Dictionary of Evidence-based Medicine.pdf
Dictionary of Evidence-based Medicine.pdf
Dictionary of Evidence-based Medicine.pdf
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68 <strong>Dictionary</strong> <strong>of</strong> <strong>Evidence</strong>-<strong>based</strong> <strong>Medicine</strong><br />
Generalizability (see External validity)<br />
Generalizability theory<br />
Classic test theory assumes that an observed test score is made up <strong>of</strong> two<br />
components, a true score and an error term. The ratio <strong>of</strong> the true variance<br />
to the composite (true + error) variance is the reliability coefficient.<br />
Generalizability theory proposes that whenever measurements are taken,<br />
there are many sources <strong>of</strong> variance (referred to as facets) contributing error<br />
to the estimates being made. An important objective <strong>of</strong> any estimation<br />
is therefore the identification and measurement <strong>of</strong> those variance components<br />
through appropriate factorial studies. Such studies are referred to<br />
as generalizability or G studies in the literature relating to development <strong>of</strong><br />
measurement scales. Within the framework <strong>of</strong> generalizability theory,<br />
studies are also undertaken to evaluate how decision rules, such as pooling<br />
<strong>of</strong> different raters' scores, influence the reliability <strong>of</strong> the measurements.<br />
Such studies are called decision or D studies (Cronbach LJ, Gleser GC,<br />
Nanda H, Rajaramam N (1972) The dependability <strong>of</strong> behavioral measurement:<br />
theory <strong>of</strong> generalizability for scores. John Wiley, New York).<br />
Generalized linear model<br />
The generalized linear model is a statistical model for analysing the<br />
pattern <strong>of</strong> association and interactions between variables which takes the<br />
form:<br />
Where g(y] is a function <strong>of</strong> the dependent variable TJ, the beta values are the<br />
coefficients for the k predictor (x) variables. All generalized linear models<br />
include three components: (i) the random component which identifies the<br />
response variable; (ii) a systematic component which specifies the explanatory<br />
or predictor variables; (iii) a link which describes the functional<br />
relationship between the systematic component and the expected values <strong>of</strong><br />
the random component.<br />
Generalized linear models include ordinary regression analysis and analysis<br />
<strong>of</strong> variance as well as more complex models such as logistic regression<br />
models and log linear models.