Research Report 2010 - MDC

Kardiovaskuläre Forschung, DZHK) and a GermanInstitute for Cardiovascular Research (DeutschesInstitut für Kardiovaskuläre Forschung, DIHK) whichhave been proposed by the MDC and Charité. The proposalforesees the construction of the DIHK on theBerlin-Buch campus, which would put it in the immediatevicinity of the ECRC and its technological platformsand infrastructure.Structure of the ECRCDirectorFriedrich C. LuftChief AdministratorRegina JüngerProgram ManagerCornelia MaurerSteering committeeWalter Rosenthal (MDC Director)Annette Grüters-Kieslich (Charité Dean)Cornelia Lanz (MDC Administrative Director)Gerrit Fleige (Administrative Head of the CharitéFaculty)ECRC Council (chairman)Thomas SommerSelected publications of ECRC participantsMathas, S, Kreher, S, Meaburn, KJ, Jöhrens, K, Lamprecht, B, Assaf, C,Sterry, W, Kadin, ME, Daibata, M, Joos, S, Hummel, M, Stein, H, Janz, M,Anagnostopoulos, I, Schrock, E, Misteli, T, Dörken, B. (2009) Gene deregulationand spatial genome reorganization near breakpoints prior toformation of translocations in anaplastic large cell lymphoma. ProcNatl Acad Sci U S A. 106, 5831-6.Stein, U, Walther, W, Arlt, F, Schwabe, H, Smith, J, Fichtner, I, Birchmeier,W, Schlag, PM. (2009) MACC1, a newly identified key regulator of HGF-MET signaling, predicts colon cancer metastasis. Nat Med. 15, 59-67.Prozorovski, T, Schulze-Topphoff, U, Glumm, R, Baumgart, J, Schröter, F,Ninnemann, O, Siegert, E, Bendix, I, Brüstle, O, Nitsch, R, Zipp, F, Aktas, O.(2008) Sirt1 contributes critically to the redox-dependent fate of neuralprogenitors. Nat Cell Biol. 10, 385-94.Hauck, L, Harms, C, An, J, Rohne, J, Gertz, K, Dietz, R, Endres, M, vonHarsdorf, R. (2008) Protein kinase CK2 links extracellular growth factorsignaling with the control of p27(Kip1) stability in the heart. Nat Med.14, 315-24.Organisationsstruktur des ECRCDirektorFriedrich C. LuftKaufmännische LeiterinRegina JüngerProgramm-ManagerinCornelia MaurerLenkungsausschussWalter Rosenthal (Wissenschaftlicher Vorstand, MDC)Annette Grüters-Kieslich (Dekanin, Charité)Cornelia Lanz (Administrativer Vorstand, MDC)Gerrit Fleige (Kaufmännischer Leiter der Fakultät,Charité)ECRC-Rat (Vorsitzender)Thomas SommerAusgewählte Publikationen von Forschern des ECRCMathas, S, Kreher, S, Meaburn, KJ, Jöhrens, K, Lamprecht, B, Assaf, C,Sterry, W, Kadin, ME, Daibata, M, Joos, S, Hummel, M, Stein, H, Janz, M,Anagnostopoulos, I, Schrock, E, Misteli, T, Dörken, B. (2009) Gene deregulationand spatial genome reorganization near breakpoints prior to formationof translocations in anaplastic large cell lymphoma. Proc NatlAcad Sci U S A. 106, 5831-6.Stein, U, Walther, W, Arlt, F, Schwabe, H, Smith, J, Fichtner, I, Birchmeier, W,Schlag, PM. (2009) MACC1, a newly identified key regulator of HGF-METsignaling, predicts colon cancer metastasis. Nat Med. 15, 59-67.Prozorovski, T, Schulze-Topphoff, U, Glumm, R, Baumgart, J, Schröter, F,Ninnemann, O, Siegert, E, Bendix, I, Brüstle, O, Nitsch, R, Zipp, F, Aktas, O.(2008) Sirt1 contributes critically to the redox-dependent fate of neuralprogenitors. Nat Cell Biol. 10, 385-94.Hauck, L, Harms, C, An, J, Rohne, J, Gertz, K, Dietz, R, Endres, M, vonHarsdorf, R. (2008) Protein kinase CK2 links extracellular growth factorsignaling with the control of p27(Kip1) stability in the heart. Nat Med.14, 315-24.Machnik, A, Neuhofer, W, Jantsch, J, Dahlmann, A, Tammela, T, Machura,K, Park, JK, Beck, FX, Müller, DN, Derer, W, Goss, J, Ziomber, A, Dietsch, P,Wagner, H, van Rooijen, N, Kurtz, A, Hilgers, KF, Alitalo, K, Eckardt, KU,Luft, FC, Kerjaschki, D, Titze, J. (2009) Macrophages regulate salt-dependentvolume and blood pressure by a vascular endothelial growth factor-C-dependent buffering mechanism. Nat Med. 15, 545-52.Machnik, A, Neuhofer, W, Jantsch, J, Dahlmann, A, Tammela, T, Machura,K, Park, JK, Beck, FX, Müller, DN, Derer, W, Goss, J, Ziomber, A, Dietsch, P,Wagner, H, van Rooijen, N, Kurtz, A, Hilgers, KF, Alitalo, K, Eckardt, KU,Luft, FC, Kerjaschki, D, Titze, J. (2009) Macrophages regulate saltdependentvolume and blood pressure by a vascular endothelialgrowth factor-C-dependent buffering mechanism. Nat Med. 15, 545-52.The Experimental and Clinical Research Center 207