SLEEP 2011 Abstract Supplement

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A. Basic Science III. Ontogeny/Aging relations with diary or PSQ scales. Total intracranial, cortical, and white matter volumes did not vary with age and gender. The hippocampus was bilaterally correlated with Ex (Right: R2=-.703, Left: R2=-.661 ), and the left hippocampus correlated with In (R2=-.575). Actigraphy and diary-reported TST correlated with right hippocampal volume (R2=.523, R2=.505, respectively), with no correlation with PSQ scales. Hierarchical regression analyses revealed that actigraphy TST partially mediated the relationship between Ex and hippocampal volume. Conclusion: Sleep measures are associated with hippocampal volumes, suggesting that it may mediate, or at least contribute to the relationship between behavioral problems and hippocampal function, in at-risk children. Support (If Any): R37 AA007065-22S1, NIH-NIAAA R01 DA027261, NIH-NIDA 0061 AGE-RELATED DIFFERENCES IN THE EFFECT OF CHRONIC <strong>SLEEP</strong> RESTRICTION ON <strong>SLEEP</strong> QUALITY Silva EJ 1 , Cain SW 1,2 , Munch MY 1,2 , Wang W 1,2 , Aeschbach D 1,2 , Ronda JM 1,2 , Czeisler CA 1,2 , Duffy JF 1,2 1 Division of Sleep Medicine, Brigham and Women’s Hospital, Boston, MA, USA, 2 Division of Sleep Medicine, Harvard Medical School, Boston, MA, USA Introduction: Changes in the interaction of circadian and sleep-wake homeostatic regulatory processes have been reported to result in increased vulnerability to sleep disruption in older adults, suggesting chronic sleep deficiency associated with aging may in part be due to circadian misalignment. We tested the hypothesis that under conditions of chronic sleep restriction (CSR), the sleep of older adults will be disrupted when scheduled at adverse circadian phases, while that of young adults will remain consolidated. Methods: 12 healthy older (mean±sd 59.6±4.5 yrs; 6f) and 12 healthy young (22.8±2.3; 6f) adults participated in a 39-day study. After spending 10h/night time in bed (TIB) at home for 3 weeks, the inpatient study began with six 24h baseline days (10-16h TIB/day), followed by 3 weeks of CSR-forced desynchrony, during which subjects lived on 28h “days” (6.53h TIB/28h, equivalent to 5.6h TIB/24h) with sleep episodes beginning 4h later each CSR-day. Core body temperature data were collected throughout to assess circadian phase. Polysomnography data were recorded throughout and scored in 30-sec epochs. Sleep data were binned into 60° circadian phase bins. Sleep efficiency (SE, total sleep time/TIB) during CSR was analyzed via mixed model analysis with fixed effects for AGE and PHASE. Results: There was a significant effect of AGE (p
A. Basic Science III. Ontogeny/Aging Results: Overall total sleep duration (598 +4.9 minutes, mean ±SEM) did not change from early adolescence to adults. Nevertheless, during early adolescence, NREM sleep duration increased from P23 (449 ±12.9) to P29 (485 ±10.7, P=0.04) while REM sleep duration decreased (130 ±5.2 to 106 ±3.3, P
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