Clinical Textbook of Addictive Disorders 3rd ed - R. Frances, S. Miller, A. Mack (Guilford, 2005) WW

PathologicalgamblingPathologicalgamblingKim et al. (2002) Paroxetine(Paxil)Grant et al.(2003)Paroxetine(Paxil)8 weeks with 1-week placebolead-in53 enrolled,41completers16 weeks 76 enrolled,45 completers51.7 mg(± 13.1)50 mg(± 8.3)Paroxetine groupsignificantly improvedcompared to placebo on CGIParoxetine and placebogroups with comparableimprovement on all measuresPathologicalgamblingSaiz-Ruiz et al.(2005)Sertraline(Zoloft)6 months 66 enrolled,37 completers95 mg Sertraline and placebo groupswith comparableimprovement to CCPGQCompulsivebuyingBlack et al.(2000)Fluvoxamine(Luvox)9 weeks with 1-week placebolead-in23 enrolled,18 completers220 mg Fluvoxamine and placebogroups with comparableimprovement on YBOCS-SVand CGICompulsivebuyingNinan et al.(2000)Fluvoxamine(Luvox)13 weeks 37 enrolled,23 completers215 mg(± 76.5)Fluvoxamine and placebogroups with comparableimprovement on YBOCS-CB, CGI, and GAFCompulsivebuyingKoran et al.(2003)Citalopram(Celexa)7-week openlabelfollowed by9 weeksrandomized24 enrolled,15 randomized42.1 mg(± 15.3)Citalopram groupsignificantly improvedcompared to placebo onYBOCS-SV and CGINote. PG-YBOCS, Yale–Brown Obsessive Compulsive Scale Modified for Pathological Gambling; YBOCS-SV, Yale–Brown Obsessive Compulsive Scale—Shopping Version;YBOCS-CB, Yale–Brown Obsessive Compulsive Scale Modified for Compulsive Buying; CGI, Clinical Global Impression scale; G-SAS, Gambling Symptom AssessmentScale; GAF, Global Assessment of Functioning; CARS-M, Clinician-Administered Rating Scale for Mania; CCPGQ, Criteria for Control of Pathological GamblingQuestionnaire.311