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Brain–Computer Interfaces - Index of

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Non Invasive BCIs for Neuroprostheses Control <strong>of</strong> the Paralysed Hand 179<br />

An example <strong>of</strong> such a system is given in Fig. 4c. In this case, the TH was<br />

computed over a time period <strong>of</strong> 240 s by performing two “idle” runs without any<br />

imagination. The band power was then extracted (15–19 Hz band) and the mean (x)<br />

and standard deviation (sd) calculated. Here, TH was set to TH = x +3· sd. To<br />

give the user enough time to changing his mental state, a refractory phase <strong>of</strong> 5 s was<br />

implemented. In this time period, the classification output could not trigger another<br />

grasp phase. The first two pictures <strong>of</strong> Fig. 7 presents two shots during drinking.<br />

2.3.2 BCI-Training <strong>of</strong> Patient HK Using an Implanted Neuroprosthesis<br />

For practical reasons, training was performed over 3 days at the patient’s home.<br />

At first, the patient was asked to imagine different feet and left hand movements<br />

to determine which movements required the least concentration. After this prescreening,<br />

a cue-guided screening session was performed, where he was asked<br />

to imagine feet and left hand movements 160 times. Applying time-frequency<br />

analyses, the ERD/S maps were calculated. From these results, the most reactive frequency<br />

bands (14–16 and 18–22 Hz) were selected, and a classifier was set up. With<br />

this classifier, online feedback training was performed, which consisted <strong>of</strong> totally<br />

25 training runs using the Basket paradigm [11]. The task in this Basket experiment<br />

was to move a ball, falling with constant speed (falling duration was 3 s) from the<br />

top <strong>of</strong> the screen, towards the indicated target (basket) to the left or to the rigth at the<br />

bottom <strong>of</strong> the screen. Four runs (consisting <strong>of</strong> 40 trials each) with the best accuracy<br />

were then used to adapt the frequency bands (resulting in 12–14 Hz and 18–22 Hz)<br />

and calculate a new classifier (<strong>of</strong>fline accuracy was 71 %). This classifier was then<br />

used in an asynchronous paradigm for unguided training. Because <strong>of</strong> a significant<br />

ERD, left hand MI was used for switching. This decision was supported by the fact<br />

that, during the non-control state, foot activity was detected, so the classifier had a<br />

bias to the foot class. Therefore, the output <strong>of</strong> the classifier was compared with a<br />

threshold implemented in the class representing left hand movement imaginations<br />

(compare the brain switch scheme given in Fig. 2). Whenever the classifier output<br />

exceeded this threshold for a dwell time <strong>of</strong> 1 s, a switching signal was generated.<br />

Consecutively a refractory period <strong>of</strong> 3 s was implemented so that the movement<br />

control was stable and the probability <strong>of</strong> false positives was reduced. A 180-s run<br />

without any MI showed no switch-action. After the BCI-training paradigm, the classifier<br />

output <strong>of</strong> the BCI was coupled with the Freehand(R) system. In Fig. 5a the<br />

averaged LDA output during the evaluation experiment is presented. The predefined<br />

threshold in this case 0.7 was exceeded 1 s prior the real switching action<br />

(dwell time) at second 0. Fig. 5b shows the corresponding band power features [14].<br />

2.4 Interferences <strong>of</strong> Electrical Stimulation with the BCI<br />

A grasp neuroprosthesis produces short electrical impulses with up to 40 mA<br />

(= 40 V assuming 1 k� electrode-skin resistance) in a frequency range from 16<br />

to 35 Hz. These strong stimulation pulses lead to interference in the μV-amplitude

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