SLEEP 2011 Abstract Supplement

B. Clinical Sleep Science XII. Sleep and Aging
cility-level predictors of bright light and interventions to increase bright
light exposure in a variety of settings, including PAR, are needed.
Support (If Any): VA HSR&D (Project # IIR 04-321) and NIH/NIA
K23 AG028452
0892
MINIMAL COGNITIVE IMPAIRMENT IN THE ELDERLY
WITH SLEEP APNEA SYNDROME
Ju G 1 , Yoon I 1 , Lee S 1 , Kim K 1 , Kim J 2
1
Neuropsychiatry, Seoul National University Bundang Hospital,
Seongnam, Republic of Korea, 2 Otorhinolaryngology Head and Neck
Surgery, Seoul National University Bundang Hospital, Seongnam,
Republic of Korea
Introduction: Cognitive functions are known to be impaired in the
middle-aged with sleep apnea syndrome (SAS), but the relation between
cognitive dysfunction and SAS in the elderly has yet to be decided. The
aim of the current study was to investigate whether SAS may result in
cognitive decline in elderly subjects.
Methods: Sixty five elderly subjects (29 women, 36 men; mean age,
68±4.7 years) participated in the study. None of the subjects had been
diagnosed or treated for SAS. All the subjects underwent polysomnography
and comprehensive cognitive function test. Subjects without SAS
(AHI30, n=21) SAS were compared for the attention, memory
and executive function.
Results: No difference was observed among three groups in all the measures
of attention, memory and executive function except delayed recall.
Daytime sleepiness was not different across the groups, either. There
was no correlation between cognitive functions, and polysomographic
variables or daytime sleepiness. Delayed recall was impaired in subjects
with severe SAS, followed by subject with mild to moderate SAS compared
to subjects without SAS (p=.016). The time of trail making test A
tended to be different among three groups (p=.072) with being longest
in severe SAS.
Conclusion: In the present study, we found that SAS had minimal impact
on cognitive function in the elderly population. The sequela of hypoxia
and respiratory disturbances in SAS might be less prominent in
the elderly than in middle-aged population. The findings need to be corroborated
with larger samples.
0893
LONGITUDINAL STUDY ON MENTAL HEALTH AND AGING:
THE EVOLUTION OF SLEEP QUALITY
Lorrain D 1,2 , Desjardins S 3 , Vigneault M 2,6 , Préville M 4 , Bélisle D 2,5
1
Psychology, University of Sherbrooke, Sherbrooke, QC, Canada,
2
Research Centre on aging, CSSS-IUGS, Sherbrooke, QC, Canada,
3
Psychology, UQTR, Trois-Rivières, QC, Canada, 4 Social medecine,
University of Sherbrooke, Sherbrooke, QC, Canada, 5 Letters and
communications, University of Sherbrooke, Sherbrooke, QC, Canada,
6
CUFG, University of Sherbrooke, Sherbrooke, QC, Canada
Introduction: Sleep quality tends to decrease as we age, mainly due
to typical sleep architecture modifications, sometimes complicated by
other physiological conditions, like primary insomnia. The incidence of
depression and/or anxiety disorder is also high in this population. The
goal of this study was to establish if the presence of a mental health condition
could influence the evolution of sleep quality during a one-year
period in elderly subjects.
Methods: Participants were 2182 adults (M age=74.8, SD=6.01 years)
(40.9 % men, 59.1% women) selected from a probabilistic sample composed
of aging individuals living at home in three different areas of the
province of Québec. They participated in a longitudinal study held from
2005 to 2008. The inclusion criteria’s were: being older than 65 years
old, understanding and speaking French and having no diagnostic of
cognitive disorders. The interview was held at the residence of the par-
ticipants and had an average length of 90 minutes. The DIS (Diagnostic
Interview Schedule) was used to evaluate the presence of depression or
anxiety symptoms in the last 12 months, whereas the PSQI (Pittsburg
Sleep Quality Index )was used to measure sleep quality (Buysse, 1989).
Data were collected twice, with an interval of one year.
Results: The mental health status examination revealed that 3.8% of the
participants met the diagnosis for anxiety disorder and 5.6% met the diagnosis
for depression. Of these, 37% reported taking a sleep medication
more than 3 times a week compared to 16.9% of those having no mental
health problem. Forty-nine percent of the subjects had a score higher
than 5 on the PSQI at time 1. Of participants initially having no sleep issues,
32.1% reported a decrease in sleep quality after one year. Paradoxically,
for subjects initially reporting sleep issues and having at least one
mental health condition, an increase in sleep quality was observed for
38.8% of them, while only 8.3% did continue to deteriorate. A multiple
regression revealed that the factors related to mood state, anxiety, use
of hypnotics, sex and age contributed to explain 33.6% of the variance.
Conclusion: The presence of insomnia symptoms is often associated
with a certain psychological distress. The consequence is a significant
decrease of subjective sleep quality. However, while aging and mental
health problems are associated to a decrease in sleep quality, the cooccurrence
of both is not to be readily interpreted as having a long lasting
synergistic effect.
Support (If Any): Research supported by the Canadian Institute of
Health Research.
0894
METABOLIC SYNDROME AND RISK OF OBSTRUCTIVE
SLEEP APNEA (OSA) IN THE ELDERLY
Mabry JE 1 , Herbert WG 1 , Myers J 2 , Dalman RL 3 , Powell A 2
1
Laboratory for Health and Exercise Science, Virginia Tech,
Blacksburg, VA, USA, 2 Veterans Affairs Palo Alto Health Care
System, Palo Alto, CA, USA, 3 Division of Vascular Surgery, Stanford
University Medical Center, Stanford, CA, USA
Introduction: Metabolic syndrome (MetSyn) is the clustering of central
obesity, insulin resistance, hypertension, and dyslipidemia. Important
consequences include increased risk of cardiovascular disease and type
2 diabetes (T2DM) (AHA Circulation 2004). Obstructive sleep apnea
(OSA) may contribute to development of MetSyn and subsequently to
T2DM through inflammation exacerbated by chronic intermittent hypoxia
and sleep fragmentation associated with OSA. However, this complex
relationship remains to be elucidated (Tasali et al. Am Thorac Soc
2008, Vol.5). Thus, we examined influences of OSA risk in the elderly
relative to constituent biomarkers of MetSyn.
Methods: Subjects were 328 free-living individuals from the Stanford
AAA STOP study (Abdominal Aortic Aneurysm: Simple Treatment or
Prevention). Each completed the Berlin Questionnaire to classify for
OSA risk (Low-risk, n=158; High-risk, n=170). Clinical tests were administered
to assess status on biomarkers of MetSyn, including central
obesity, insulin resistance, glucose intolerance, dyslipidemia and elevated
blood pressure (AHA Circulation 2004).
Results: Findings on a substantial subset of these subjects (n=113) suggest
that up to 96% were receiving anti-lipemic and/or anti-hypertensive
medications; approximately 8% also had a diagnosis of T2DM. Low- vs.
High-OSA risk groups were similar for gender (86% vs. 83% male) but
differed on age (Mean±SD=74.8±8.5 vs. 72.0±8.4 yr; p