Research Report 2010 - MDC

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“Bioinformatics in Quantitative Biology“. He and his colleaguesdevelop computer methods and strategies toevaluate data from gene analyses, mass spectrometryand imaging procedures. The objective is to achieve abetter understanding of biological systems.Dr. Stefan Kempa from the MPI of Molecular Plant Physiology,Potsdam, came to the Berlin Institute for MedicalSystems Biology (BIMSB) of the MDC in April 2009. Heheads the technology platform “Integrative Proteomicsand Metabolomics”. It uses the latest technologies ofmass spectrometry to investigate metabolic processesand the proteome in cell cultures, organs, and wholeorganisms.The physicist Professor Thoralf Niendorf has beenappointed to the chair for Experimental Ultra High FieldMagnetic Resonance Imaging (MRI) at the Experimentaland Clinical Research Center (ECRC) of MDC and Charité.The specialist for imaging tech-niques from RWTHAachen University became head of the MRI facility ofECRC on Campus Berlin-Buch on August 10, 2009. Theresearch facility, which has one of the world’s strongestmagnetic resonance tomographs, a 7 Tesla whole-bodyMRI scanner, was dedicated in January 2009 by FederalEducation and Research minister Annette Schavan.The neuroscientist Dr. James Poulet has been appointedto the Berlin excellence cluster and as of July 1, 2009began work there in Berlin-Mitte. Dr. Poulet, whoseresearch is being funded by the MDC, which along withother institutions is participating in NeuroCure, is studyinghow neuronal regulatory circuits control behavior.Until the summer of 2009 he was a postdoc at École PolytechniqueFédérale de Lausanne, Switzerland, where hesucceeded in recording intracellular activity between twonerve cells in the cerebral cortex of a conscious animal forthe first time.Formerly at the Humboldt University of Berlin, Dr. JanaWolf joined the MDC as a junior group leader as part ofthe Helmholtz Association’s initiative “Systems Biology”.Dr. Wolf’s group will receive additional funding throughthe BMBF’s program “Research Units in Systems Biology(FORSYS) ”. Her work focuses on mathematical modelingof cellular processes.MDC gekommen und baut dort die Technologieplattform‚Bioinformatik und Quantitative Biologie’auf. Er und seineMitarbeiter entwickeln Computermethoden und Analysestrategien,um die Daten von Genanalysen, Massenspektrometrieund bildgebenden Verfahren auswerten zu können.Ziel ist ein besseres Verständnis biologischer Systeme.Dr. Stefan Kempa vom MPI für Molekulare Pflanzenphysiologie,Potsdam, ist im April 2009 an das Berlin Institute forMedical Systems Biology (BIMSB) des MDC gekommen undbaut dort die Technologieplattform „Integrative Proteomicsand Metabolomics“ auf. Dort setzt er die neuestenTechnologien der Massenspektrometrie ein, um Stoffwechselvorgängeund das Proteom in Zellkulturen, Organen undganzen Organismen zu untersuchen.Der Physiker Prof. Thoralf Niendorf ist auf einen Lehrstuhlfür Experimentelle Ultrahochfeld-Magnetresonanz-Tomographie(MRT) an das Experimental and Clinical ResearchCenter (ECRC) des MDC und der Charité berufen worden.Der Spezialist für bildgebende Verfahren von der Rheinisch-Westfälischen Technischen Hochschule (RWTH) Aachenhat im August 2009 die Leitung der MR-Anlage des ECRCauf dem Campus Berlin-Buch übernommen. Die Forschungsanlagemit einem der weltweit stärksten Magnetresonanz-Tomographen,einem 7-Tesla Ganzkörper-MRT,war im Januar 2009 von BundesforschungsministerinAnnette Schavan eingeweiht worden.Der Neurowissenschaftler Dr. James Poulet ist an das BerlinerExzellenzcluster „NeuroCure“ berufen worden und hatdort in Berlin-Mitte Anfang Juli 2009 seine Arbeit aufgenommen.Dr. Poulet, der über das MDC finanziert wird,erforscht wie neuronale Regelkreise Verhalten kontrollieren.Er war bis Sommer 2009 Postdoktorand an der ÉcolePolytechnique Fédérale de Lausanne, Schweiz, wo es ihmals erstem gelang, die intrazellluläre Aktivität zweier Nervenzellender Großhirnrinde im wachen Tier aufzuzeichnen.Im Rahmen der Initiative Systembiologie der Helmholtz-Gemeinschaft wechselte Dr. Jana Wolf, Humboldt-Universitätzu Berlin, als Nachwuchsgruppenleiterin an das MDC.Die Nachwuchsgruppe wird zusätzlich über die BMBF Ausschreibung„Forschungseinheiten der Systembiologie-FOR-SYS“ finanziert. Ihre Arbeit konzentriert sich auf die mathematischeModellierung zellulärer Prozesse.238 Academics
AwardsPreise20082009Martin BergmannWilhelm P. Winterstein-Preis, Deutsche Herzstiftung e. V.Gudrun ErzgräberBundesverdienstkreuz, Bundesrepublik DeutschlandMartin Janz und Stephan MathasCurt-Meyer-Gedächtnispreis, BerlinerKrebsgesellschaft e. V.Friedrich LuftFranz-Volhard-Medaille, Deutsche Gesellschaft fürNephrologieRobert Tigerstedt Award, International Society ofHypertensionLehrbär, Reformstudiengang Medizin der Charite –Universitätsmedizin BerlinNikolaus Rajewsky1. Forschungspreis, Deutsche Gesellschaft fürGentherapie e. V.Jan-Erik SiemensSofja Kovalevskaja-Preis, Alexander vonHumboldt-StiftungNorbert HübnerWissenschaftspreis für „MedizinischeGrundlagenforschung“, GlaxoSmithKline StiftungFriedrich LuftRoss McIntyre Award, University of NebraskaRaluca NiesnerRahel-Hirsch-Stipendium, Charité –Universitätsmedizin BerlinKlaus RajewskyMax-Delbrück-MedailleJens ReichCarl-Friedrich-von-Weizsäcker-Preis, NationaleAkademie der Wissenschaften Leopoldina undStifterverband für die Deutsche WissenschaftFrancesca SpagnoliGrant: European Research Council (ERC)Thomas WillnowEhrendoktorwürde, Universität Aarhus, DänemarkErich Wanker, Ulrich Stelzl, Christian Hänig,Gautam Chaurasia, Matthias FutschikErwin-Schrödinger-Preis, Hermann-von-Helmholtz-Gemeinschaft Deutscher Forschungszentren e. V.(Photo: E. Fesseler/Copyright: Helmholtz-Gemeinschaft Deutscher Forschungszentren)Recipients of the Erwin Schrödinger Prize 2008Prof. Erich Wanker (MDC), Dr. Ulrich Stelzl (MPI forMolecular Genetics), Prof. Jürgen Mlynek (Presidentof the Helmholtz Association), Dipl.-Ing. ChristianHänig (MDC), Gautam Chaurasia, M.Sc., and Dr.Matthias Futschik (both HUB)(from left to right)Preisträger des Erwin Schrödinger-Preis 2008Prof. Erich Wanker (MDC), Dr. Ulrich Stelzl (MPI fürmolekulare Genetik), Prof. Jürgen Mlynek (Präsidentder Helmholtz-Gemeinschaft), Dipl.-Ing. ChristianHänig (MDC), M.Sc. Gautam Chaurasia und Dr.Matthias Futschik (beide HUB)(v.l.)Academics 239
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Research Report 2010MAX DELBRÜCK C
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ContentInhaltContentInhalt.........
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Surgical OncologyPeter M. Schlag...
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at the MDC. The role of the institu
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in discovering genes that contribut
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The ECRC offers research space and
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etween disciplines such as biology,
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approaches from bioinformatics/syst
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von Humboldt Foundation (AvH). The
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organization to a larger, multi-fac
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Cardiovascular and Metabolic Diseas
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electrical signals. More recent wor
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Basic Cardiovascular FunctionStruct
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Figure 2: SORLA and sortilin in neu
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Annette Hammes(Delbrück Fellow)Str
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Ingo L. MoranoStructure of the Grou
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Figure 3. Membrane resealing assay
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Michael GotthardtStructure of the G
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Structure of the GroupSalim Seyfrie
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Structure of the GroupFerdinand le
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Francesca M. SpagnoliStructure of t
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Structure of the GroupKai M. Schmid
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Genetics and Pathophysiology of Car
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Figure 2. Planariato experimentally
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Norbert HübnerStructure of the Gro
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Structure of the GroupGroup LeaderF
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Figure 2. Omega-3 fatty acids prote
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Structure of the GroupDominik N. M
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Rainer DietzStructure of the GroupG
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Figure 2. Cardiac-restricted ablati
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Ludwig ThierfelderStructure of the
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standing of the molecular and cellu
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Structure of the GroupThoralf Niend
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Michael BaderStructure of the Group
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Natriuretic peptide systemJens Butt
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Structure of the GroupZsuzsanna Izs
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Young-Ae LeeStructure of the GroupG
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Structure of the GroupMatthias Selb
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Matthew PoyStructure of the GroupGr
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Jana WolfStructure of the GroupGrou
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Structure of the GroupGroup LeaderD
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Cancer Research ProgramKrebsforschu
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are responsible for the emergence o
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tral component of the canonical Wnt
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lead to an aberrant constitutive ac
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How Notch- and TGFβ signaling casc
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tures of the chronic phase in human
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oped a new safeguard that is based
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Graduate StudentsSeda Cöl ArslanCa
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investigation, as is the cause of c
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Graduate StudentsÖzlem Akilli Özt
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onment, the (cancer) stem cell nich
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The pluripotent state of murine and
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In the morula of the early mouse em
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Graduate StudentsRami Hamscho*Qingb
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esis and granulopoiesis. We showed
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URE ∆/∆ mice regularly develope
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PD Dr. Wolfgang Walther (GroupLeade
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For the delivery of naked DNA into
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ACBDMyc and FoxO transcription fact
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Graduate StudentsKatrin BagolaHolge
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Heinemann, we could also identify t
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Above: Tip of chromosom3L showing t
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Graduate StudentsSarbani Bhattachar
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vesicle transport to the Golgi. Our
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acbFigure 1a: EHD2 is tubulatingpho
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KnowledgeProbabilitiesknownPossible
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Graduate and undergraduatestudentsU
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successive oncogenic mutations. We
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CXCR5 drives the development of ect
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Graduate and undergraduatestudentsW
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Graduate andUndergraduate StudentsM
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Angela MensenStefanie WittstockBjö
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deficient mice, both major effector
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ant of CD3 delta coding for a 45-me
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Robert KudernatschLi-Min LiuAna Mil
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Sebastian GüntherTechnical Assista
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Graduate StudentsJana RolffAnnika W
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with murine hepatocytes showed morp
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Function and Dysfunction of the Ner
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The Neuroscience Department also es
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the coming years, Björn Schröder
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mice. Further analysis of the funct
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Signaling Pathways and Mechanisms i
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Control Olig3 -/-ABFigure 2. Geneti
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Thomas J. JentschStructure of the G
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Figure 2. Cellular model for ionic
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Structure of the GroupGroup LeaderF
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paired-pulse facilitation, less dep
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Gary R. LewinStructure of the Group
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Model summarizing the three waves o
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Structure of the GroupInes Ibañez-
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Jochen C. MeierStructure of the Gro
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Björn Christian SchroederStructure
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Structure of the GroupJan Siemens(S
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Structure of the GroupGroup LeaderD
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Imaging of the Living BrainStructur
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Pathophysiological Mechanisms of Ne
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Figure 2. Iba1 positive microglia c
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Erich E. WankerStructure of the Gro
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Scientific-Technical StaffAnja Frit
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Structure of the GroupJan Bieschke(
Page 215 and 216: Berlin Institute of Medical Systems
Page 217 and 218: etes, metabolic diseases and neurod
Page 219 and 220: A number of MDC investigators have
Page 221 and 222: Technical AssistantsClaudia Langnic
Page 223 and 224: has become a standardized data flow
Page 225: Phylogeny of cellulase genes from P
Page 228 and 229: Experimental and Clinical Research
Page 230 and 231: his patients, and a basic research
Page 232 and 233: The ultrahigh field MR facility was
Page 234 and 235: Structure of the GroupSimone Spuler
Page 236 and 237: Ralph KettritzStructure of the Grou
Page 238 and 239: Structure of the GroupJeanette Schu
Page 240 and 241: Maik GollaschStructure of the Group
Page 243 and 244: Technology PlatformsComputational B
Page 245 and 246: projects/ard/] to detect repeats li
Page 247 and 248: Simulation of line-scan images of C
Page 249 and 250: Development of an MRM method for qu
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Page 253 and 254: Left: Inside view of a FACSAria2 (f
Page 255 and 256: Examples fort the use of EM methods
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Page 260 and 261: Academic Appointments 2008-2009Beru
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Page 266 and 267: Delbrück FellowsDelbrück-Stipendi
Page 268 and 269: Yinth Andrea Bernal-Sierra, a PhD s
Page 270 and 271: Congresses and Scientific MeetingsK
Page 272 and 273: SeminarsSeminare2008Speaker Institu
Page 274 and 275: Speaker Institute TitleKiyoshi Mori
Page 276 and 277: 2009Speaker Institute TitleDavid G.
Page 278 and 279: Speaker Institute TitleJuri Rappsil
Page 280 and 281: The Helmholtz AssociationDie Helmho
Page 282 and 283: The Berlin-Buch CampusDer Campus Be
Page 284: the MDC, the existing collaboration
Page 287 and 288: Prof. Dr. Gary R. LewinMDC Berlin-B
Page 289 and 290: Prof. Dr. Renato ParoCenter of Bios
Page 291 and 292: Staff CouncilThe Staff Council is i
Page 293 and 294: Type of Financing/Art der Finanzier
Page 295 and 296: Research Projects 2008-2009Forschun
Page 297 and 298: CIC-5 Regulation und Endocytose am
Page 299 and 300: MDCMAX-DELBRÜCK-CENTRUMFÜR MOLEKU
Page 301 and 302: Index 275Bröske, A. . . . . . . .
Page 303 and 304: Index 277Gross, V. . . . . . . . .
Page 305 and 306: Index 279Kur, E. . . . . . . . . .
Page 307 and 308: Index 281Piano, F. . . . . . . . .
Page 309 and 310: Index 283Smink, J. . . . . . . . .
Page 312 and 313: Campus MapCampusplanRobert-Rössle-
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How to find your way to the MDCDer
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Research Report 2010 - MDC

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