Research Report 2010 - MDC

ing constructs, which express small interference RNAssuited to downregulate specific genes. The first targetgene was the insulin receptor yielding a uniqueinducible rat model for diabetes mellitus type 2.Selected PublicationsAlenina, N., Kikic, D., Todiras, M., Mosienko, V., Qadri, F., Plehm, R., Boye, P.,Vilianovich, L., Sohr, R., Tenner, K., Hörtnagl, H., Bader, M. (2009) Growthretardation and altered autonomic control in mice lacking brainserotonin. Proc. Natl. Acad. Sci. USA. 106, 10332-10337.Kotnik, K., Popova, E., Todiras, M., Mori, M.A., Alenina, N., Seibler, J., Bader, M.(2009) Inducible transgenic rat model for diabetes mellitus based onshRNA-mediated gene knockdown. PLoS ONE. 4, e5124Schulze-Topphoff, U., Prat, A., Prozorovski, T., Siffrin, V., Paterka, M., Herz, J.,Bendix, I., Ifergan, I., Schadock, I., Mori, M.A., van Horssen, J., Schröter, F.,Han, M.H., Bader, M., Steinman, L., Zipp, F. (2009) Activation of kininreceptor B1 limits encephalitogenic T lymphocyte recruitment to the CNS.Nat. Med., 15, 788-793.Shmidt, T., Hampich, F., Ridders, M., Schultrich, S., Hans, V.H., Tenner, K.,Vilianovich, L., Qadri, F., Alenina, N., Hartmann, E., Köhler, M., Bader, M.(2007) Normal brain development in importin alpha 5 deficient mice.Nat. Cell. Biol. 9, 1337-1338.Langenickel, TH, Buttgereit, J, Pagel-Langenickel, I, Lindner, M, Monti, J,Beuerlein, K, Al-Saadi, N, Plehm, R, Popova, E, Tank, J, Dietz, R, Willenbrock,R, Bader, M. (2006). Cardiac hypertrophy in transgenic rats expressing adominant-negative mutant of the natriuretic peptide receptor B. Proc.Natl. Acad. Sci. USA 103, 4735-4740.Cardiovascular and Metabolic Disease Research 51