SLEEP 2011 Abstract Supplement

B. Clinical Sleep Science XII. Sleep and Aging
0886
DIFFICULTY MAINTAINING SLEEP AND EARLY WAKE-UP
TIMES ARE ASSOCIATED WITH VASCULAR DYSFUNCTION
IN JAPANESE HEALTHY INDIVIDUALS
Kadono M 1 , Shigeta M 2 , Hasegawa G 1 , Asano M 1 , Yamazaki M 1 ,
Fukui M 1 , Nakamura N 1
1
Endocrinology and Metabolism, Kyoto Prefectural University of
Medicine, Kyoto, Japan, 2 Department of Epidemiology for Community
Health and Medicine, Kyoto Prefectural University of Medicine,
Kyoto, Japan
Introduction: Introduction: Previous investigations have shown sleep
loss causes hypertension and atherosclerosis. Sleep fragmentation and
earlier wake-up times characterize sleep patterns of older adults. Taken
together, vascular dysfunction with aging could be associated with
the age- related changes of sleep-wake patterns in forms of difficulty
maintaining sleep and waking-up early . In the present study, we have
cross-sectionally investigated whether self- reported difficulty sleep
maintaining and habitual wake-up times are associated with higher
blood pressure and vascular dysfunction.
Methods: The current study included 2062 apparently healthy individuals
(mean aged 57.2±10.1, 1074 male)who underwent general
health screening test in a general hospital. Habitual patterns concerning
sleep (bed times, wake-up times, and symptoms of difficulty initiating
or maintaining sleep) on weekdays were recorded from answers on the
questionnaire. Vascular condition was assessed by blood pressure and
brachial-ankle pulse-wave velocity (PWV) value. Hypertension was
defined as blood pressure ≥130/85 mmHg,and atherosclerosis was determined
as the highest tertile of baPWV values. Multivariate logistic
regression model, adjusted for variables including gender, age, sex, body
mass index, blood pressure, sleep duration were applied.
Results: Difficulty maintaining sleep was associated with increased
prevalence of hypertension with adjusted odds ratio of 1.23(1.01-1.50).
Wake-up times before 5:00 a.m. were associated with increased prevalence
of hypertension and atherosclerosis with an adjusted odds ratio of
1.48(1.06-2.07) and 1.83(1.12-2.99), respectively, compared to wake-up
times after 5:00 a.m. Adjusting for sleep duration did not contribute to
the association between difficulty maintaining, early waking, and vascular
condition.
Conclusion: Difficulty maintaining sleep and early wake-up times were
strongly associated with vascular dysfunction. Age- associated sleep
forms might influence vascular condition.
0887
MILD COGNITIVE IMPAIRMENT IN OLDER ADULTS IS
NOT ASSOCIATED WITH SIGNIFICANT SUBJECTIVE
SLEEP DISTURBANCE
Vitiello MV 1,2,3 , Barsness SM 1 , Baker LD 1 , Merriam GM 2 , Borson S 1
1
Psychiatry and Behavioral Sciences, University of Washington,
Seattle, WA, USA, 2 Medicine, University of Washington, Seattle, WA,
USA, 3 Biobehavioral Nursing, University of Washington, Seattle, WA,
USA
Introduction: The disturbed sleep of Alzheimer’s disease (AD) patients
has been well characterized even in early stages of the disease. Mild
Cognitive Impairment (MCI) in older adults has recently been recognized
as a pro-dromal phase of AD, opening the question of whether the
sleep disturbances that characterize early stage AD might be present in
MCI patients. To address this question we compared the subjective sleep
quality of a group of amnestic MCI (aMCI) patients with a control group
of healthy normal older adults.
Methods: Fifty-seven aMCI patients (age 70.5 + 1.1 years (mean +
SEM); 22 men and 35 women) and 69 Controls (age 66.3 + 0.9 years;
30 men and 39 women) completed the Pittsburgh Sleep Quality Index
(PSQI) as part of the baseline assessment of an ongoing randomized
controlled trial. Groups were carefully screened to exclude major medi-
cal conditions and primary sleep disorders and had similar levels of education
and comparable body mass indices.
Results: aMCIs did not report more subjective sleep disturbance than
Controls for either PSQI total (5.7 + 0.4 versus 5.4 + 0.4, respectively)
or subscale scores. Women tended to have higher PSQI scores than men,
regardless of diagnosis, although such differences were also non-significant.
Conclusion: Older adults with aMCI do not report significantly impaired
subjective sleep quality relative to healthy older controls; despite
the older age of the aMCIs potentially biasing in favor of more impaired
sleep quality in that group. These findings indicate that, while MCI may
be a pro-dromal phase of AD, either the changes in cognitive function,
particularly memory, which are the hallmark of AD, occur sooner than
changes in sleep quality, or that objective changes in sleep patterns, not
measured in the current study, are not of sufficient magnitude to be reliably
perceived by aMCI patients.
Support (If Any): R01-AG025515 (MVV)
0888
DIFFERENCE IN LIPID PEROXIDATION
CONCENTRATIONS IN ADULTS AND ELDERLY PATIENTS
WITH OBSTRUCTIVE SLEEP APNEA SYNDROME (OSAS)
Yagihara F, Lucchesi L, D’Almeida V, Sales L, Tufik S, Bittencourt LA
Departamento de Psicobiologia, Universidade Federal de São Paulo,
São Paulo, Brazil
Introduction: The aging process and intermittent hypoxia observed in
obstructive sleep apnea syndrome (OSAS) may lead to an increase in
the generation of reactive oxygen species and to an increase in malondialdehyde
(MDA) plasma concentrations. Studies that compare lipidic
peroxidation in elderly and adult people with OSAS are scarce. Our aim
was to evaluate the effect of age upon lipid peroxidation concentrations
in adult and elderly men with OSAS.
Methods: Male volunteers with ages between 25 and 75 years old were
selected. Their body mass index (BMI) was under 40 kg/m2, and they
had a clinic and polysomnographic diagnosis of OSAS. Each OSAS
group had its own control group. They underwent blood analysis for
lipid peroxidation evaluation.
Results: Participants were divided into four groups: 13 adults with
OSAS, 12 adult controls, 30 elderly OSAS and 27 elderly controls. According
to apnea-hypopnea index (AHI), as expected, there were significant
intra-group differences both in the adult group [controls: 5.7 (95%
3.1-14.4) vs. OSAS=40.6 (95% 30.4-50.8)], and in the elderly group
[controls:1.8 (95% 8-11.6) vs. OSAS=36.5 (95% 27.4-45.5)]. The elderly
group with apnea had a higher mean MDA in relation to the elderly
control group [2.9 nmol MDA/mL (95% 2.2-3.6) vs. 1.5 nmol MDA/mL
(95% 0.9-2.2) respectively] and the adult apnea group [2.9 nmol MDA/
mL (95% 2.2-3.6) vs. 1.5 nmol MDA/mL (95% 0.8-2.2) respectively].
There were no differences between the elderly apnea and the adult control
groups [2.9 nmol MDA/mL (95% 2.2-3.6) vs. 2.1 nmol MDA/mL
(95%1.4-2.8), respectively].
Conclusion: In our study we observed that in comparison with adults
and controls, the elderly group with OSAS was influenced by two additive
effects of oxidative stress, aging and OSAS, as suggested by the
increase of lipid peroxidation.
Support (If Any): AFIP, FAPESP/ CEPID and CNPq
A303
SLEEP, Volume 34, Abstract Supplement, 2011