SLEEP 2011 Abstract Supplement

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B. Clinical Sleep Science VIII. Medical Disorders and Sleep (87%) and cough or snoring (56.5%). In contrast, only 3.1% claimed having more than 9 hours of sleep a night. There was no correlation between sleep and glycemic control in these diabetics (r=0.038 p= 0.666). Conclusion: Patients with diabetes suffer from poor sleep quality. Majority of patients experience nocturia and cough during night time. 0666 A PILOT STUDY TO IDENTIFY GENETIC VARIATIONS OF RESTLESS LEGS SYNDROME IN PERSONS WITH TYPE 2 DIABETES Cuellar NG Capstone College of Nursing, University of Alabama, Tuscaloosa, AL, USA Introduction: Restless Legs Syndrome (RLS) is a highly heritable syndrome with an identifiable phenotype, variable expressivity, and high penetrance. RLS is reported in 44% of persons with type 2 diabetes (t2D). Genetic variations may impact the onset of RLS symptoms. The purpose of this pilot was to compare genetic variations of RLS in persons with t2D. Methods: This is a pilot study to examine a genome wide association, typing cases and controls on a single set of arrays. 41 patients with t2D were recruited from the PENN Rodebaugh Diabetes Center. Participants were screened using the telephone diagnostic interview for RLS. Data was collected on ferritin, glycosylated hemoglobin (HgA1c), and genetic testing (analyzed at the Molecular Diagnosis and Genotyping Facility at UPENN). Genetic variations for RLS were based on findings in literature 6-9 including: BTBD9 (rs9296249, rs9357271, rs3923809), MEIS1 (rs2300478), MAP2K5 (rs12593813, rs11635424, rs4489954, rs3784709, rs1026732), LBXOR1 (rs6494696), PTPRD (rs4626664). Results: Sample size was 41 (26 males; 15 females), mean age 64(SD=9.8). Participants with RLS were younger, had higher HgA1c and lower ferritin levels. One SNP on the MAP2K5 gene at locus rs3784709 was different between the 2 groups (p=0.005) with C risk allele on locus rs3784709 more frequently identified in persons with RLS than those without. Limitations of the study include sample size. as we did not have power based on odds ratio and allele frequency to detect associations with the SNPs. Conclusion: It is uncertain why some people with t2D may develop RLS and others do not if the genetic variations are no different between the two groups. The progression of RLS after the diagnosis of t2D warrants further investigation. Studies examining the genetic variation of RLS and the association with t2D may improve diagnosis and treatment of RLS and t2D. Support (If Any): 1) Hartford Center of Geriatric Nursing Excellence and the Frank Morgan Jones Fund at the University of Pennsylvania School of Nursing, Philadelphia 2) Public Health Services Research Grant RR024134 from the National Institutes of Health 0667 CHARACTERIZING THE RELATIONSHIP SHARED BY SLEEP DISORDERS AND DIABETES Seibert PS 1,2 , Schommer J 1 , Gagnon S 1,2 , Connely M 1,2 , Grimsley F 1 1 Saint Alphonsus Regional Medical Center, Boise, ID, USA, 2 Boise State University, Boise, ID, USA Introduction: Research has demonstrated that sleep disorders (SDs) are associated with prolific health problems. The extent of these relationships has not been clearly ascertained because of significant rates of under or inadequate diagnoses along with a multitude of intervening variables associated with disease symptomatology. Investigations are further constrained by difficulty in acquiring valid data from people whose diagnoses are based on a complete nocturnal polysomnography (NP) and/or multiple sleep latency tests (MSLT). Researchers are beginning to examine relationships shared by SDs and diabetes to illuminate relevant covariance. It is estimated that 23.6 million people in the United States have diabetes and an additional 57 million people have pre-diabetes. Daily self-management is essential for controlling diabetes and its associated complications. Comorbidity of diabetes with SDs may present unique challenges for daily self-management because SDs may compromise cognition, emotional well-being, and general health. Methods: We constructed an 111-item questionnaire to use in conjunction with nocturnal polysomnography studies (NPS), multiple sleep latency tests, the Epworth Sleepiness Scale (ESS), and medical chart reviews of people referred for evaluation of SDs. Results: We analyzed data from 658 people (290 female, 368 males). 101 had a history of diabetes and were diagnosed with SDs. Analyses of the diabetes versus no diabetes groups provided characterizations of those with SD and diabetes. For example, comparisons of the groups during NPS revealed significant differences in prevalence of diagnoses of poor sleep efficiency and nocturnal hypoxemia. People with diabetes had higher BMI; slept fewer hours; spent more time in stage 1 sleep and less in stages 3 and 4; reported greater incidents of pain, depression, high blood pressure, heart failure, heart attack, chronic lung disease, thyroid disease, stroke, and bed wetting. Conclusion: We hope identification of diabetes risk/predictor variables associated with SD will contribute to facilitating prevention, early diagnosis, and effective treatment modalities. 0668 PREVALENCE OF VITAMIN D INSUFFICIENCY/ DEFICIENCY AMONG SLEEP MEDICINE PATIENTS COMPLAINING OF SOMATIC PAIN AND CORRELATION WITH DAYTIME SLEEPINESS McCarty DE, Reddy A Neurology/Sleep Medicine, LSUHSC-Shreveport, Shreveport, LA, USA Introduction: Vitamin D deficiency/insufficiency (VDDI) affects > 1 billion persons worldwide, predisposing to nonspecific musculoskeletal pain and painful myopathy. Vitamin D levels are inversely correlated with systemic inflammatory markers. Chronic pain and systemic inflammation contribute to sleep disruption and daytime impairment symptoms, including excessive daytime sleepiness (EDS), though the potential contribution of VDDI to these problems in a sleep medicine population has not been systematically investigated. We postulated that VDDI may be highly prevalent amongst sleep medicine patients complaining of pain, and sought to determine whether there is a correlation between 25-hydroxyvitamin D level and EDS. Methods: Consecutive patients evaluated at an academic sleep disorders center from 4/1/08 to 3/31/09 were questioned about the presence of musculoskeletal pain. 69 patients who answered in the affirmative, and who agreed to VDDI screening via venous sampling, were included. Epworth Sleepiness Scale scores (ESSS) were analyzed if obtained within 2 weeks of the blood test. Vitamin D deficiency was defined as a 25-hydroxyvitamin D level of
B. Clinical Sleep Science VIII. Medical Disorders and Sleep 0669 RELATIONSHIP BETWEEN INSOMNIA, PAIN SENSITIVITY AND PAIN INHIBITION IN OLDER ADULTS WITH AND WITHOUT KNEE OSTEOARTHRITIS Park R, Buenaver LF, Campbell C, Nasir A, McCauley L, Smith MT Psychiatry and Behavioral Sciences, Johns Hopkins University, Baltimore, MD, USA Introduction: Quantitative sensory testing (QST) suggests that osteoarthritis patients demonstrate generalized hyperalgesia and impaired endogenous pain inhibitory capacity, but the correlates of these sensory alterations are poorly understood. The present investigation examines whether insomnia may be associated with hyperalgesia and reduced pain inhibition in osteoarthritis (OA). Methods: In this quasi-experimental study, we used polysomnography and knee radiography to carefully diagnose 4 groups of older adults according to research diagnostic criteria for sleep and knee osteoarthritis. We compared standardized indices of pressure pain threshold (PPT) and pain inhibition in 100 participants meeting criteria for: 1) Normal-Sleep/ No-OA (n=22); 2) Normal-Sleep/+OA (n= 14); 3) Primary-Insomnia/ No-OA (n=15) and 4) Insomnia/+OA (n=49). Baseline PPT was measured bilaterally via algometry at the trapezius. Pain inhibition was assessed via a diffuse noxious inhibitory control (DNIC) paradigm quantifying percent change in trapezius PPT from baseline relative to trapezius PPT assessed during contra lateral hand immersion in a 4°C, circulating ice water bath (DNIC index). Results: ANOVA s demonstrated a significant omnibus effect for group status on both PPT and DNIC (p
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JOURNAL OF SLEEP AND SLEEP DISORDER
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EDITORIAL In June of 1986, roughly
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