SLEEP 2011 Abstract Supplement

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B. Clinical Sleep Science VI. Sleep Disorders – Hypersomnia Results: Compared to subjects with EDS, NC patients presented a homogenous BMI, significantly higher waist circumference (p=0.002), waist to hip ratio (p=0.012), fasting insulin (p=0.034) and a lower HDL cholesterol (p=0.019). NC also presented an higher prevalence of MS (p=0.002). Compared to OSAS subjects, NC patients with OSA presented a homogeneous BMI, a significantly lower HDL (p=0.02) and higher fasting insulin (p=0.03). There was no difference in MS prevalence. Family history did not play a role in any comparisons. Conclusion: Compared to subjects without any sleep disorder, NC shows a significantly altered glucose and lipid profile and an increased presence of MS. When co-morbidity with OSA is included, NC patients still show more altered metabolic profile than OSAS patients, though MS presence is comparable. 0615 PERSISTENT HYPOTONIA WITH COMPLEX MOVEMENT DISORDER IN CHILDHOOD NARCOLEPSY-CATAPLEXY AT DISEASE ONSET Pizza F 1 , Palaia V 1 , Franceschini C 1 , Poli F 1 , Kaveh Moghadam K 1 , Mignot E 2 , Bhatia KP 3 , Plazzi G 1 1 Department of Neurological Sciences, University of Bologna, Bologna, Italy, 2 Center for Narcolepsy, Stanford University School of Medicine, Palo Alto, CA, USA, 3 Sobell Department of Motor Neuroscience and Movement Disorders, UCL Institute of Neurology, Queen Square, London, United Kingdom Introduction: Narcolepsy with cataplexy (NC) is characterized by daytime sleepiness, cataplexy, sleep paralysis, hypnagogic hallucinations and disturbed nocturnal sleep. NC is associated to the loss of hypothalamic hypocretin-1 producing neurons and to the HLA-DQB1*0602 haplotype with evidence of autoimmune etiology. Methods: In 31 children with NC (17 males, mean age of 12±3.4 years), motor phenomena were documented by means of video recordings at baseline and during emotional stimuli (cartoons watching). The occurrence of “negative” (paroxysmal head drops and falls, persistent eyelid narrowing and tongue protrusion, persistent facial hypotonia, persistent generalized hypotonia) and of “active” (raising of the eyebrows, perioral and tongue movements, facial grimaces, swaying of the head and/or trunk, stereotyped motor behaviors, dyskinetic or dystonic movements) motor features were assessed with a semi-quantitative approach. The “negative” and “active” composite score was related with age at NC onset, disease duration, MSLT features, cerebrospinal hcrt-1 and antistreptolysin-O (ASO) titres (Pearson’s correlations). Results: Our patients showed frequently occurring “negative” and “active” motor phenomena, associated with evidence of hypotonic features at neurological examination, and significantly enhanced by emotional stimuli (p
B. Clinical Sleep Science VI. Sleep Disorders – Hypersomnia Results: NC patients showed an higher prevalence of SRED (37% vs 0%, p
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JOURNAL OF SLEEP AND SLEEP DISORDER
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EDITORIAL In June of 1986, roughly
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A. Basic Science I. Pharmacology an
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