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Brain–Computer Interfaces - Index of

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218 D.M. Taylor and M.E. Stetner<br />

followed by a positive peak, and the amplitude <strong>of</strong> these peaks can vary with movement<br />

direction. Work by Merhing and colleagues suggest that intended targets can<br />

be estimated just as well from these LFP amplitudes as from the firing rates <strong>of</strong><br />

individual neurons in monkeys performing a center-out task [26].<br />

Information useful for BCI control has been extracted in many forms from intracortical<br />

microelectrodes (firing rates, spike synchronization, local field potentials,<br />

etc.). All forms can be recorded from the same intracortical electrodes, and, if<br />

you have the computational power, all can be analyzed and used simultaneously.<br />

Complex detailed information about our activities and behavior can be gleaned<br />

from the signals recorded on these tiny microelectrode arrays. Current studies with<br />

intracortical electrodes show much promise for both rapid target selection and generation<br />

<strong>of</strong> signals that can be used to control full arm and hand movements. Because<br />

intracortical electrodes are so small, many hundreds to even thousands <strong>of</strong> microelectrodes<br />

can potentially be implanted in the cortex at one time. We have only begun to<br />

scratch the surface <strong>of</strong> the complex information that will likely be decoded and used<br />

for BCI control from intracortical electrodes in the future.<br />

References<br />

1. E.E. Fetz, Operant conditioning <strong>of</strong> cortical unit activity. Science, 163(870), 955–958, (1969)<br />

2. E.E. Fetz, D.V. Finocchio, Operant conditioning <strong>of</strong> specific patterns <strong>of</strong> neural and muscular<br />

activity. Science, 174(7), 431–435, (1971)<br />

3. A.B. Schwartz, R.E. Kettner, A.P. Georgopoulos, Primate motor cortex and free arm movements<br />

to visual targets in three-dimensional space. I. Relations between single cell discharge<br />

and direction <strong>of</strong> movement. J Neurosci, 8(8), 2913–2927, (1988)<br />

4. A.P. Georgopoulos, R.E. Kettner, A.B. Schwartz, Primate motor cortex and free arm movements<br />

to visual targets in three-dimensional space II: coding the direction <strong>of</strong> movement by a<br />

neural population. J Neurosci, 8(8), 2928–2937, (1988)<br />

5. A.P. Georgopoulos, J.T. Massey, Cognitive spatial-motor processes. 2. Information transmitted<br />

by the direction <strong>of</strong> two-dimensional arm movements and by neuronal populations in<br />

primate motor cortex and area 5. Exp Brain Res, 69(2), 315–326, (1988)<br />

6. G. Santhanam, S.I. Ryu, et al., A high-performance brain-computer interface. Nature,<br />

442(7099):195–198, (2006)<br />

7. D.W. Moran, A.B. Schwartz, Motor cortical representation <strong>of</strong> speed and direction during<br />

reaching. J Neurophysiol, 82(5), 2676–2692, (1999).<br />

8. L. Paninski, M.R. Fellows, et al., Spatiotemporal tuning <strong>of</strong> motor cortical neurons for hand<br />

position and velocity. J Neurophysiol, 91(1), 515–532, (2004)<br />

9. R.E. Kettner, A.B. Schwartz, A.P. Georgopoulos, Primate motor cortex and free arm movements<br />

to visual targets in three-dimensional space. III. Positional gradients and population<br />

coding <strong>of</strong> movement direction from various movement origins. J Neurosci, 8(8), 2938–2947,<br />

(1988)<br />

10. R. Caminiti, P.B. Johnson, A. Urbano, Making arm movements within different parts <strong>of</strong> space:<br />

dynamic aspects in the primary motor cortex. J Neurosci, 10(7), 2039–2058, (1990)<br />

11. E.V. Evarts, Relation <strong>of</strong> pyramidal tract activity to force exerted during voluntary movement.<br />

J Neurophysiol, 31(1), 14–27, (1968)<br />

12. J. Ashe, Force and the motor cortex. Behav Brain Res, 86(1), 1–15, (1997)<br />

13. Q.G. Fu, D. Flament, et al., Temporal coding <strong>of</strong> movement kinematics in the discharge <strong>of</strong><br />

primate primary motor and premotor neurons. J Neurophysiol, 73(2), 2259–2263, (1995)

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