Research Report 2010 - MDC

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Organisation chart of the Max-Delbrück-Center for Molecular Medicine Foundation under public lawScientific CommitteeChairProf. Dr. Reinhard JahnScientific CouncilChairProf. Dr. Gary LewinBoard of TrusteesChairMinDir Dr. Peter LangeBoard of DirectorsScientific DirectorProf. Dr. Walter RosenthalAdministrative DirectorCornelia LanzM O L E C U L A R M E D I C I N ECardiovascular and Metabolic Diseases Coordinator: Prof. Dr. Thomas WillnowClinical ResearchCoordinator Prof. Dr. Friedrich C. LuftBasic conceptsof cardiovascular functionProf. Dr. Thomas WillnowProf. Dr. Ingo L. MoranoProf. Dr. Michael GotthardtProf. Dr. Thomas JentschDr. Francesca SpagnoliDr. Ferdinand le NobleDr. Salim SeyfriedDr. Kai Schmidt-OttGenetics and pathophysiology ofcardiovascular diseasesProf. Dr. Nikolaus RajewskyProf. Dr. Norbert HübnerProf. Dr. Friedrich C. LuftProf. Dr. Ludwig ThierfelderDr. Markus LandthalerDr. Matthew PoyProf. Dr. Thoralf NiendorfCancer Research Coordinator: Prof. Dr. Claus ScheidereitClinical ResearchCoordinator: Prof. Dr. Peter SchlagSignaling pathways, cell biologyand tumor biologyProf. Dr. Achim LeutzProf. Dr. Claus ScheidereitProf. Dr. Clemens SchmittProf. Dr. Harald SaumweberProf. Dr. Peter M. SchlagProf. Dr. Walter BirchmeierProf. Dr. Peter DanielProf. Dr. Thomas SommerDr. Ulrike ZieboldDr. Frank RosenbauerStructural and functional genomicsProf. Dr. Udo HeinemannDr. Oliver DaumkeBioethicsDr. Christof TannertFunction and Dysfunction of the Nervous SystemCoordinators: Prof. Dr. Carmen Birchmeier-Kohler and Prof. Dr. Helmut KettenmannClinical ResearchCoordinator: Prof. Dr. Frauke ZippSignaling pathways and mechanismsin the nervous systemProf. Dr. Carmen BirchmeierProf. Dr. Jochen MeierProf. Dr. Gary LewinProf. Dr. Fritz G. RathjenDr. Inés Ibañez-TallonDr. Björn SchröderDr. Jan Erik SiemensDr. James PouletImaging the living brainProf. Dr. Frauke Zipp272 Overview
MDCMAX-DELBRÜCK-CENTRUMFÜR MOLEKULARE MEDIZINBERLIN-BUCHStaff CouncilChairIngo KahlRepresentativesWoman’s Representative: Dr. Hannelore HaaseData protection officer: Christine Rieffel-BrauneAnti-Corruption Officer: Ina HerrmannOmbudsman: Prof. Dr. Jens ReichStaff OfficesAdministrationand InfrastructureScientific CoordinationDr. Christina QuenselPersonnel DepartmentDr. Hans-J. SeehrichProf. Dr. Rainer DietzProf. Dr. Michael BaderProf. Dr. Young-Ae LeeDr. Matthias SelbachDr. Zsuzsanna IzsvákDr. Jana WolfAdministrative CoordinationDana LafuentePress / Public RelationsBarbara BachtlerFinances / ControllingAndrea WinnefeldAnimal FacilitiesDr. Karin JacobiTumor immunologyPD Dr. Martin LippProf. Dr. Thomas BlankensteinProf. Dr. Bernd DörkenProf. Dr. Antonio PezzuttoProf. Dr. Wolfgang UckertDr. Iduna FichtnerScience WritingRussel HodgeCongress OrganizationMichaela LangerInternational AffairsPamela CohenLibraryDr. Dorothea BusjahnITBernd LemkeTechnical Facility ManagementConstruction: Ralf StreckwallOperation: Michael ArnoldEU / Third Party FundsDr. Sabine BaarsPurchasing and Central ServicesWolfgang GrollPathophysiological mechanisms ofneurological and psychiatric diseasesProf. Dr. Helmut KettenmannProf. Dr. Erich WankerPhD CoordinationDr. Oksana SeumenichtSafetyDr. Regina DietlAuditing and Legal Affairs /Technology TransferChristine Rieffel-BrauneStand: November 2007Overview 273
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Research Report 2010MAX DELBRÜCK C
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ContentInhaltContentInhalt.........
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Surgical OncologyPeter M. Schlag...
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at the MDC. The role of the institu
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in discovering genes that contribut
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The ECRC offers research space and
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etween disciplines such as biology,
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approaches from bioinformatics/syst
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von Humboldt Foundation (AvH). The
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organization to a larger, multi-fac
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Cardiovascular and Metabolic Diseas
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electrical signals. More recent wor
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Basic Cardiovascular FunctionStruct
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Figure 2: SORLA and sortilin in neu
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Annette Hammes(Delbrück Fellow)Str
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Ingo L. MoranoStructure of the Grou
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Figure 3. Membrane resealing assay
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Michael GotthardtStructure of the G
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Structure of the GroupSalim Seyfrie
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Structure of the GroupFerdinand le
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Francesca M. SpagnoliStructure of t
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Structure of the GroupKai M. Schmid
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Genetics and Pathophysiology of Car
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Figure 2. Planariato experimentally
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Norbert HübnerStructure of the Gro
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Structure of the GroupGroup LeaderF
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Figure 2. Omega-3 fatty acids prote
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Structure of the GroupDominik N. M
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Rainer DietzStructure of the GroupG
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Figure 2. Cardiac-restricted ablati
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Ludwig ThierfelderStructure of the
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standing of the molecular and cellu
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Structure of the GroupThoralf Niend
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Michael BaderStructure of the Group
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Natriuretic peptide systemJens Butt
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Structure of the GroupZsuzsanna Izs
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Young-Ae LeeStructure of the GroupG
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Structure of the GroupMatthias Selb
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Matthew PoyStructure of the GroupGr
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Jana WolfStructure of the GroupGrou
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Structure of the GroupGroup LeaderD
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Cancer Research ProgramKrebsforschu
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are responsible for the emergence o
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tral component of the canonical Wnt
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lead to an aberrant constitutive ac
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How Notch- and TGFβ signaling casc
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tures of the chronic phase in human
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oped a new safeguard that is based
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Graduate StudentsSeda Cöl ArslanCa
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investigation, as is the cause of c
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Graduate StudentsÖzlem Akilli Özt
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onment, the (cancer) stem cell nich
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The pluripotent state of murine and
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In the morula of the early mouse em
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Graduate StudentsRami Hamscho*Qingb
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esis and granulopoiesis. We showed
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URE ∆/∆ mice regularly develope
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PD Dr. Wolfgang Walther (GroupLeade
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For the delivery of naked DNA into
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ACBDMyc and FoxO transcription fact
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Graduate StudentsKatrin BagolaHolge
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Heinemann, we could also identify t
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Above: Tip of chromosom3L showing t
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Graduate StudentsSarbani Bhattachar
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vesicle transport to the Golgi. Our
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acbFigure 1a: EHD2 is tubulatingpho
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KnowledgeProbabilitiesknownPossible
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Graduate and undergraduatestudentsU
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successive oncogenic mutations. We
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CXCR5 drives the development of ect
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Graduate and undergraduatestudentsW
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Graduate andUndergraduate StudentsM
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Angela MensenStefanie WittstockBjö
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deficient mice, both major effector
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ant of CD3 delta coding for a 45-me
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Robert KudernatschLi-Min LiuAna Mil
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Sebastian GüntherTechnical Assista
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Graduate StudentsJana RolffAnnika W
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with murine hepatocytes showed morp
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Function and Dysfunction of the Ner
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The Neuroscience Department also es
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the coming years, Björn Schröder
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mice. Further analysis of the funct
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Signaling Pathways and Mechanisms i
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Control Olig3 -/-ABFigure 2. Geneti
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Thomas J. JentschStructure of the G
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Figure 2. Cellular model for ionic
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Structure of the GroupGroup LeaderF
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paired-pulse facilitation, less dep
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Gary R. LewinStructure of the Group
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Model summarizing the three waves o
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Structure of the GroupInes Ibañez-
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Jochen C. MeierStructure of the Gro
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Björn Christian SchroederStructure
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Structure of the GroupJan Siemens(S
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Structure of the GroupGroup LeaderD
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Imaging of the Living BrainStructur
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Pathophysiological Mechanisms of Ne
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Figure 2. Iba1 positive microglia c
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Erich E. WankerStructure of the Gro
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Scientific-Technical StaffAnja Frit
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Structure of the GroupJan Bieschke(
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Berlin Institute of Medical Systems
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etes, metabolic diseases and neurod
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A number of MDC investigators have
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Technical AssistantsClaudia Langnic
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has become a standardized data flow
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Phylogeny of cellulase genes from P
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Experimental and Clinical Research
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his patients, and a basic research
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The ultrahigh field MR facility was
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Structure of the GroupSimone Spuler
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Ralph KettritzStructure of the Grou
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Structure of the GroupJeanette Schu
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Maik GollaschStructure of the Group
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Technology PlatformsComputational B
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projects/ard/] to detect repeats li
Page 247 and 248: Simulation of line-scan images of C
Page 249 and 250: Development of an MRM method for qu
Page 251 and 252: mobility or turnover of the underly
Page 253 and 254: Left: Inside view of a FACSAria2 (f
Page 255 and 256: Examples fort the use of EM methods
Page 257: Oviducts lined up in pre-implantati
Page 260 and 261: Academic Appointments 2008-2009Beru
Page 262 and 263: Buch which is part of the Excellenc
Page 264 and 265: “Bioinformatics in Quantitative B
Page 266 and 267: Delbrück FellowsDelbrück-Stipendi
Page 268 and 269: Yinth Andrea Bernal-Sierra, a PhD s
Page 270 and 271: Congresses and Scientific MeetingsK
Page 272 and 273: SeminarsSeminare2008Speaker Institu
Page 274 and 275: Speaker Institute TitleKiyoshi Mori
Page 276 and 277: 2009Speaker Institute TitleDavid G.
Page 278 and 279: Speaker Institute TitleJuri Rappsil
Page 280 and 281: The Helmholtz AssociationDie Helmho
Page 282 and 283: The Berlin-Buch CampusDer Campus Be
Page 284: the MDC, the existing collaboration
Page 287 and 288: Prof. Dr. Gary R. LewinMDC Berlin-B
Page 289 and 290: Prof. Dr. Renato ParoCenter of Bios
Page 291 and 292: Staff CouncilThe Staff Council is i
Page 293 and 294: Type of Financing/Art der Finanzier
Page 295 and 296: Research Projects 2008-2009Forschun
Page 297: CIC-5 Regulation und Endocytose am
Page 301 and 302: Index 275Bröske, A. . . . . . . .
Page 303 and 304: Index 277Gross, V. . . . . . . . .
Page 305 and 306: Index 279Kur, E. . . . . . . . . .
Page 307 and 308: Index 281Piano, F. . . . . . . . .
Page 309 and 310: Index 283Smink, J. . . . . . . . .
Page 312 and 313: Campus MapCampusplanRobert-Rössle-
Page 314: How to find your way to the MDCDer
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Research Report 2010 - MDC

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