Research Report 2010 - MDC

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Congresses and Scientific MeetingsKongresse und Wissenschaftliche Tagungen200811 January Max Delbrück Lecture , Prof. Michael Botchan, University of California, Berkeley, USAOrganizer: Prof. M. Gossen, MDC18 January Neujahrsempfang des Campus Berlin-BuchOrganizer: MDC/BBB GmbH08 February Max Delbrück Lecture, Prof. Ruth Lehmann, Developmental Genetics Program, Skirball Instituteand Howard Hughes Medical Institute New York, University School of Medicine, New York, USAOrganizer: Prof. N. Rajewsky, MDC16 February HNO-Symposium des Helios KlinikumsOrganizer: Helios–Klinikum Berlin-Buch26-29 March International Conference “Invasion and Metatasis“Organizer: Prof. W. Birchmeier, MDC24-25 April LaborbaukonferenzOrganizer: R. Streckwall, MDC14-17 May International Conference „Development and Function of Somatosensation and Pain”Organizer: Prof. G. Lewin, MDC26-28 May International Symposium “Adoptive T Cell Therapy”Organizer: Prof. W. Uckert, MDC07 June 13. Bucher Nephrologisches SymposiumOrganizer: Prof. F. Luft, MDC/FVK12-14 June International Berlin Summer Meeting “Computational & Experimental Molecular Biology”Organizer: Prof. N. Rajewsky, MDC14 June Lange Nacht der WissenschaftenOrganizer: Campus Berlin-Buch17 June Max Delbrück Lecture, Prof. K. Chien, MGH Cardiovascular Research Center,Massachusetts General Hospital, Richard B. Simches Research Center, Boston, USAOrganizer: Dr. D. Besser, MDC19 - 21 June International Conference “Transposition and Animal Biotechnology”Organizer: Dr. Zs. Izsvak, MDC27 June Festveranstaltung zu Ehren der Verabschiedung von Dr. Gudrun Erzgräber, Geschäftsführerinder BBB GmbH und Verleihung des BundesverdienstkreuzesOrganizer: Campus Berlin-Buch07 -11 July Basis Gene Mapping /Linkage Analysis CourseOrganizer: Forschungsgruppe Bioinformatik, MDC mit Dr. M. Nothnagel, Uni Kiel11 July Max Delbrück Lecture, Dr. Helen H. Hobbs HHMI, UT Southwestern Medical Center Dallas, USAOrganizer: Dr. Daniel Besser, MDC08-10 October 15 th Annual Meeting of the German Society of Gene Therapy, DG-GT e.V. & 6 th AnnualWorkshop “Viral Vectors and Gene Therapy” of the Gesellschaft für Virologie, GfVOrganizer: Prof. W. Uckert, MDC mit Charité und HU Berlin29 October Symposium: Junior Group Leader Position Systems Biology am MDCOrganizer: Prof. N. Rajewsky, MDC29-30 October NMR-Symposium: “Challenging Biological Systems Systems by NMR Spectroscopy“Organizer: Prof. H. Oschkinat, FMP07 November Max Delbrück Lecture, Prof. Dr. Jonathan Weissman Howard Hughes MedicalInstitute San Francisco, USAOrganizer: Prof. Th. Sommer, MDC244 Academics
07-08 November 7. Bucher HämatologieforumOrganizer: Beckman Coulter GmbH + Prof. W.-D. Ludwig, RRK12-14 November International Symposium on Chemical BiochemistryOrganizer: Prof. Dr. H. Oschkinat, FMP01-02 December “Capital Market Day 2008“ Fa. Fresenius SE,Organizer: Bad Homburg04-05 December “Brain Tumor Meeting“Organizer: Helmut Kettenmann, MDC mit Helios Klinikum Berlin und Charité Campus,Virchow-Klinikum08 December Information workshop “EMBO: promoting excellence in the molecular life sciences in Europe”Speaker: Dr Jan Taplick, EMBO Deputy Executive Director, EMBO Fellowship ProgrammeManager and Information workshop ‘Career Pathways’Organizer: PhD Program at the MDC, Dr. O. Seumenicht and Dr. J. Droese10-12 December Berlin Brain Days 2008 veranstaltet von sieben, in Berlin angesiedelten,neurowissenschaftlichen Promovierendenprogrammen200920 January Neujahrsempfang des Campus Berlin-BuchOrganizer: MDC/BBB GmbH11 November -15 March Ausstellung mit Zeichnungen von Berliner Schülern anlässlich des 200. Geburtstages von DarwinOrganizer: Gläsernes Labor der BBB GmbH21 April - 30 June Ausstellung “Frauen in Naturwissenschaft und Technik”MDC FrauenbeauftragteOrganizer: Dr. H. Haase23-24 April Laborbaukonferenz R. StreckwallOrganizer: MDC12 June Wissenschaftshistorisches Kolloquium anläßlich des 80. Geburtstages vonProf. Dr. em. Heinz Bielka und des 70. Geburtstages von Prof. Dr. em. Jens ReichOrganizer: MDC13 June Lange Nacht der WissenschaftenOrganizer: Campus Berlin-Buch19 June Max Delbrück Lecture, Dr. Neal Copeland, Institute of Molecular and Cell Biology, SingaporeOrganizers: Carmen Birchmeier and Walter Birchmeier20 June 14. Bucher Nephrologisches SymposiumOrganizer: Prof. F. Luft, FVK03 July NEW MDC SCIENTISTS present their work Max Delbrück Center for Molecular Medicine (MDC),Organizer: Berlin Institute for Medical Systems Biology (BIMSB)10 July Max Delbrück Lecture , Dr. Stephen Cohen, Temasek Life Sciences Laboratory, SingaporeOrganizer: Prof. Th. Sommer, MDC22-26 September International EMBO Conference Series “Ubiquitin and Ubiquitin-like Modifiersin Health and Disease”Organizer: Prof. T. Sommer, MDC08-10 October International Berlin Summer Meeting “Computational & Experimental Molecular Biology”Organizer: Prof. N. Rajewsky, MDC09-13 November Basis Gene Mapping /Linkage Analysis Course Forschungsgruppe BioinformatikOrganizer: MDC mit Dr. M. Nothnagel, Uni Kiel2009 December Berlin Brain Days 2009 veranstaltet von sieben, in Berlin angesiedelten,neurowissenschaftlichen Promovierendenprogrammen.Academics 245
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Research Report 2010MAX DELBRÜCK C
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ContentInhaltContentInhalt.........
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Surgical OncologyPeter M. Schlag...
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at the MDC. The role of the institu
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in discovering genes that contribut
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The ECRC offers research space and
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etween disciplines such as biology,
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approaches from bioinformatics/syst
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von Humboldt Foundation (AvH). The
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organization to a larger, multi-fac
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Cardiovascular and Metabolic Diseas
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electrical signals. More recent wor
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Basic Cardiovascular FunctionStruct
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Figure 2: SORLA and sortilin in neu
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Annette Hammes(Delbrück Fellow)Str
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Ingo L. MoranoStructure of the Grou
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Figure 3. Membrane resealing assay
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Michael GotthardtStructure of the G
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Structure of the GroupSalim Seyfrie
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Structure of the GroupFerdinand le
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Francesca M. SpagnoliStructure of t
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Structure of the GroupKai M. Schmid
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Genetics and Pathophysiology of Car
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Figure 2. Planariato experimentally
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Norbert HübnerStructure of the Gro
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Structure of the GroupGroup LeaderF
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Figure 2. Omega-3 fatty acids prote
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Structure of the GroupDominik N. M
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Rainer DietzStructure of the GroupG
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Figure 2. Cardiac-restricted ablati
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Ludwig ThierfelderStructure of the
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standing of the molecular and cellu
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Structure of the GroupThoralf Niend
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Michael BaderStructure of the Group
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Natriuretic peptide systemJens Butt
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Structure of the GroupZsuzsanna Izs
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Young-Ae LeeStructure of the GroupG
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Structure of the GroupMatthias Selb
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Matthew PoyStructure of the GroupGr
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Jana WolfStructure of the GroupGrou
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Structure of the GroupGroup LeaderD
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Cancer Research ProgramKrebsforschu
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are responsible for the emergence o
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tral component of the canonical Wnt
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lead to an aberrant constitutive ac
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How Notch- and TGFβ signaling casc
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tures of the chronic phase in human
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oped a new safeguard that is based
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Graduate StudentsSeda Cöl ArslanCa
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investigation, as is the cause of c
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Graduate StudentsÖzlem Akilli Özt
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onment, the (cancer) stem cell nich
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The pluripotent state of murine and
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In the morula of the early mouse em
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Graduate StudentsRami Hamscho*Qingb
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esis and granulopoiesis. We showed
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URE ∆/∆ mice regularly develope
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PD Dr. Wolfgang Walther (GroupLeade
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For the delivery of naked DNA into
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ACBDMyc and FoxO transcription fact
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Graduate StudentsKatrin BagolaHolge
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Heinemann, we could also identify t
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Above: Tip of chromosom3L showing t
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Graduate StudentsSarbani Bhattachar
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vesicle transport to the Golgi. Our
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acbFigure 1a: EHD2 is tubulatingpho
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KnowledgeProbabilitiesknownPossible
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Graduate and undergraduatestudentsU
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successive oncogenic mutations. We
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CXCR5 drives the development of ect
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Graduate and undergraduatestudentsW
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Graduate andUndergraduate StudentsM
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Angela MensenStefanie WittstockBjö
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deficient mice, both major effector
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ant of CD3 delta coding for a 45-me
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Robert KudernatschLi-Min LiuAna Mil
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Sebastian GüntherTechnical Assista
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Graduate StudentsJana RolffAnnika W
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with murine hepatocytes showed morp
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Function and Dysfunction of the Ner
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The Neuroscience Department also es
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the coming years, Björn Schröder
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mice. Further analysis of the funct
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Signaling Pathways and Mechanisms i
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Control Olig3 -/-ABFigure 2. Geneti
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Thomas J. JentschStructure of the G
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Figure 2. Cellular model for ionic
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Structure of the GroupGroup LeaderF
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paired-pulse facilitation, less dep
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Gary R. LewinStructure of the Group
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Model summarizing the three waves o
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Structure of the GroupInes Ibañez-
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Jochen C. MeierStructure of the Gro
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Björn Christian SchroederStructure
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Structure of the GroupJan Siemens(S
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Structure of the GroupGroup LeaderD
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Imaging of the Living BrainStructur
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Pathophysiological Mechanisms of Ne
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Figure 2. Iba1 positive microglia c
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Erich E. WankerStructure of the Gro
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Scientific-Technical StaffAnja Frit
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Structure of the GroupJan Bieschke(
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Berlin Institute of Medical Systems
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etes, metabolic diseases and neurod
Page 219 and 220: A number of MDC investigators have
Page 221 and 222: Technical AssistantsClaudia Langnic
Page 223 and 224: has become a standardized data flow
Page 225: Phylogeny of cellulase genes from P
Page 228 and 229: Experimental and Clinical Research
Page 230 and 231: his patients, and a basic research
Page 232 and 233: The ultrahigh field MR facility was
Page 234 and 235: Structure of the GroupSimone Spuler
Page 236 and 237: Ralph KettritzStructure of the Grou
Page 238 and 239: Structure of the GroupJeanette Schu
Page 240 and 241: Maik GollaschStructure of the Group
Page 243 and 244: Technology PlatformsComputational B
Page 245 and 246: projects/ard/] to detect repeats li
Page 247 and 248: Simulation of line-scan images of C
Page 249 and 250: Development of an MRM method for qu
Page 251 and 252: mobility or turnover of the underly
Page 253 and 254: Left: Inside view of a FACSAria2 (f
Page 255 and 256: Examples fort the use of EM methods
Page 257: Oviducts lined up in pre-implantati
Page 260 and 261: Academic Appointments 2008-2009Beru
Page 262 and 263: Buch which is part of the Excellenc
Page 264 and 265: “Bioinformatics in Quantitative B
Page 266 and 267: Delbrück FellowsDelbrück-Stipendi
Page 268 and 269: Yinth Andrea Bernal-Sierra, a PhD s
Page 272 and 273: SeminarsSeminare2008Speaker Institu
Page 274 and 275: Speaker Institute TitleKiyoshi Mori
Page 276 and 277: 2009Speaker Institute TitleDavid G.
Page 278 and 279: Speaker Institute TitleJuri Rappsil
Page 280 and 281: The Helmholtz AssociationDie Helmho
Page 282 and 283: The Berlin-Buch CampusDer Campus Be
Page 284: the MDC, the existing collaboration
Page 287 and 288: Prof. Dr. Gary R. LewinMDC Berlin-B
Page 289 and 290: Prof. Dr. Renato ParoCenter of Bios
Page 291 and 292: Staff CouncilThe Staff Council is i
Page 293 and 294: Type of Financing/Art der Finanzier
Page 295 and 296: Research Projects 2008-2009Forschun
Page 297 and 298: CIC-5 Regulation und Endocytose am
Page 299 and 300: MDCMAX-DELBRÜCK-CENTRUMFÜR MOLEKU
Page 301 and 302: Index 275Bröske, A. . . . . . . .
Page 303 and 304: Index 277Gross, V. . . . . . . . .
Page 305 and 306: Index 279Kur, E. . . . . . . . . .
Page 307 and 308: Index 281Piano, F. . . . . . . . .
Page 309 and 310: Index 283Smink, J. . . . . . . . .
Page 312 and 313: Campus MapCampusplanRobert-Rössle-
Page 314: How to find your way to the MDCDer
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