Research Report 2010 - MDC

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Extramural funding in 2008 (in thousands of €) / Drittmittelfinanzierung 2008 in T €Extramural funds / DrittmittelgeberAmounts / DrittmittelerlöseGerman Research Foundation/Deutsche Forschungsgemeinschaft 6.138EU/EU 2.266Industry and other organizations/Industrie und sonstige Organisationen 4.295Federal Ministry of Education and Research/Bundesministerium für Bildung und Forschung (BMBF) 8.665State of Berlin/Land Berlin 181Total / Gesamt 21.545State of Berlin/Land Berlin1%EU/EU11%Industry and other organizations/Industrie und sonstige Organisationen20%40%Federal Ministry of Education and Research/Bundesministerium für Bildung und Forschung (BMBF)German Research Foundation/Deutsche Forschungsgemeinschaft28%268 Overview
Research Projects 2008-2009Forschungsprojekte 2008-2009Collaborative research centres (SFB) und transregional research centres (TRR) ofthe German Research Foundation (DFG)SFB 449:Structure and function of membrane receptorsSFB 594:Molecular machines in protein folding and protein transportSFB 633:SFB 650:SFB 577:SFB 618:SFB 665:SFB 740:SFB 555:SFB Transregio 19:SFB Transregio 36:SFB Transregio 43:SFB Transregio 54:Induction and modulation of T cell-impartedImmunreactions in the gastrointestinal tractCellular approaches to the suppression of undesirableimmunroactionsMolecular principles of the clinical variability of monogenicdiseasesTheoretic biology: robustness, modularity and evolutionarydesign of living systemsDevelopment disorders in the nervous systemFrom molecules to modules: Organization and dynamics offunctional units in cellsComplex non-linear processesInflammatory cardiomyopathy – molecular pathogenesisand therapyPrinciples and applications of adoptive T cell therapyThe brain as a target of inflammatory processesGrowth and survival, plasticity und cellular interactivity oflymphatic neoplasiasSFB Transregio 52: Transcriptional programming of individual T-cell populationsSFB Transregio 3: Mesial temporal lobe epilepsiesSFB Transregio 3: Mesiale Temporallappen-EpilepsienSonderforschungsbereiche (SFB) und Transregios (TRR) der DeutschenForschungsgemeinschaft (DFG)SFB 449Struktur und Funktion membranständiger RezeptorenSFB 594SFB 633SFB 650SFB 577SFB 618SFB 665SFB 740SFB 555SFB Transregio 19SFB Transregio 36SFB Transregio 43SFB Transregio 54SFB Transregio 52SFB Transregio 3Molekulare Maschinen in Proteinfaltung undProteintransportInduktion und Modulation T-zellvermittelter Immunreaktionenim GastrointestinaltraktZelluläre Ansätze zur Suppression unerwünschterImmunreaktionenMolekulare Grundlagen klinischer Variabilität monogenbedingter KrankheitenTheor. Biologie: Robustheit, Modularität und evolutionäresDesign lebender SystemeEntwicklungsstörungen im NervensystemVon Molekülen zu Modulen: Organisation und Dynamikzellulärer FunktionseinheitenKomplexe nichtlineare ProzesseInflammatorische Kardiomyopathie – MolekularePathogenese und TherapieGrundlagen und Anwendung adoptiver T-ZelltherapieDas Gehirn als Angriffsziel inflammatorischer ProzesseWachstum und Überleben, Plastizität und zelluläreInteraktivität lymphatischer NeoplasienTranskriptionelle Programmierung individueller T-Zell-PopulationenMesiale Temporallappen-EpilepsienNational Genome Research Network (NGFN-2) ProjectsGenome network cardiovascular diseases: Comparative genomics of leftventricular hypertrophy and dysfunction in hypertensionGenome network cardiovascular diseases: Functional genomics of cardiacdamage in hypertensionGenome network cardiovascular diseases: Location Berlin MDC: Prevalenceof Titin-mutations and identification of new disease genes in patients withfamilial dilative cardiomyopathySystematic-methodical platform "DNA", location MDC, Berlin"Systematic-methodical platform "DNA": National genotyping platformSystematic-methodical platform GEM: Location Berlin "Genomwide correlationanalysis and association studies with 10K and 100K arrays"Genome network neuro: Systematic gene identification und functional analysisfor frequent neurologic diseasesGenome network neuro: Molecular genetic identification of activity scheduledgene configurations of genetically determined epilepsiesCancerNet: Organ Specificity of Colorectal Cancer MetastasisSystematic-methodical platform "Protein": Verification and identification ofprotein-protein interactions and systematic analysis of target proteins via X-ray structure analysis, TP 7 – Structure determinationSystematic-methodical platform "Protein": Verification and identification ofprotein-protein interactions and systematic analysis of target proteins via X-ray structure analysis, TP 20 – Project managementSystematic-methodical platform "Protein": Verification and identification ofprotein-protein interactions and systematic analysis of target proteins via X-ray structure analysis, TP 8 Yeast two-hybrid protein interaction networksSystematic-methodical platform "Protein", Location MDC Berlin: Verificationand identification of protein-protein interactions and systematic analysis oftarget proteins via X-ray structure analysis, TP 1.1. Subcloning of full-lengthORF's and cDNA-fragments into expression plasmidsDetermination of genes underlying Williams-Beuren Syndrom by generationof an allelic series of mutations with the aid of novel transposonapproaches, TP1Projekte im Nationalen Genomforschungsnetz (NGFN-2)Genomforschungsnetz Kardiovaskuläre Krankheiten: Vergleichende Genomicsder links-ventrikulären Hypertrophie and Dysfunktion bei BluthochdruckGenomforschungsnetz Kardiovaskuläre Krankheiten: Funktionelle Genomicsder Herzschädigung bei BluthochdruckGenomforschungsnetz Kardiovaskuläre Krankheiten: Standort Berlin MDC:Prävalenz von Titin-Mutationen und Identifizierung neuer Krankheitsgene inPatienten mit Familiärer Dilativer KardiomyopathieSystematisch-Methodische Plattform "DNA", Standort MDC, Berlin"Systematisch-Methodische Plattform "DNA": NationaleGenotypisierungsplattformSystematisch-methodische Plattform GEM: Standort Berlin "GenomweiteKopplungsanalyse und Assoziationsstudien mit den 10K und 100K Chips"Genomnetz Neuro: Systematische Genidentifikation und funktionelle Analysenbei häufigen neurologischen ErkrankungenGenomnetz Neuro: Molekulargenetische Identifizierung von disponierendenGenkonfigurationen bei genetisch determinierten EpilepsienCanerNet: Organspezifität von Darmkrebs MetastasierungSystematisch-Methodische Plattform "Protein": Vertifikation und Identifikationvon Protein-Protein Interaktionen und systematische Analyse vonTargetproteinen mittels Röntgenstrukturanalyse, TP 7 – Struktur- aufklärungSystematisch-Methodische Plattform "Protein": Vertifikation und Identifikationvon Protein-Protein Interaktionen und systematische Analyse vonTargetproteinen mittels Röntgenstrukturanalyse, TP 20 – Projekt- managementSystematisch-Methodische Plattform "Protein": Vertifikation und Identifikationvon Protein-Protein Interaktionen und systematische Analyse vonTargetproteinen mittels Röntgenstrukturanalyse, TP 8 Yeast two-hybrid ProteinInteraktionsnetzwerkSystematisch-Methodische Plattform "Protein", Standort MDC Berlin:Verifikation und Identifikation und systematische Analyse von Targetproteinenmittels Röntgenstrukturanalyse", TP 1.1. Umklonierung von full-length ORF'sund cDNA-Fragmenten in Expressions-PlasmideBestimmung der Gene, die dem Williams-Beuren Syndrom zugrundeliegendurch die Generation einer allelischen Serie von Mutationen mit Hilfe von neuartigenTransposon Ansätzen, TP1Overview 269
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Research Report 2010MAX DELBRÜCK C
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ContentInhaltContentInhalt.........
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Surgical OncologyPeter M. Schlag...
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at the MDC. The role of the institu
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in discovering genes that contribut
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The ECRC offers research space and
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etween disciplines such as biology,
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approaches from bioinformatics/syst
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von Humboldt Foundation (AvH). The
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organization to a larger, multi-fac
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Cardiovascular and Metabolic Diseas
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electrical signals. More recent wor
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Basic Cardiovascular FunctionStruct
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Figure 2: SORLA and sortilin in neu
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Annette Hammes(Delbrück Fellow)Str
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Ingo L. MoranoStructure of the Grou
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Figure 3. Membrane resealing assay
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Michael GotthardtStructure of the G
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Structure of the GroupSalim Seyfrie
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Structure of the GroupFerdinand le
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Francesca M. SpagnoliStructure of t
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Structure of the GroupKai M. Schmid
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Genetics and Pathophysiology of Car
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Figure 2. Planariato experimentally
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Norbert HübnerStructure of the Gro
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Structure of the GroupGroup LeaderF
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Figure 2. Omega-3 fatty acids prote
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Structure of the GroupDominik N. M
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Rainer DietzStructure of the GroupG
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Figure 2. Cardiac-restricted ablati
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Ludwig ThierfelderStructure of the
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standing of the molecular and cellu
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Structure of the GroupThoralf Niend
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Michael BaderStructure of the Group
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Natriuretic peptide systemJens Butt
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Structure of the GroupZsuzsanna Izs
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Young-Ae LeeStructure of the GroupG
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Structure of the GroupMatthias Selb
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Matthew PoyStructure of the GroupGr
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Jana WolfStructure of the GroupGrou
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Structure of the GroupGroup LeaderD
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Cancer Research ProgramKrebsforschu
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are responsible for the emergence o
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tral component of the canonical Wnt
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lead to an aberrant constitutive ac
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How Notch- and TGFβ signaling casc
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tures of the chronic phase in human
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oped a new safeguard that is based
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Graduate StudentsSeda Cöl ArslanCa
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investigation, as is the cause of c
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Graduate StudentsÖzlem Akilli Özt
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onment, the (cancer) stem cell nich
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The pluripotent state of murine and
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In the morula of the early mouse em
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Graduate StudentsRami Hamscho*Qingb
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esis and granulopoiesis. We showed
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URE ∆/∆ mice regularly develope
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PD Dr. Wolfgang Walther (GroupLeade
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For the delivery of naked DNA into
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ACBDMyc and FoxO transcription fact
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Graduate StudentsKatrin BagolaHolge
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Heinemann, we could also identify t
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Above: Tip of chromosom3L showing t
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Graduate StudentsSarbani Bhattachar
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vesicle transport to the Golgi. Our
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acbFigure 1a: EHD2 is tubulatingpho
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KnowledgeProbabilitiesknownPossible
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Graduate and undergraduatestudentsU
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successive oncogenic mutations. We
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CXCR5 drives the development of ect
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Graduate and undergraduatestudentsW
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Graduate andUndergraduate StudentsM
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Angela MensenStefanie WittstockBjö
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deficient mice, both major effector
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ant of CD3 delta coding for a 45-me
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Robert KudernatschLi-Min LiuAna Mil
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Sebastian GüntherTechnical Assista
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Graduate StudentsJana RolffAnnika W
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with murine hepatocytes showed morp
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Function and Dysfunction of the Ner
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The Neuroscience Department also es
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the coming years, Björn Schröder
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mice. Further analysis of the funct
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Signaling Pathways and Mechanisms i
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Control Olig3 -/-ABFigure 2. Geneti
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Thomas J. JentschStructure of the G
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Figure 2. Cellular model for ionic
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Structure of the GroupGroup LeaderF
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paired-pulse facilitation, less dep
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Gary R. LewinStructure of the Group
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Model summarizing the three waves o
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Structure of the GroupInes Ibañez-
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Jochen C. MeierStructure of the Gro
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Björn Christian SchroederStructure
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Structure of the GroupJan Siemens(S
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Structure of the GroupGroup LeaderD
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Imaging of the Living BrainStructur
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Pathophysiological Mechanisms of Ne
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Figure 2. Iba1 positive microglia c
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Erich E. WankerStructure of the Gro
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Scientific-Technical StaffAnja Frit
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Structure of the GroupJan Bieschke(
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Berlin Institute of Medical Systems
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etes, metabolic diseases and neurod
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A number of MDC investigators have
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Technical AssistantsClaudia Langnic
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has become a standardized data flow
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Phylogeny of cellulase genes from P
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Experimental and Clinical Research
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his patients, and a basic research
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The ultrahigh field MR facility was
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Structure of the GroupSimone Spuler
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Ralph KettritzStructure of the Grou
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Structure of the GroupJeanette Schu
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Maik GollaschStructure of the Group
Page 243 and 244: Technology PlatformsComputational B
Page 245 and 246: projects/ard/] to detect repeats li
Page 247 and 248: Simulation of line-scan images of C
Page 249 and 250: Development of an MRM method for qu
Page 251 and 252: mobility or turnover of the underly
Page 253 and 254: Left: Inside view of a FACSAria2 (f
Page 255 and 256: Examples fort the use of EM methods
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Page 260 and 261: Academic Appointments 2008-2009Beru
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Page 264 and 265: “Bioinformatics in Quantitative B
Page 266 and 267: Delbrück FellowsDelbrück-Stipendi
Page 268 and 269: Yinth Andrea Bernal-Sierra, a PhD s
Page 270 and 271: Congresses and Scientific MeetingsK
Page 272 and 273: SeminarsSeminare2008Speaker Institu
Page 274 and 275: Speaker Institute TitleKiyoshi Mori
Page 276 and 277: 2009Speaker Institute TitleDavid G.
Page 278 and 279: Speaker Institute TitleJuri Rappsil
Page 280 and 281: The Helmholtz AssociationDie Helmho
Page 282 and 283: The Berlin-Buch CampusDer Campus Be
Page 284: the MDC, the existing collaboration
Page 287 and 288: Prof. Dr. Gary R. LewinMDC Berlin-B
Page 289 and 290: Prof. Dr. Renato ParoCenter of Bios
Page 291 and 292: Staff CouncilThe Staff Council is i
Page 293: Type of Financing/Art der Finanzier
Page 297 and 298: CIC-5 Regulation und Endocytose am
Page 299 and 300: MDCMAX-DELBRÜCK-CENTRUMFÜR MOLEKU
Page 301 and 302: Index 275Bröske, A. . . . . . . .
Page 303 and 304: Index 277Gross, V. . . . . . . . .
Page 305 and 306: Index 279Kur, E. . . . . . . . . .
Page 307 and 308: Index 281Piano, F. . . . . . . . .
Page 309 and 310: Index 283Smink, J. . . . . . . . .
Page 312 and 313: Campus MapCampusplanRobert-Rössle-
Page 314: How to find your way to the MDCDer
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Research Report 2010 - MDC

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