SLEEP 2011 Abstract Supplement

B. Clinical Sleep Science III. Sleep Disorders – Insomnia
improved sleep latency, wake after sleep onset, and proportion of nights
on which “Did you sleep well last night?” was answered with “Yes”
more than P did. Z and LY3 improved the Assessment of Sleep Questionnaire
(ASQ) sleep experience domain more than P did. Z improved
the ASQ Feeling Upon Awakening domain more than P did. Evening
questionnaires: no treatment differences were found with the Daytime
Consequences of Insomnia Questionnaire. End-of-period questionnaires:
only Z improved the Insomnia Severity Index more than P did.
Safety: all treatments were tolerated well.
Conclusion: LY2624803 improved subjective impression of sleep,
sleep quantity, and measures of sleep initiation and sleep maintenance in
outpatients with chronic insomnia.
0516
THE EFFECT OF ESZOPICLONE ON STAGE 2 SLEEP:
RESULTS FROM STUDIES IN ADULT AND ELDERLY
PATIENTS WITH PRIMARY INSOMNIA
Zammit G 1 , Grinnell T 2 , Marshall RD 2 , Zummo J 2 , Schweizer E 3
1
Clinilabs, New York, NY, USA, 2 CRMA, Sunovion Pharmceuticals
Inc., Marlborough, MA, USA, 3 Paladin Consulting Group, Hoboken,
NJ, USA
Introduction: It is understood that sleep architecture varies across the
life span. Sleep architecture changes are a pharmacological signature of
GABAergic hypnotic drugs. This analysis aimed to compare the effect
of eszopiclone on the polysomnographic (PSG) profile of adult and elderly
patients with primary insomnia.
Methods: For comparative purposes, absolute (mean minutes) and percent
of total sleep time (TST) in each stage of sleep were analyzed from
PSG data captured at Week 2 from 2 double-blind, placebo-controlled
studies of eszopiclone with different durations: a 6-week study in adult
patients aged18-64 (3 mg; n=204) and a 2-week study in elderly patients
aged 64-86 (2 mg; n=264).
Results: Relative to placebo, eszopiclone increased absolute time
(minutes) in stage 2 in both patient groups at the Week 2 time point
(Adults: Day 15: 22.5 minutes, p=0.002; Elderly: Day 14: 21.43 minutes,
p