SLEEP 2011 Abstract Supplement

B. Clinical Sleep Science VIII. Medical Disorders and Sleep
0695
ANGIOTENSIN CONVERTING ENZYME POLYMORPHISM
AND ERECTILE DYSFUNCTION COMPLAINTS IN
THE BRAZILIAN POPULATION: DATA FROM A SLEEP
DISORDER SURVEY
Andersen ML, Guindalini C, Santos-Silva R, Bittencourt LA, Tufik S
Psicobiologia, UNIFESP, Sao Paulo, Brazil
Introduction: Erectile dysfunction (ED) is increasingly recognized as a
public health problem. Indeed, ED or sexual complications are common
in men with cardiovascular disease and both diseases have overlapping
risk factors, etiology and clinical outcomes. Angiotensin-converting
enzyme (ACE) is the major regulator of circulatory homeostasis. An
insertion-deletion polymorphism in the ACE gene has been associated
with marked differences in serum ACE levels and with various cardiovascular
diseases. We sought to evaluate a potential association between
ACE polymorphisms and ED complaints and its relationship with sleep
disorders in a population-based sample in São Paulo, Brazil.
Methods: A total of 449 men were enrolled in the Epidemiologic Sleep
Study (EPISONO) and answered an 8-item questionnaire to ascertain
sexual performance/ED and satisfaction. ACE polymorphisms were
genotyped using a standard polymerase chain reaction method.
Results: No significant case-control difference was observed for the
ACE I/D polymorphism either by genotype or allele-wise. The inclusion
of Obstructive Sleep Apnea Syndrome (OSAS) diagnosis in the analyses
did not provide evidence of an association with ED phenotype or with
OSAS itself. Because age is a significant risk factor for ED complaints
in our sample, we carried out analyses stratifying the sample by age
group. The ID and II genotypes were significantly more frequent in ED
complaint cases (88.9%) compared to controls (57.1%) in the men between
40 and 55 years of age. The frequency of the I allele was also significantly
higher in individuals complaining of ED (66.7%) compared to
men with no complaints (39.0%) (OR=3.12; 95%IC=1.48-6.59). Correction
for potential confounding variables, including genetic ancestry,
did not affect the strength of the association.
Conclusion: The findings of the present study suggest that the I/D
polymorphism or another variant in close linkage disequilibrium with
it may play a role in the development of ED in a specific age group and
provides progress towards the understanding of the interaction between
genetic factors, sleep and the risk of ED.
Support (If Any): AFIP, FAPESP/CEPID, CNPq.
0696
DAYTIME PULSE-OXIMETRY MEASUREMENTS DO NOT
PREDICT NOCTURNAL DESATURATIONS IN ADULT
SICKLE CELL PATIENTS
Kadali RA 1 , Chohan HS 1 , Efird J 1 , Boettger P 2 , Liles D 2 , Knupp C 2 ,
Judy JS 1 , Sharma S 1
1
Sleep Disorders and Research Center, Division of Pulmonary, Critical
Care and Sleep Medicine, Department of Internal Medicine, Brody
School of Medicine, East Carolina University, Greenville, NC, USA,
2
Division of Hematology and Oncology, Department of Internal
Medicine, Brody School of Medicine, East Carolina University,
Greenville, NC, USA
Introduction: Low nocturnal saturations in sickle cell patients have
been associated with increase pain crisis and first cerebrovascular accident.
This study evaluated the relationship of daytime pulse-oximetry
and nocturnal desaturations in adult sickle cell disease (SSD).
Methods: Retrospective analysis of 43 patients referred from sickle
cell clinic. Inclusion criteria were presence of Hemoglobin SS (homozygous),
age >21, overnight pulse-oximetry or overnight sleep study.
Nocturnal desaturation was defined as spending >5 mins below 89% at
night. Daytime saturations were considered normal if > 95%. Patient’s
baseline characteristics were documented. Fisher’s exact test was used
for comparing the normal and low daytime saturation groups.
Results: Of the 43 patients identified, 16 did not meet inclusion criteria.
The mean age of the group was 40 (22-65). Of the 27 patients,
17 (63%) had normal daytime saturations (>95%) and 10 (37%) had
low daytime saturations (95% or less). 6/10 (60%) of patients with low
daytime saturation had nocturnal desaturation compared to 7/17 (41%)
in the normal saturations group (p=0.44). Baseline characteristics were
similar between groups. When compared with a random group with
good daytime saturations, the sickle cell group with normal daytime
saturations demonstrated significant oxygen desaturations (p