2012 EDUCATIONAL BOOK - American Society of Clinical Oncology

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Short- and Long-term Cardiovascular Complications of Cancer Treatment: Overview for the Practicing Oncologist Short- and Long-term Cardiovascular Complications of Cancer Treatment: Overview for the Practicing Oncologist Chetan Shenoy and Gretchen Kimmick ................................................................... 553 Recent Advances in Cardiotoxicity of Anticancer Therapies Marianne Ryberg ..................................................................................... 555 When Cancer Becomes Personal: The Physician’s View of Patient Care The Oncologist as the Patient with Cancer or Relative Teresa Gilewski, Martin Raber, and George W. Sledge Jr. ................................................... 561 Pediatric Oncology Advances in Infection Management in Pediatric Oncology Prolonged Febrile Neutropenia in the Pediatric Patient with Cancer Andrew Y. Koh. ...................................................................................... 565 Initial Management of Low-Risk Pediatric Fever and Neutropenia: Efficacy and Safety, Costs, Quality-of-Life Considerations, and Preferences Lillian Sung ......................................................................................... 570 Genetic Counseling of the Patient with Pediatric Cancer Identification, Management, and Evaluation of Children with Cancer-Predisposition Syndromes Sara Knapke, Kristin Zelley, Kim E. Nichols, Wendy Kohlmann, and Joshua D. Schiffman ......................... 576 How to Manage Very Rare Pediatric Cancers Treating Rare Cancer in Children: The Importance of Evidence Alberto S. Pappo ..................................................................................... 586 Genetic Alterations in Childhood Melanoma Fariba Navid ........................................................................................ 589 Desmoid-Type Fibromatosis in Children: A Step Forward in the Cooperative Group Setting Natalie Pounds and Stephen X. Skapek ................................................................... 593 Molecular Pathways for the Practicing Pediatric Oncologist Targeting the Insulin-Like Growth Factor (IGF) System Is Not as Simple as Just Targeting the Type 1 IGF Receptor Katia Scotlandi and Antonino Belfiore .................................................................... 599 Hedgehog Pathway in Pediatric Cancers: They’re Not Just for Brain Tumors Anymore Tobey J. MacDonald .................................................................................. 605 Pediatric Oncology Educational Session in Honor of Dr. James Nachman Development and Refinement of Augmented Treatment Regimens for Pediatric High-Risk Acute Lymphoblastic Leukemia Stephen P. Hunger. ................................................................................... 611 Refining the Role of Radiation Therapy in Pediatric Hodgkin Lymphoma Melissa M. Hudson and Louis S. Constine. ................................................................ 616 Role of Doxorubicin in Rhabdomyosarcoma: Is the Answer Knowable? Carola A. S. Arndt .................................................................................... 621 Pontine Gliomas in Children: To Biopsy or Not to Biopsy Identification of Novel Biologic Targets in the Treatment of Newly Diagnosed Diffuse Intrinsic Pontine Glioma Nathan J. Robison and Mark W. Kieran .................................................................. 625 Is Biopsy Safe in Children with Newly Diagnosed Diffuse Intrinsic Pontine Glioma? Stephanie Puget, Thomas Blauwblomme, and Jacques Grill. .................................................. 629 Ethics of Biopsy in Children with Newly Diagnosed Diffuse Intrinsic Pontine Glioma Nicholas K. Foreman. ................................................................................. 634 Transition and Decision Making for Palliative Care of Patients with Pediatric Cancer Communication and Decision Support for Children with Advanced Cancer and Their Families Jennifer W. Mack, Chris Feudtner, and Pamela S. Hinds. .................................................... 637
Practice Management and Information Technology Addressing the Imbalance of Supply and Demand: Integrating Advanced Practice Providers into Survivorship Care Planning for the Future: The Role of Nurse Practitioners and Physician Assistants in Survivorship Care Mary S. McCabe and Todd Alan Pickard .............................................................. eArticle Doing It Right, and for Less: Implementing Practice Changes to Manage the Growing Complexities, Inefficiencies, and Costs of Cancer Care Driving Evidence-Based Standardization of Care within a Framework of Personalized Medicine Adam Brufsky, Kathleen Lokay, and Melissa McDonald .................................................. eArticle Patient Portals in Oncology The Future of Oncology Care with Personal Health Records Henry Feldman and Elizabeth S. Rodriguez ............................................................ eArticle The ASCO Quality Oncology Practice Initiative (QOPI) and Beyond Measuring and Improving Value of Care in Oncology Practices: ASCO Programs from Quality Oncology Practice Initiative to the Rapid Learning System Joseph O. Jacobson, Michael N. Neuss, and Robert Hauser ............................................... eArticle Professional Development Physician Wellness: Coping with Repetitive Loss and Work-Related Stress Buoyancy: A Model for Self-Reflection about Stress and Burnout in Oncology Providers Michael J. Fisch .................................................................................. eArticle Encountering Grief in Patient Care Teresa Gilewski. .................................................................................. eArticle Talking in Sync with Patients across Cultural Barriers New Insights in Cross-Cultural Communication Lidia Schapira. ................................................................................... eArticle The Oncologist, the Patient, and the Media Patients with Cancer, Internet Information, and the Clinical Encounter: A Taxonomy of Patient Users Paul R. Helft ..................................................................................... eArticle Sarcoma Global Variations in Access to New Therapies for Sarcomas and Gastrointestinal Stromal Tumor How to Decide Whether to Offer and Use “Nonstandard” Therapies in Patients with Advanced Sarcomas and Gastrointestinal Stromal Tumors: Global Variations in Clinical Practice, Assessment, and Access to Therapies in Diseases with Limited Incidence and Data Stefan Sleijfer, Ian Judson, and George D. Demetri ......................................................... 645 Targeted Therapies in Targeted or Untargeted Sarcomas Targeted Therapy in Sarcoma: Should We Be Lumpers or Splitters? Richard F. Riedel, Robert G. Maki, and Andrew J. Wagner .................................................. 652 What the Busy Oncologist Needs to Know about Gastrointestinal Stromal Tumor Adjuvant Treatment of Gastrointestinal Stromal Tumor: The Proof, the Pro, and the Practice Jaap Verweij ........................................................................................ 659 Management of Tyrosine Kinase Inhibitor–Resistant Gastrointestinal Stromal Tumors Christine M. Barnett and Michael C. Heinrich ............................................................. 663 Tumor Biology Biologic Principles of Targeted Combination Therapy Opportunities and Pitfalls of Targeted Therapeutic Combinations in Solid Tumors Joaquin Mateo, Michael Ong, Timothy A. Yap, and Johann S. de Bono ......................................... 670
Page 1 and 2: AMERICAN SOCIETY OF CLINICAL ONCOLO
Page 3 and 4: American Society of Clinical Oncolo
Page 5 and 6: American Society of Clinical Oncolo
Page 7 and 8: New Looks and Challenges for Cooper
Page 9 and 10: Genitourinary Cancer Best Use of Im
Page 11: Research and Standard of Care: Lung
Page 15 and 16: 2012 ASCO Annual Meeting Disclosure
Page 17 and 18: Matti S. Aapro, MD Clinique De Geno
Page 19 and 20: Hedy Lee Kindler, MD The University
Page 21 and 22: Douglas E. Wood, MD University of W
Page 23 and 24: Mary Lou Smith, JD, MBA Research Ad
Page 25 and 26: ASCO and Conquer Cancer Foundation
Page 27 and 28: Letter from the Editor The theme of
Page 29 and 30: Adjuvant Therapy for Older Women wi
Page 31 and 32: TREATMENT FOR OLDER WOMEN WITH BREA
Page 37 and 38: MANAGEMENT OF T1 BREAST CANCERS the
Page 39 and 40: MANAGEMENT OF T1 BREAST CANCERS Tab
Page 41 and 42: MANAGEMENT OF T1 BREAST CANCERS Tab
Page 43 and 44: MANAGEMENT OF T1 BREAST CANCERS 93.
Page 45 and 46: MANAGEMENT OF T1 BREAST CANCERS 1 c
Page 47 and 48: ADJUVANT ENDOCRINE THERAPY reductio
Page 49 and 50: ADJUVANT ENDOCRINE THERAPY which ra
Page 51 and 52: ADJUVANT ENDOCRINE THERAPY assay is
Page 53 and 54: A DICKENS TALE OF THE TREATMENT OF
Page 55 and 56: TREATMENT OF ADVANCED BREAST CANCER
Page 63 and 64:
TREATMENT OF ADVANCED BREAST CANCER
Page 65 and 66:
A FRESH LOOK AT DUCTAL CARCINOMA IN
Page 67 and 68:
DCIS: OPPORTUNITIES AND UNCHARTED W
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DCIS: OPPORTUNITIES AND UNCHARTED W
Page 71 and 72:
Ductal Carcinoma In Situ, and the I
Page 73 and 74:
DCIS AND INFLUENCE OF RISK FACTORS
Page 75 and 76:
KEY QUESTIONS IN THE LOCO-REGIONAL
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POSTMASTECTOMY RADIATION AND PARTIA
Page 79 and 80:
The Appropriate Extent of Surgery f
Page 81 and 82:
SURGERY FOR EARLY-STAGE BREAST CANC
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BIOLOGY AND LOCAL THERAPY DECISIONS
Page 85 and 86:
Clinical and Imaging Surveillance F
Page 87 and 88:
SURVEILLANCE FOLLOWING BREAST CANCE
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SURVEILLANCE FOLLOWING BREAST CANCE
Page 91 and 92:
Advanced Imaging Techniques for the
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IMAGING TECHNIQUES FOR BREAST CANCE
Page 95 and 96:
IMAGING TECHNIQUES FOR BREAST CANCE
Page 97 and 98:
Update of the Oxford Overview: New
Page 99 and 100:
UPDATE OF THE OXFORD OVERVIEW Fig.
Page 101 and 102:
Page 103 and 104:
Page 105 and 106:
UPDATE OF THE OXFORD OVERVIEW Overv
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Gene Patents and Personalized Medic
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GENE PATENTS AND EFFECTS ON PERSONA
Page 111 and 112:
Chemoprevention for Breast Cancer:
Page 113 and 114:
CHEMOPREVENTION FOR BREAST CANCER T
Page 115 and 116:
CHEMOPREVENTION FOR BREAST CANCER C
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CONTROVERSIES IN PROSTATE CANCER: P
Page 119 and 120:
PROSTATE CANCER RISK REDUCTION men
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PROSTATE CANCER RISK REDUCTION Auth
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PSA SCREENING: HARMS WITHOUT CLEAR
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PSA SCREENING: HARMS WITHOUT CLEAR
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GLIOBLASTOMA: TAKING THE STANDARD O
Page 129 and 130:
GLIOBLASTOMA: BIOLOGY, GENETICS AND
Page 131 and 132:
Page 133 and 134:
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FUTURE DIRECTIONS IN GBM THERAPY pr
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FUTURE DIRECTIONS IN GBM THERAPY Ch
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ESTABLISHING TREATMENTS FOR GLIOBLA
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Page 145 and 146:
Current Concepts in Brain Tumor Ima
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CONCEPTS IN BRAIN TUMOR IMAGING tum
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CONCEPTS IN BRAIN TUMOR IMAGING Aut
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PERSPECTIVES ON HEADLINE-MAKING NEW
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TTF THERAPY IN GLIOBLASTOMA Fig. 1.
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TTF THERAPY IN GLIOBLASTOMA istics.
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TTF THERAPY IN GLIOBLASTOMA because
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Limitations of Adaptive Clinical Tr
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LIMITATIONS OF ADAPTIVE CLINICAL TR
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LIMITATIONS OF ADAPTIVE CLINICAL TR
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Capturing the Patient Perspective:
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PATIENT-REPORTED OUTCOMES AS TRIAL
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PATIENT-REPORTED OUTCOMES AS TRIAL
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NEW LOOKS AND CHALLENGES FOR COOPER
Page 173 and 174:
NCI NATIONAL CLINICAL TRIALS NETWOR
Page 175 and 176:
Successful Integration of Cooperati
Page 177 and 178:
COG: GIVING NEW MEANING TO COOPERAT
Page 179 and 180:
A Critical Review of the Enrollment
Page 181 and 182:
BLACK PATIENTS AND CANCER CLINICAL
Page 183 and 184:
BLACK PATIENTS AND CANCER CLINICAL
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Trastuzumab Emtansine (T-DM1): Hitc
Page 187 and 188:
T-DM1 AND THERAPEUTIC ANTIBODIES ag
Page 189 and 190:
TARGETING CD30 IN HODGKIN LYMPHOMA
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TARGETING CD30 IN HODGKIN LYMPHOMA
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EARLY DRUG DEVELOPMENT: CASTING A W
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Table 1. Response Rates in Expanded
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Drug Development in the Era of Pers
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that the core pathway is not comple
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This situation is not surprising, g
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Practical Management of Immune-Rela
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the anterior pituitary axis is invo
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TARGETING CRITICAL MOLECULAR ABERRA
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Abl suppression; and 3) the early e
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50% 50% 100% Change in Tumor Size m
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vanced solid tumors, even if they a
Page 215 and 216:
Targeting Molecular Aberrations in
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date. With the advent of gene expre
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consortium to facilitate the testin
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ETHICAL CHALLENGES OF HEALTH CARE R
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HEALTH CARE REFORM AND ONCOLOGY dev
Page 225 and 226:
HEALTH CARE REFORM AND ONCOLOGY aut
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INTERNATIONAL VARIATION IN UNDERSTA
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midcareer physician; in one cross-s
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Table 1. Recommendations for Person
Page 233 and 234:
stances (e.g., stage of career, fam
Page 235 and 236:
elationship” is also acknowledged
Page 237 and 238:
Conclusion In more individualistic
Page 239 and 240:
The Oncologist’s Duty to Provide
Page 241 and 242:
an external observer, but to the pe
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MEDICAL ERRORS IN CANCER CARE: PREV
Page 245 and 246:
DISCLOSING MEDICAL ERRORS Disclosur
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DISCLOSING MEDICAL ERRORS Author’
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PREVENTING MEDICAL ERRORS more diff
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“PERSONALIZED” ONCOLOGY FOR COL
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0.001), progression-free survival (
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mately 40% of patients with colorec
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Table 1. Tumor Marker Utility Gradi
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treatment (tx) for metastatic color
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The Interventional Radiologist Role
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effect. The most common drug that h
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gone forever, no further therapy is
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is irrelevant if it is already rese
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Resection and Thermal Ablation of L
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Author’s Disclosures of Potential
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Minimally Invasive Surgery of Recta
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outcomes; local, wound-site, and di
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Authors’ Disclosures of Potential
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CAO/ARO 04 study—which added oxal
Page 281 and 282:
STAGE III COLON CANCER: WHAT WORKS,
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Table 1. Comparison of Fluoropyrimi
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tients with stages II and III color
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ized by high fruit, vegetable, poul
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Exercise Change trial: a randomized
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A New Direction for Pancreatic Canc
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Table 1. FOLFIRINOX versus Gemcitab
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The Southwest Oncology Group (SWOG)
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A Matter of Timing: Is There a Role
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an OS benefit with radiation therap
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a dose of 50.4 Gy to 59.4 Gy of rad
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more commonly given for APC, specia
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subcutaneous bolus or infusion. Hal
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patients are cared for completely w
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Varying Lymphadenectomies for Gastr
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Table 1. Regional Lymph Nodes of th
Page 313 and 314:
Conclusion There are clear differen
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Will Disease Heterogeneity Help Def
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prematurely due to poor accrual. 18
Page 319 and 320:
Adjuvant Treatments for Localized A
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ADJUVANT TREATMENT FOR GASTRIC CANC
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LIVER-DIRECTED THERAPEUTIC OPTIONS
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ated with unique dose distributions
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HCC, with encouraging outcomes in e
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tion. Advanced computer-based image
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a 5-year survival rate of 70% follo
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THE MANAGEMENT OF LESS COMMON BUT C
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Fig 1. PubMed publications and clin
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of therapeutic options, patient sel
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less informative than the GRETCH an
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Table 3. New Agents/Regimens under
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combined with concurrent transarter
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to optimize the use of erlotinib by
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Optimal Use of Imaging to Guide Tre
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enhancement seen. Furthermore, the
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CASTRATION-RESISTANT PROSTATE CANCE
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Fig. 1. FDA regulatory approvals in
Page 355 and 356:
Prognostic, Predictive, and Surroga
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adhesion molecule and further chara
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and treatment options are expanding
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KIDNEY CANCER BIOLOGY AND THERAPEUT
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Prognostic Factors in Advanced RCC
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cell immunotherapy in which a small
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New Developments in Urothelial Canc
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Novel Approaches in Advanced Urothe
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10. Albers P, Park SI, Niegisch G,
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700 at a dose of 400 mg twice daily
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therapy for nonmetastatic prostate
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ADJUVANT THERAPY FOR OLDER PATIENTS
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Adjuvant Systemic Therapy Adjuvant
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with early-stage breast cancer were
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clinical trials to generate additio
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Adjuvant Treatment of Older Patient
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OLDER PATIENTS WITH LUNG CANCER Fig
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OLDER PATIENTS WITH LUNG CANCER adj
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Considerations and Controversies in
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OLDER PATIENTS WITH ADVANCED CANCER
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RECENT CLINICAL HIGHLIGHTS IN GYNEC
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GLOBAL ADVANCES IN GYNECOLOGIC ONCO
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GLOBAL ADVANCES IN GYNECOLOGIC ONCO
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The European Society of Gynaecologi
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ESGO EDUCATIONAL AND RESEARCH ACTIV
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UPFRONT TREATMENT OF OVARIAN CANCER
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ANTIANGIOGENICS AND PARP INHIBITORS
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ANTIANGIOGENICS AND PARP INHIBITORS
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Intraperitoneal Treatment in Ovaria
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INTRAPERITONEAL TREATMENT IN OVARIA
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Dose-Dense Chemotherapy and Neoadju
Page 421 and 422:
CHEMOTHERAPY FOR OVARIAN CANCER Fig
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CHEMOTHERAPY FOR OVARIAN CANCER whi
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UTERINE SARCOMA: CHALLENGING CASES
Page 427 and 428:
HISTOLOGIC FEATURES AND MANAGEMENT
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Page 431 and 432:
Page 433 and 434:
SURGICAL OPTIONS FOR UTERINE SARCOM
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SURGICAL OPTIONS FOR UTERINE SARCOM
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PATIENTS WITH HPV-POSITIVE OROPHARY
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HPV-INDUCED OROPHARYNX CANCER analy
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HPV-INDUCED OROPHARYNX CANCER fract
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Important Early Advances in Squamou
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EARLY ADVANCES IN SCCHN Fig 1. Targ
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Application of Genomic and Proteomi
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GENOMIC AND PROTEOMIC TECHNOLOGIES
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GENOMIC AND PROTEOMIC TECHNOLOGIES
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TREATMENT OF THYROID CANCERS: NEW I
Page 455 and 456:
EVALUATION OF ADVANCED THYROID CANC
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EVALUATION OF ADVANCED THYROID CANC
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Systemic Therapeutic Approaches to
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APPROACHES TO ADVANCED THYROID CANC
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AVOIDING OVERDIAGNOSIS AND OVERTREA
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Table 1. Prevalence of Prostate Can
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Table 3. Potential Risks and Benefi
Page 469 and 470:
Overdiagnosis and Overtreatment of
Page 471 and 472:
een reached by other modeling effor
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east cancer community have FDA-appr
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COSTS OF CANCER CARE: AFFORDABILITY
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REDUCING THE COST OF CANCER CARE Fi
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REDUCING THE COST OF CANCER CARE Th
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REDUCING THE COST OF CANCER CARE de
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Why Hasn’t Genomic Testing Change
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tigators should develop prospective
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MANAGEMENT OF CHRONIC LYMPHOCYTIC L
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PREDICTIVE PARAMETERS IN CLL Table
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PREDICTIVE PARAMETERS IN CLL patien
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Transplant in Chronic Lymphocytic L
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WHEN TO OFFER TRANSPLANTATION IN CL
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WHEN TO OFFER TRANSPLANTATION IN CL
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NEW DEVELOPMENTS IN MYELOPROLIFERAT
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SMALL-MOLECULE INHIBITORS FOR MPN S
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SMALL-MOLECULE INHIBITORS FOR MPN L
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Insights into the Molecular Genetic
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GENETICS OF MYELOPROLIFERATIVE NEOP
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Page 511 and 512:
Page 513 and 514:
Classification of Myeloproliferativ
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CLASSIFICATION AND PROGNOSIS OF MPN
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CLASSIFICATION AND PROGNOSIS OF MPN
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AROUND THE WORLD IN ALMOST 80 MINUT
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LUNG CANCER IN BRAZIL Fig. 1. Relat
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LUNG CANCER IN BRAZIL Fig. 3. Chara
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LUNG CANCER IN BRAZIL Author’s Di
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LUNG CANCER IN CHINA Fig 1. Chinese
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LUNG CANCER IN CHINA well equipped
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Research and Standard of Care: Lung
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LUNG CANCER IN ROMANIA ● Protecti
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LUNG CANCER IN ROMANIA reimbursemen
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A New Model: Physician-Patient Coll
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PHYSICIAN ENGAGEMENT IN ONLINE PATI
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PHYSICIAN ENGAGEMENT IN ONLINE PATI
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LUNG CANCER SCREENING 101 CHAIR Chr
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LUNG CANCER SCREENING The concern i
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LUNG CANCER SCREENING Fig. 1. Guide
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LUNG CANCER SCREENING Fig. 2. Guide
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LUNG CANCER SCREENING 19. Montes RP
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Molecular Testing of Non-Small Cell
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MOLECULAR TESTING AND NSCLC Fig 1.
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MOLECULAR TESTING AND NSCLC logic d
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THYMOMA AND THYMIC CARCINOMA: UPDAT
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MANAGEMENT OF THYMIC CARCINOMA recu
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MANAGEMENT OF THYMIC CARCINOMA Refe
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The Creation of the International T
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ITMIG AS A MODEL FOR RARE DISEASES
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Thymoma: From Chemotherapy to Targe
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SYSTEMIC TREATMENT OF THYMOMA Study
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SYSTEMIC TREATMENT OF THYMOMA cance
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What Is the Best Strategy for Incor
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TREATMENT OF FOLLICULAR LYMPHOMA Fi
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TREATMENT OF FOLLICULAR LYMPHOMA me
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TREATMENT OF FOLLICULAR LYMPHOMA ou
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TREATMENT OPTIONS IN INDOLENT LYMPH
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Page 587 and 588:
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ROLE OF HCT FOR INDOLENT LYMPHOMA T
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ROLE OF HCT FOR INDOLENT LYMPHOMA T
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ROLE OF HCT FOR INDOLENT LYMPHOMA e
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CONTROVERSIES IN MYELOMA: INDUCTION
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TRANSPLANTATION FOR MYELOMA Alterna
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TRANSPLANTATION FOR MYELOMA compare
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TRANSPLANTATION FOR MYELOMA autolog
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CURRENT STATUS OF MYELOMA THERAPY K
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CURRENT STATUS OF MYELOMA THERAPY F
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CURRENT STATUS OF MYELOMA THERAPY T
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Maintenance Therapy for Myeloma: Ho
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MAINTENANCE THERAPY FOR MULTIPLE MY
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NEW OPTIONS, NEW QUESTIONS: HOW TO
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THERAPIES FOR PATIENTS WITH METASTA
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ANTIEMETICS: CURRENT STANDARDS, EME
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ANTIEMETICS: ASCO GUIDELINE UPDATE
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Chemotherapy-Induced Nausea and Vom
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INCIDENCE AND PREVALENCE OF CHEMOTH
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New Frontiers in Mucositis By Dougl
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MUCOSAL INJURY CAUSED BY CANCER THE
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Short- and Long-term Cardiovascular
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Recent Advances in Cardiotoxicity o
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CARDIOTOXICITY OF ANTICANCER THERAP
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CARDIOTOXICITY OF ANTICANCER THERAP
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The Oncologist as the Patient with
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THE ONCOLOGIST AS THE PATIENT OR RE
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Prolonged Febrile Neutropenia in th
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FEBRILE NEUTROPENIA IN PEDIATRIC CA
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FEBRILE NEUTROPENIA IN PEDIATRIC CA
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TREATMENT APPROACHES IN CHILDREN wh
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TREATMENT APPROACHES IN CHILDREN th
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GENETIC COUNSELING OF THE PATIENT W
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CANCER PREDISPOSITION IN CHILDHOOD
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HOW TO MANAGE VERY RARE PEDIATRIC C
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RARE CANCER IN CHILDREN Registries
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Genetic Alterations in Childhood Me
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GENETIC ALTERATIONS IN CHILDHOOD ME
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Desmoid-Type Fibromatosis in Childr
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CHEMOTHERAPY FOR DESMOID TUMOR Tabl
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CHEMOTHERAPY FOR DESMOID TUMOR 14.
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Targeting the Insulin-Like Growth F
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TARGETING THE IGF SYSTEM Fig. 1. Th
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TARGETING THE IGF SYSTEM malignanci
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Hedgehog Pathway in Pediatric Cance
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HEDGEHOG PATHWAY IN PEDIATRIC CANCE
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HEDGEHOG PATHWAY IN PEDIATRIC CANCE
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Development and Refinement of Augme
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ABFM THERAPY FOR PEDIATRIC ALL than
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ABFM THERAPY FOR PEDIATRIC ALL Auth
Page 711 and 712:
RADIOTHERAPY FOR PEDIATRIC HODGKIN
Page 713 and 714:
RADIOTHERAPY FOR PEDIATRIC HODGKIN
Page 715 and 716:
Role of Doxorubicin in Rhabdomyosar
Page 717 and 718:
DOXORUBICIN IN RHABDOMYOSARCOMA 8.
Page 719 and 720:
Identification of Novel Biologic Ta
Page 721 and 722:
NOVEL TARGETS IN THE TREATMENT OF D
Page 723 and 724:
Is Biopsy Safe in Children with New
Page 725 and 726:
SAFETY OF DIPG BIOPSY IN CHILDREN F
Page 727 and 728:
SAFETY OF DIPG BIOPSY IN CHILDREN 1
Page 729 and 730:
CHILDREN WITH DIFFUSE INTRINSIC PON
Page 731 and 732:
Communication and Decision Support
Page 733 and 734:
COMMUNICATION AND DECISION SUPPORT
Page 735 and 736:
Page 737 and 738:
Page 739 and 740:
Planning for the Future: The Role o
Page 741 and 742:
present in the office suite but doe
Page 743 and 744:
Summary and Care Plan are provided.
Page 745 and 746:
DOING IT RIGHT, AND FOR LESS: IMPLE
Page 747 and 748:
CLINICAL PATHWAYS STANDARDIZING PER
Page 749 and 750:
CLINICAL PATHWAYS STANDARDIZING PER
Page 751 and 752:
The Future of Oncology Care with Pe
Page 753 and 754:
quantity. Determining the appropria
Page 755 and 756:
THE ASCO QUALITY ONCOLOGY PRACTICE
Page 757 and 758:
IMPROVING VALUE OF CARE IN ONCOLOGY
Page 759 and 760:
Page 761 and 762:
Page 763 and 764:
PHYSICIAN WELLNESS: COPING WITH REP
Page 765 and 766:
also provides insight on how clinic
Page 767 and 768:
good resource for exploring the pri
Page 769 and 770:
of death or following death and inc
Page 771 and 772:
telephone call to the family, sendi
Page 773 and 774:
New Insights in Cross-Cultural Comm
Page 775 and 776:
CROSS-CULTURAL COMMUNICATION Sideba
Page 777 and 778:
THE ONCOLOGIST, THE PATIENT, AND TH
Page 779 and 780:
estimate of the proportion of their
Page 781 and 782:
exactly the same treatment, even th
Page 783 and 784:
How to Decide Whether to Offer and
Page 785 and 786:
NONSTANDARD THERAPIES FOR ADVANCED
Page 787 and 788:
NONSTANDARD THERAPIES FOR ADVANCED
Page 789 and 790:
TARGETED THERAPIES IN TARGETED OR U
Page 791 and 792:
TARGETED THERAPY IN SARCOMA rates a
Page 793 and 794:
TARGETED THERAPY IN SARCOMA seen in
Page 795 and 796:
TARGETED THERAPY IN SARCOMA recepto
Page 797 and 798:
Adjuvant Treatment of Gastrointesti
Page 799 and 800:
ADJUVANT THERAPY IN HIGH-RISK GASTR
Page 801 and 802:
Management of Tyrosine Kinase Inhib
Page 803 and 804:
TKI-RESISTANT GIST Primary Imatinib
Page 805 and 806:
TKI-RESISTANT GIST Table 2. Clinica
Page 807 and 808:
BIOLOGIC PRINCIPLES OF TARGETED COM
Page 809 and 810:
COMBINING TARGETED AGENTS IN CLINIC
Page 811 and 812:
COMBINING TARGETED AGENTS IN CLINIC
Page 813 and 814:
Combination Therapies Building on t
Page 815 and 816:
COMBINATIONS FOR MELANOMA agents th
Page 817 and 818:
MECHANISMS OF RESISTANCE TO TARGETE
Page 819 and 820:
RESISTANCE MECHANISMS TO MAPK INHIB
Page 821 and 822:
RESISTANCE MECHANISMS TO MAPK INHIB
Page 823 and 824:
Mechanisms of Resistance to Targete
Page 825 and 826:
RESISTANCE TO TARGETED THERAPIES IN
Page 827 and 828:
RESISTANCE TO TARGETED THERAPIES IN
Page 829 and 830:
Translating PI3K-Delta Inhibitors t
Page 831 and 832:
THE STORY OF CAL-101 6% of patients
Page 833 and 834:
PI3 Kinase in Cancer: From Biology
Page 835 and 836:
PI3 KINASE IN CANCER Fig. 1. The PI
Page 837 and 838:
PI3 KINASE IN CANCER Fig. 3. In viv
Page 840:
This publication is supported by an
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2012 EDUCATIONAL BOOK - American Society of Clinical Oncology

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