Clinical Textbook of Addictive Disorders 3rd ed - R. Frances, S. Miller, A. Mack (Guilford, 2005) WW

604 V. TREATMENTS FOR ADDICTIONSTABLE 26.1. Drug Interactions between Methadone or LAAM and Medications Usedto Treat Other Common Conditions in Opioid-Dependent PatientsIndicationInteraction with methadone or LAAMPsychotropic medicationsFluvoxamine Depression ↑ Methadone levels with potential toxicity(Eap et al., 1997)Desipramine Depression ↑ Desipramine levels (Gourevitch & Friedland,2000)Sertraline Depression ↑ Methadone levels without reported toxicity(Hamilton et al., 2000)Valproic acidCarbamazepineSeizure disorder, bipolaraffective disorderSeizure disorder, bipolaraffective disorderNone reported (Saxon et al., 1989)↓ Methadone levels (Eap et al., 2002)Other medicationsPhenytoin Seizure disorder ↓ Methadone levels (Eap et al., 2002)Phenobarbital Seizure disorder ↓ Methadone levels (Eap et al., 2002)Rifampin Tuberculosis ↓ Methadone levels (Raistrick et al., 1996)Rifabutin Tuberculosis No change in methadone levels (Brown et al.,1996)Fluconazole Fungal infection ↑ Methadone levels by ≈ 35%; clinicalsignificance unknown (Cobb et al., 1998)Ciprofloxacin Bacterial infection ↑ Methadone levels with toxicity reported(Herrlin et al., 2000)Zidovudine (AZT) HIV ↑ Methadone associated with increase in AZTlevels (McCance-Katz et al., 2002)Didanosine (ddI) HIV ↓ ddI levels by 63% (Rainey et al., 2000)Lamivudine HIV NoneLamivudine/zidovudineHIV None (Rainey et al., 2002)Stavudine (d4T) HIV None (Rainey et al., 2000)Abacavir HIV ↑ Methadone clearance (Sellers et al., 1999)(continued)