied 12149(55%) men were 40-65 years.
Of the 12149 men, 7500(62%) were identified to have sleep disordered
breathing (AH+OSA=SDB). AH group accounted for 367/12149 (3%)
of the total and 367/7500 SDB (5%) of men ages 40-65. AH was characterized
by RDI< 10, nadir oxygen less than 85%, time below 90% >
10 minutes, ODI