Research Report 2010 - MDC

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ContentInhaltContentInhalt..................................................................................................................................................................................................IIDirector's introduction by Walter RosenthalBuilding our future on existing strengths: Extending the path from basic scienceto clinical medicineEinleitung Walter RosenthalDen Weg von der Grundlagenforschung in die klinische Medizin ausbauen:Entwicklung und Stärkung des vorhandenen Potentials.............................................................................................................................................................................................................. VIIICardiovascular and Metabolic Disease ResearchHerz-Kreislauf- und Stoffwechselerkrankungen ....................................... 1Coordinator: Thomas E. WillnowBasic Cardiovascular FunctionMolecular Cardiovascular ResearchThomas E. Willnow ...................................................................................................................................................................... 6Molecular Mechanisms in Embryonic Forebrain DevelopmentAnnette Hammes (Delbrück Fellow).................................................................................................................................... 10Molecular Muscle PhysiologyIngo L. Morano............................................................................................................................................................................... 12Neuromuscular and Cardiovascular Cell BiologyMichael Gotthardt ....................................................................................................................................................................... 16Epithelial Morphogenesis and Zebrafish GeneticsSalim Seyfried ................................................................................................................................................................................ 18Angiogenesis and Cardiovascular PathologyFerdinand le Noble....................................................................................................................................................................... 20Molecular and Cellular Basis of Embryonic DevelopmentFrancesca M. Spagnoli................................................................................................................................................................ 22Developmental Biology and Pathophysiology of the KidneyKai M. Schmidt-Ott ...................................................................................................................................................................... 24Genetics and Pathophysiology of Cardiovascular DiseasesSystems Biology of Gene Regulatory ElementsNikolaus Rajewsky........................................................................................................................................................................ 26Medical Genomics and Genetics of Complex Cardiovascular DiseasesNorbert Hübner ............................................................................................................................................................................ 30Hypertension, Vascular Disease, Genetics, and NephrologyFriedrich C. Luft.............................................................................................................................................................................. 32II Content
Mechanisms of Hypertension-Induced Target Organ DamageDominik N. Müller (Delbrück Fellow)................................................................................................................................... 36Clinical CardiologyRainer Dietz..................................................................................................................................................................................... 38Cardiovascular Molecular GeneticsLudwig Thierfelder....................................................................................................................................................................... 42Magnetic ResonanceThoralf Niendorf ........................................................................................................................................................................... 46Cardiovascular HormonesMichael Bader ................................................................................................................................................................................ 48Mobile DNAZsuzsanna Izsvák .......................................................................................................................................................................... 52Genetics of Allergic DiseaseYoung-Ae Lee.................................................................................................................................................................................. 54Cell Signaling and Mass SpectrometryMatthias Selbach.......................................................................................................................................................................... 56microRNAs and Mechanisms of Metabolic DiseasesMatthew Poy .................................................................................................................................................................................. 58Mathematical Modelling of Cellular SystemsJana Wolf.......................................................................................................................................................................................... 60RNA Biology and Post-transcriptional regulationMarkus Landthaler....................................................................................................................................................................... 62Cancer ResearchKrebsforschungsprogramm ..................................................................................................................... 65Coordinator: Claus ScheidereitSignaling Pathways, Cell and Tumor BiologySignal Transduction in Tumor CellsClaus Scheidereit .......................................................................................................................................................................... 78Signals Provided by Wnt/β-catenin and Met/Gab1/Shp2 in Development and CancerWalter Birchmeier ........................................................................................................................................................................ 82Signaling Mechanisms in Embryonic Stem CellsDaniel Besser (Delbrück Fellow)............................................................................................................................................. 86Genetics of Tumor Progression and MetastasisUlrike Ziebold ................................................................................................................................................................................. 88Cell Differentiation and TumorigenesisAchim Leutz .................................................................................................................................................................................... 90Cancer, Stem Cells, and Transcription FactorsFrank Rosenbauer ........................................................................................................................................................................ 94Content III
Page 1: Research Report 2010MAX DELBRÜCK C
Page 6 and 7: Surgical OncologyPeter M. Schlag...
Page 11 and 12: at the MDC. The role of the institu
Page 13 and 14: in discovering genes that contribut
Page 16 and 17: The ECRC offers research space and
Page 18 and 19: etween disciplines such as biology,
Page 20 and 21: approaches from bioinformatics/syst
Page 23 and 24: von Humboldt Foundation (AvH). The
Page 25: organization to a larger, multi-fac
Page 28 and 29: Cardiovascular and Metabolic Diseas
Page 30 and 31: electrical signals. More recent wor
Page 32 and 33: Basic Cardiovascular FunctionStruct
Page 34 and 35: Figure 2: SORLA and sortilin in neu
Page 36 and 37: Annette Hammes(Delbrück Fellow)Str
Page 38 and 39: Ingo L. MoranoStructure of the Grou
Page 40 and 41: Figure 3. Membrane resealing assay
Page 42 and 43: Michael GotthardtStructure of the G
Page 44 and 45: Structure of the GroupSalim Seyfrie
Page 46 and 47: Structure of the GroupFerdinand le
Page 48 and 49: Francesca M. SpagnoliStructure of t
Page 50 and 51: Structure of the GroupKai M. Schmid
Page 52 and 53: Genetics and Pathophysiology of Car
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Figure 2. Planariato experimentally
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Norbert HübnerStructure of the Gro
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Structure of the GroupGroup LeaderF
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Figure 2. Omega-3 fatty acids prote
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Structure of the GroupDominik N. M
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Rainer DietzStructure of the GroupG
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Figure 2. Cardiac-restricted ablati
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Ludwig ThierfelderStructure of the
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standing of the molecular and cellu
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Structure of the GroupThoralf Niend
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Michael BaderStructure of the Group
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Natriuretic peptide systemJens Butt
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Structure of the GroupZsuzsanna Izs
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Young-Ae LeeStructure of the GroupG
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Structure of the GroupMatthias Selb
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Matthew PoyStructure of the GroupGr
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Jana WolfStructure of the GroupGrou
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Structure of the GroupGroup LeaderD
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Cancer Research ProgramKrebsforschu
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are responsible for the emergence o
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tral component of the canonical Wnt
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lead to an aberrant constitutive ac
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How Notch- and TGFβ signaling casc
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tures of the chronic phase in human
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oped a new safeguard that is based
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Graduate StudentsSeda Cöl ArslanCa
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investigation, as is the cause of c
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Graduate StudentsÖzlem Akilli Özt
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onment, the (cancer) stem cell nich
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The pluripotent state of murine and
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In the morula of the early mouse em
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Graduate StudentsRami Hamscho*Qingb
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esis and granulopoiesis. We showed
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URE ∆/∆ mice regularly develope
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PD Dr. Wolfgang Walther (GroupLeade
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For the delivery of naked DNA into
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ACBDMyc and FoxO transcription fact
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Graduate StudentsKatrin BagolaHolge
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Heinemann, we could also identify t
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Above: Tip of chromosom3L showing t
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Graduate StudentsSarbani Bhattachar
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vesicle transport to the Golgi. Our
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acbFigure 1a: EHD2 is tubulatingpho
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KnowledgeProbabilitiesknownPossible
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Graduate and undergraduatestudentsU
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successive oncogenic mutations. We
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CXCR5 drives the development of ect
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Graduate and undergraduatestudentsW
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Graduate andUndergraduate StudentsM
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Angela MensenStefanie WittstockBjö
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deficient mice, both major effector
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ant of CD3 delta coding for a 45-me
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Robert KudernatschLi-Min LiuAna Mil
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Sebastian GüntherTechnical Assista
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Graduate StudentsJana RolffAnnika W
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with murine hepatocytes showed morp
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Function and Dysfunction of the Ner
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The Neuroscience Department also es
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the coming years, Björn Schröder
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mice. Further analysis of the funct
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Signaling Pathways and Mechanisms i
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Control Olig3 -/-ABFigure 2. Geneti
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Thomas J. JentschStructure of the G
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Figure 2. Cellular model for ionic
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Structure of the GroupGroup LeaderF
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paired-pulse facilitation, less dep
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Gary R. LewinStructure of the Group
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Model summarizing the three waves o
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Structure of the GroupInes Ibañez-
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Jochen C. MeierStructure of the Gro
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Björn Christian SchroederStructure
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Structure of the GroupJan Siemens(S
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Structure of the GroupGroup LeaderD
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Imaging of the Living BrainStructur
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Pathophysiological Mechanisms of Ne
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Figure 2. Iba1 positive microglia c
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Erich E. WankerStructure of the Gro
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Scientific-Technical StaffAnja Frit
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Structure of the GroupJan Bieschke(
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Berlin Institute of Medical Systems
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etes, metabolic diseases and neurod
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A number of MDC investigators have
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Technical AssistantsClaudia Langnic
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has become a standardized data flow
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Phylogeny of cellulase genes from P
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Experimental and Clinical Research
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his patients, and a basic research
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The ultrahigh field MR facility was
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Structure of the GroupSimone Spuler
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Ralph KettritzStructure of the Grou
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Structure of the GroupJeanette Schu
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Maik GollaschStructure of the Group
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Technology PlatformsComputational B
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projects/ard/] to detect repeats li
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Simulation of line-scan images of C
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Development of an MRM method for qu
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mobility or turnover of the underly
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Left: Inside view of a FACSAria2 (f
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Examples fort the use of EM methods
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Oviducts lined up in pre-implantati
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Academic Appointments 2008-2009Beru
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Buch which is part of the Excellenc
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“Bioinformatics in Quantitative B
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Delbrück FellowsDelbrück-Stipendi
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Yinth Andrea Bernal-Sierra, a PhD s
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Congresses and Scientific MeetingsK
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SeminarsSeminare2008Speaker Institu
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Speaker Institute TitleKiyoshi Mori
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2009Speaker Institute TitleDavid G.
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Speaker Institute TitleJuri Rappsil
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The Helmholtz AssociationDie Helmho
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The Berlin-Buch CampusDer Campus Be
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the MDC, the existing collaboration
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Prof. Dr. Gary R. LewinMDC Berlin-B
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Prof. Dr. Renato ParoCenter of Bios
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Staff CouncilThe Staff Council is i
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Type of Financing/Art der Finanzier
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Research Projects 2008-2009Forschun
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CIC-5 Regulation und Endocytose am
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MDCMAX-DELBRÜCK-CENTRUMFÜR MOLEKU
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Index 275Bröske, A. . . . . . . .
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Index 277Gross, V. . . . . . . . .
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Index 279Kur, E. . . . . . . . . .
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Index 281Piano, F. . . . . . . . .
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Index 283Smink, J. . . . . . . . .
Page 312 and 313:
Campus MapCampusplanRobert-Rössle-
Page 314:
How to find your way to the MDCDer
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Research Report 2010 - MDC

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