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Dictionary of Evidence-based Medicine.pdf

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D<br />

DEADLE<br />

DEADLE stands for Declining Exponential Approximation <strong>of</strong> Discounted<br />

Life Expectancy. The model approximates life expectancy using an exponential<br />

model (see DEALE) and then discounts the estimated life<br />

expectancy (LE) to the present using the formula:<br />

LE = -^<br />

where ja is the mortality rate constant and i the effective discount rate. A<br />

value <strong>of</strong> 5% is common but values <strong>of</strong> 3-6% have been used (Martens L, van<br />

Doorslaer E (1990) Dealing with discounting. An application to the cost<br />

effectiveness <strong>of</strong> intracoronary thrombolysis with streptokinase. International<br />

Journal <strong>of</strong> Technical Assessment in Health Care. 6: 139^5).<br />

DEALE<br />

DEALE stands for Declining Exponential Approximation <strong>of</strong> Life Expectancy,<br />

a method developed for approximating life expectancy. The method<br />

describes survival probability P(t) as an exponential decay curve:<br />

P(t) = e*<br />

where [i = mortality rate constant and t the time. If t is in units <strong>of</strong> year (y)<br />

then jo, is in units <strong>of</strong> y" 1 . The life expectancy is then estimated by integrating<br />

the area under the survival probability time curve. This can be shown to be<br />

equal to the reciprocal <strong>of</strong> the mortality rate constant or for 1 . The expected<br />

number <strong>of</strong> remaining life-years can therefore be compared for groups with<br />

different mortality rates by estimating the mortality rate constants from<br />

the corresponding survival probability time curves (Beck JR, Kassirer JP,<br />

Paulker SG (1982) A convenient approximation <strong>of</strong> life expectancy: the<br />

'DEALE'. American Journal <strong>of</strong> <strong>Medicine</strong>. 73: 863-97).

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