Dictionary of Evidence-based Medicine.pdf
Dictionary of Evidence-based Medicine.pdf
Dictionary of Evidence-based Medicine.pdf
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D<br />
DEADLE<br />
DEADLE stands for Declining Exponential Approximation <strong>of</strong> Discounted<br />
Life Expectancy. The model approximates life expectancy using an exponential<br />
model (see DEALE) and then discounts the estimated life<br />
expectancy (LE) to the present using the formula:<br />
LE = -^<br />
where ja is the mortality rate constant and i the effective discount rate. A<br />
value <strong>of</strong> 5% is common but values <strong>of</strong> 3-6% have been used (Martens L, van<br />
Doorslaer E (1990) Dealing with discounting. An application to the cost<br />
effectiveness <strong>of</strong> intracoronary thrombolysis with streptokinase. International<br />
Journal <strong>of</strong> Technical Assessment in Health Care. 6: 139^5).<br />
DEALE<br />
DEALE stands for Declining Exponential Approximation <strong>of</strong> Life Expectancy,<br />
a method developed for approximating life expectancy. The method<br />
describes survival probability P(t) as an exponential decay curve:<br />
P(t) = e*<br />
where [i = mortality rate constant and t the time. If t is in units <strong>of</strong> year (y)<br />
then jo, is in units <strong>of</strong> y" 1 . The life expectancy is then estimated by integrating<br />
the area under the survival probability time curve. This can be shown to be<br />
equal to the reciprocal <strong>of</strong> the mortality rate constant or for 1 . The expected<br />
number <strong>of</strong> remaining life-years can therefore be compared for groups with<br />
different mortality rates by estimating the mortality rate constants from<br />
the corresponding survival probability time curves (Beck JR, Kassirer JP,<br />
Paulker SG (1982) A convenient approximation <strong>of</strong> life expectancy: the<br />
'DEALE'. American Journal <strong>of</strong> <strong>Medicine</strong>. 73: 863-97).