Research Report 2010 - MDC

Figure 3. Myoblast fusion in mice requires Rac1 and Cdc42. In themuscle of a control animal (A), single myoblasts (visualized by MyoDin red) fuse to generate multinucleated myotube. In conditional Rac1(B) or Cdc42 (C) mutant muscle, myoblasts do not fuse and myofibersremain short and thin.ControlRac1 fl/fl ;Lbx1 creCdc42 fl/fl ;Lbx1 creSelected publicationsVasyutina E, Martarelli B, Brakebusch C, Wende H, Birchmeier C (2009)The small g-proteins rac1 and cdc42 are essential for myoblast fusion inthe mouse. Proc Natl Acad Sci U S A 106: 8935-8940Storm R, Cholewa-Waclaw J, Reuter K, Brohl D, Sieber M, Treier M, Muller T,Birchmeier C (2009) The bhlh transcription factor olig3 marks the dorsalneuroepithelium of the hindbrain and is essential for the development ofbrainstem nuclei. Development 136: 295-305Wildner H, Gierl MS, Strehle M, Pla P, Birchmeier C (2008) Insm1 (ia-1)is a crucial component of the transcriptional network that controlsdifferentiation of the sympatho-adrenal lineage. Development 135:473-481Hori K, Cholewa-Waclaw J, Nakada Y, Glasgow SM, Masui T, Henke RM,Wildner H, Martarelli B, Beres TM, Epstein JA, Magnuson MA, MacdonaldRJ, Birchmeier C, Johnson JE (2008) A nonclassical bhlh rbpj transcriptionfactor complex is required for specification of gabaergic neuronsindependent of notch signaling. Genes Dev 22: 166-178Gierl MS, Karoulias N, Wende H, Strehle M, Birchmeier C (2006) The zincfingerfactor insm1 (ia-1) is essential for the development of pancreaticbeta cells and intestinal endocrine cells. Genes Dev 20: 2465-2478Function and Dysfunction of the Nervous System 153