Research Report 2010 - MDC

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Structure of the GroupJeanette Schulz-MengerGroup LeaderProf. Dr. Jeanette Schulz-MengerScientistsDr. Steffen BohlDr. Philipp BoyeDipl.-ing Matthias DieringerDr. Florian v. Knobelsdorff-BrenkenhoffCardiovascular MagneticResonanceThe CMR group at the Franz-Volhard-Klinik has focused its research on the in vivoassessment of functional and structural myocardial abnormalities related toinflammatory diseases and coronary heart disease. We perform clinical research using a1.5 clinical MRI-scanner with dedicated cardiac software. We developed new approaches forthe differentiation of tissue changes in myocardial diseases. The application as researchtools and the translation into a clinical setting are the main interests of the group. Thesuccessful work led to the introduction of the University Professorship in Cardiology forNoninvasive Imaging focused on Cardiovascular magnetic resonance (CMR).In 2009 the Ultra-High-Field Facility was opened giving us the possibility to extend ourresearch field by developing translational research tools applying advanced imagingmodalities.Myocardial InjuryThe diagnosis of myocardial inflammation in differentdiseases and the assessment of myocardial tissuechanges during follow-up is a challenging task in cardiovascularresearch and clinical cardiology. Clinicalpresentation of patients with myocarditis or myocardialinvolvement in systemic disorders often mimicsother disorders and may vary from flu-like symptomsor subclinical disease to acute heart failure and suddencardiac death. Cardiovascular magnetic resonance(CMR) has the capability to differentiate between thevarious forms of myocardial injuries (e.g. edema,hyperemia and fibrosis). In the late 90s we developedan approach for the noninvasive detection of acutemyocarditis by CMR. In 2008/09 we published thenoninvasive detection of myocardial edema and thecapability of a multi-sequential approach for followup.(1)Myocardial inflammation also has a high prognosticimpact in different systemic diseases. Howeverearly assessment is difficult. We used CMR technologyin patients with systemic lupus erythematosus andChurg Strauss syndrome and were able to detectmyocardial involvement in those patients with preservedleft-ventricular function. (2) It is well known,that that development of fibrosis is of potential prognosticimpact in hypertrophy. Using contrastenhanced CMR we were able do differentiate the patternin various non-ischemic disease (3) and visualizefibrotic tissue in hypertrophy caused by different diseases(4) Furthermore we tried to get insight the gender-relatedremodeling process in hypertrophic cardiomyopathy.(5)Coronary Artery Disease and ArteriosclerosisThe detection of coronary artery stenosis is a growingfield in CMR. Quantitative analysis of perfusion is acrucial step for evaluation of significant ischemia anddevelopment of new therapeutic strategies. In 2009we could show that the lipid-apheresis has an impacton myocardial perfusion in young patients with elevatedLPa. In 2009 we published, that the quantitativedual bolus perfusion is of higher accuracy having thepotential to reduce the sample size. The field is ourstep into Ultra-High-Field research. In collaboration212 The Experimental and Clinical Research Center
Dr. André RudolphDr. med. Dipl.-Phys. Wolfgang UtzDr. Ralf WassmuthDr. Anja ZagrosekGraduate StudentsSascha AischeSana El-MammoudHoang GiangMaria KraussHannes KutzaMartin PofahlMarcel ProthmannJuius TraberTechnical AssistantsDenise KleindienstKerstin KretschelEvelyn PolzinStudy nurse/Project assistanceAnnette Köhlerwith the University of Oxford we published our firstpaper on CMR-driven infarct-detection in mices. (6)We are working on establishing the method at theMDC, Technical improvement will take place at all levelsof research in a strong collaboration with thegroup of the Ultra-Highfield-FacilitySelected publicationsZagrosek A, Abdel-Aty H, Boyé P, Wassmuth, R. Messroghli, DR. Utz, W.Rudolph, A. Bohl, S. Dietz, R. Schulz-Menger, J. Cardiac MagneticResonance Monitors Reversible and Irreversible Myocardial Injury inMyocarditis. J Am Coll Cardiol CVI 2009;2(2):131-138Bohl S, Wassmuth R, Abdel-Aty H, Rudolph, A. Messroghli, D. Dietz, R.Schulz-Menger, J.Delayed enhancement cardiac magnetic resonanceimaging reveals typical patterns of myocardial injury in patients with variousforms of non-ischemic heart disease. Int J Cardiovasc Imaging. Aug2008;24(6):597-607.Rudolph A, Abdel-Aty H, Bohl S, Boye, P. Zagrosek, A. Dietz, R. Schulz-Menger, J. Noninvasive detection of fibrosis applying contrast-enhancedcardiac magnetic resonance in different forms of left ventricular hypertrophyrelation to remodeling. J Am Coll Cardiol. Jan 20 2009;53(3):284-291.Schulz-Menger J, Abdel-Aty H, Rudolph A, Elgeti, T. Messroghli, D. Utz, W.Boye, P. Bohl, S. Busjahn, A. Hamm, B. Dietz, R. Gender-specific differencesin left ventricular remodelling and fibrosis in hypertrophic cardiomyopathy:Insights from cardiovascular magnetic resonance. Eur J Heart Fail.Sep 2008;10(9):850-854.Bohl S, Lygate CA, Barnes H, Medway, D. J. Stork, L. A. Schulz-Menger, J.Neubauer, S. Schneider, J. E.Advanced Methods for Quantification ofInfarct Size in Mice Using Three-Dimensional High-Field Late GadoliniumEnhancement MRI. Am J Physiol Heart Circ Physiol. Feb 13 2009.The Experimental and Clinical Research Center 213
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Research Report 2010MAX DELBRÜCK C
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ContentInhaltContentInhalt.........
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Surgical OncologyPeter M. Schlag...
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at the MDC. The role of the institu
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in discovering genes that contribut
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The ECRC offers research space and
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etween disciplines such as biology,
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approaches from bioinformatics/syst
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von Humboldt Foundation (AvH). The
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organization to a larger, multi-fac
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Cardiovascular and Metabolic Diseas
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electrical signals. More recent wor
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Basic Cardiovascular FunctionStruct
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Figure 2: SORLA and sortilin in neu
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Annette Hammes(Delbrück Fellow)Str
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Ingo L. MoranoStructure of the Grou
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Figure 3. Membrane resealing assay
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Michael GotthardtStructure of the G
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Structure of the GroupSalim Seyfrie
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Structure of the GroupFerdinand le
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Francesca M. SpagnoliStructure of t
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Structure of the GroupKai M. Schmid
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Genetics and Pathophysiology of Car
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Figure 2. Planariato experimentally
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Norbert HübnerStructure of the Gro
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Structure of the GroupGroup LeaderF
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Figure 2. Omega-3 fatty acids prote
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Structure of the GroupDominik N. M
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Rainer DietzStructure of the GroupG
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Figure 2. Cardiac-restricted ablati
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Ludwig ThierfelderStructure of the
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standing of the molecular and cellu
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Structure of the GroupThoralf Niend
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Michael BaderStructure of the Group
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Natriuretic peptide systemJens Butt
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Structure of the GroupZsuzsanna Izs
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Young-Ae LeeStructure of the GroupG
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Structure of the GroupMatthias Selb
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Matthew PoyStructure of the GroupGr
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Jana WolfStructure of the GroupGrou
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Structure of the GroupGroup LeaderD
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Cancer Research ProgramKrebsforschu
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are responsible for the emergence o
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tral component of the canonical Wnt
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lead to an aberrant constitutive ac
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How Notch- and TGFβ signaling casc
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tures of the chronic phase in human
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oped a new safeguard that is based
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Graduate StudentsSeda Cöl ArslanCa
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investigation, as is the cause of c
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Graduate StudentsÖzlem Akilli Özt
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onment, the (cancer) stem cell nich
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The pluripotent state of murine and
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In the morula of the early mouse em
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Graduate StudentsRami Hamscho*Qingb
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esis and granulopoiesis. We showed
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URE ∆/∆ mice regularly develope
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PD Dr. Wolfgang Walther (GroupLeade
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For the delivery of naked DNA into
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ACBDMyc and FoxO transcription fact
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Graduate StudentsKatrin BagolaHolge
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Heinemann, we could also identify t
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Above: Tip of chromosom3L showing t
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Graduate StudentsSarbani Bhattachar
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vesicle transport to the Golgi. Our
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acbFigure 1a: EHD2 is tubulatingpho
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KnowledgeProbabilitiesknownPossible
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Graduate and undergraduatestudentsU
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successive oncogenic mutations. We
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CXCR5 drives the development of ect
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Graduate and undergraduatestudentsW
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Graduate andUndergraduate StudentsM
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Angela MensenStefanie WittstockBjö
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deficient mice, both major effector
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ant of CD3 delta coding for a 45-me
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Robert KudernatschLi-Min LiuAna Mil
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Sebastian GüntherTechnical Assista
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Graduate StudentsJana RolffAnnika W
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with murine hepatocytes showed morp
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Function and Dysfunction of the Ner
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The Neuroscience Department also es
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the coming years, Björn Schröder
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mice. Further analysis of the funct
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Signaling Pathways and Mechanisms i
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Control Olig3 -/-ABFigure 2. Geneti
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Thomas J. JentschStructure of the G
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Figure 2. Cellular model for ionic
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Structure of the GroupGroup LeaderF
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paired-pulse facilitation, less dep
Page 188 and 189: Gary R. LewinStructure of the Group
Page 190 and 191: Model summarizing the three waves o
Page 192 and 193: Structure of the GroupInes Ibañez-
Page 194 and 195: Jochen C. MeierStructure of the Gro
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Page 198 and 199: Structure of the GroupJan Siemens(S
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Page 202 and 203: Imaging of the Living BrainStructur
Page 204 and 205: Pathophysiological Mechanisms of Ne
Page 206 and 207: Figure 2. Iba1 positive microglia c
Page 208 and 209: Erich E. WankerStructure of the Gro
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Page 215 and 216: Berlin Institute of Medical Systems
Page 217 and 218: etes, metabolic diseases and neurod
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Page 221 and 222: Technical AssistantsClaudia Langnic
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Page 230 and 231: his patients, and a basic research
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Page 234 and 235: Structure of the GroupSimone Spuler
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Page 240 and 241: Maik GollaschStructure of the Group
Page 243 and 244: Technology PlatformsComputational B
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Page 253 and 254: Left: Inside view of a FACSAria2 (f
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Page 272 and 273: SeminarsSeminare2008Speaker Institu
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Page 276 and 277: 2009Speaker Institute TitleDavid G.
Page 278 and 279: Speaker Institute TitleJuri Rappsil
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Prof. Dr. Renato ParoCenter of Bios
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Staff CouncilThe Staff Council is i
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Type of Financing/Art der Finanzier
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Research Projects 2008-2009Forschun
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CIC-5 Regulation und Endocytose am
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MDCMAX-DELBRÜCK-CENTRUMFÜR MOLEKU
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Index 275Bröske, A. . . . . . . .
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Index 277Gross, V. . . . . . . . .
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Index 279Kur, E. . . . . . . . . .
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Index 281Piano, F. . . . . . . . .
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Index 283Smink, J. . . . . . . . .
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Campus MapCampusplanRobert-Rössle-
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How to find your way to the MDCDer
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Research Report 2010 - MDC

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