SLEEP 2011 Abstract Supplement

B. Clinical Sleep Science XI. Pediatrics
Methods: All subjects underwent overnight polysomnography (PSG). A
retrospective review of records and sleep questionnaires was conducted.
Subjects with Medicaid insurance were classified as low socioeconomic
status (SES). OSA was diagnosed if Respiratory Disturbance Index
(RDI) was ≥ 5 events/hr.
Results: Of 72 subjects (mean age 17.3 ± 1.3 yrs, mean BMI 45.6 ± 6.0
kg/m2) 24% were African Americans, 25% Hispanics and 51% Caucasians.
24% of subjects were of low SES. The prevalence of OSA was
24%. Subjects with OSA had a mean RDI of 12.1± 11.4 events/hr. By
questionnaire, only snoring incidence was higher (94% vs. 66%, p =.03)
in OSA vs. non OSA group by Fischer’s Exact Test. The logistic model
showed both BMI and gender are significant predictors of OSA in adolescents
with high BMI at higher risk for OSA (OR=1.2; p=0.0024) and
females at lower risk (OR=0.09; p=0.0007). Fasting serum insulin levels
were higher in the OSA group (21.9 ± 8.9 vs. 13.9 ± 12.3 uI/ml p = .02)
based on Two-sample t-test but there were no differences in fasting glucose
levels suggesting insulin resistance is associated with OSA in the
absence of alteration in glucose tolerance. Controlling for BMI, covariates
including ethnicity and SES were marginally significant predictors
of OSA while diabetes, hypertension, metabolic syndrome were not.
Conclusion: The prevalence of OSA in adolescents undergoing evaluation
for LAGB, although lower than reported in adults, is high. OSA was
poorly predicted by clinical parameters.
0872
PREVALENCE OF RESTLESS LEG SYNDROME AMONG
ADOLESCENT CHILDREN IN THE TUCSON CHILDREN’S
ASSESSMENT OF SLEEP APNEA STUDY (TUCASA)
Goodwin J 1,2 , Vasquez MM 1 , Quan SF 1,2,3
1
Arizona Respiratory Center, University of Arizona, Tucson, AZ,
USA, 2 College of Medicine, University of Arizona, Tucson, AZ, USA,
3
Division of Sleep Medicine, Harvard Medical School, Boston, MA,
USA
Introduction: Restless Leg Syndrome (RLS) and it’s association with
sleep problems in a general population of adolescents has been understudied.
This analysis aims to describe the prevalence of RLS, and its
association with sleep problems, in the adolescent age group.
Methods: The TuCASA study is a prospective, cohort study that initially
enrolled Hispanic and Caucasian children between the ages of 6
and 11 years and subsequently re-studied them about 5 years later at
approximately 10-18 years of age. At the time of the 2nd examination,
in-home polysomnography as well as a comprehensive sleep habits survey
including questions pertaining to RLS were completed. RLS was
present if the subject met 4 essential adult RLS criteria described by
Allen et al (2003). Habitual snoring (SN), excessive daytime sleepiness
(EDS), difficulty initiating or maintaining sleep (DIMS), and learning
problems (LP) were present if symptoms were endorsed frequently or
almost always. Enuresis (EN), sleep terrors (TR), sleep walking (SW)
and sleep talking (ST) were also assessed.
Results: Assessments were obtained in 348 children (49% girls; 36%
Hispanic). The prevalence of RLS was 4.3%. RLS was associated with
the presence of EDS (p< 0.006), DIMS (p< 0.013), and SN (p< 0.029).
Although the prevalence of RLS was higher in girls than boys (5.3% vs
3.4%), this did not achieve statistical significance. There was no association
between RLS and ethnicity, LP, EN, SW, or ST.
Conclusion: The prevalence of RLS in a community based sample of
adolescents is approximately 4.3%. RLS in adolescents is associated
with EDS, DIMS, and habitual snoring.
Support (If Any): HL 62373
0873
EFFECT OF AGE, GENDER AND IRON DOSING ON
SYMPTOMATOLOGY AND FERRITIN LEVELS IN
CHILDREN WITH RESTLESS LEG SYNDROME
Bhagavatula G 1,2 , Chalanick K 2 , Carno M 1,2,3 , Connolly HV 1,2
1
Pediatrics, University of Rochester, Rochester, NY, USA, 2 Pediatric
Sleep Meidicne, University of Rochester, Rochester, NY, USA, 3 School
of Nursing, University of Rochester, Rochester, NY, USA
Introduction: Serum ferritin level< 50ng/mL, indicative of low iron
bio-availability, is associated with the presence of symptoms of restless
leg syndrome (RLS). Treatment with iron to increase serum ferritin
above 50ng/mL reduces these symptoms. The purpose of this study was
to assess response to oral iron in children with low ferritin levels and
symptoms of RLS.
Methods: Retrospective chart review of 238 patients with serum ferritin
level obtained at a large regional pediatric sleep lab from 6/28/2007-
3/30/2010. Symptomatology and ferritin levels were analyzed for
changes before and after treatment with oral iron (n=64) as was data
from polysomnography (n=201).
Results: There was a correlation between age and initial ferritin level
(r= -0.295, p