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2012 EDUCATIONAL BOOK - American Society of Clinical Oncology

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partial or incomplete response. 43,44 Whether modifying<br />

treatment for patients with disease that does not achieved<br />

complete metabolic response will improve outcomes has yet<br />

to be determined. Finally, the emergence <strong>of</strong> new biologic<br />

Authors’ Disclosures <strong>of</strong> Potential Conflicts <strong>of</strong> Interest<br />

Author<br />

Employment or<br />

Leadership<br />

Positions<br />

Consultant or<br />

Advisory Role<br />

Gilles Salles Calistoga<br />

Pharmaceuticals;<br />

Celgene;<br />

Janssen-Cilag;<br />

Roche<br />

Hervé Ghesquières*<br />

Emmanuel Bachy*<br />

*No relevant relationships to disclose.<br />

1. Pulte D, Gondos A, Brenner H. Expected long-term survival <strong>of</strong> older<br />

patients diagnosed with non-Hodgkin lymphoma in 2008-<strong>2012</strong>. Cancer Epidemiol.<br />

<strong>2012</strong>;36:e19-25.<br />

2. Fisher RI, LeBlanc M, Press OW, et al. New treatment options have<br />

changed the survival <strong>of</strong> patients with follicular lymphoma. J Clin Oncol.<br />

2005;23:8447-8452.<br />

3. Sebban C, Brice P, Delarue R, et al. Impact <strong>of</strong> rituximab and/or<br />

high-dose therapy with autotransplant at time <strong>of</strong> relapse in patients with<br />

follicular lymphoma: A GELA study. J Clin Oncol. 2008;26:3614-3620.<br />

4. Friedberg JW, Taylor MD, Cerhan JR, et al. Follicular lymphoma in the<br />

United States: first report <strong>of</strong> the national LymphoCare study. J Clin Oncol.<br />

2009;27:1202-1208.<br />

5. Bertoni F, Coiffier B, Salles G, et al. MALT lymphomas: pathogenesis<br />

can drive treatment. <strong>Oncology</strong>. 2011;25:1134-1142, 1147.<br />

6. Peinert S, Seymour JF. Indolent lymphomas other than follicular and<br />

marginal zone lymphomas. Hematol Oncol Clin North Am. 2008;22:903-940.<br />

7. Vaughan Hudson B, Vaughan Hudson G, MacLennan KA, et al. <strong>Clinical</strong><br />

stage 1 non-Hodgkin’s lymphoma: long-term follow-up <strong>of</strong> patients treated by<br />

the British National Lymphoma Investigation with radiotherapy alone as<br />

initial therapy. Br J Cancer. 1994;69:1088-1093.<br />

8. Mac Manus MP, Hoppe RT. Is radiotherapy curative for stage I and II<br />

low-grade follicular lymphoma? Results <strong>of</strong> a long-term follow-up study <strong>of</strong><br />

patients treated at Stanford University. J Clin Oncol. 1996;14:1282-1290.<br />

9. Advani R, Rosenberg SA, Horning SJ. Stage I and II follicular non-<br />

Hodgkin’s lymphoma: long-term follow-up <strong>of</strong> no initial therapy. J Clin Oncol.<br />

2004;22:1454-1459.<br />

10. Pugh TJ, Ballon<strong>of</strong>f A, Newman F, et al. Improved survival in patients<br />

with early stage low-grade follicular lymphoma treated with radiation: a<br />

Surveillance, Epidemiology, and End Results database analysis. Cancer.<br />

2010;116:3843-3851.<br />

11. Friedberg J, Byrtek M, Link B, et al. Should radiation therapy (Xrt) be<br />

the standard therapeutic approach for stage I follicular lymphoma (FL)? A<br />

comparative effectiveness analysis <strong>of</strong> the National Lymphocare Study (Nlcs).<br />

In: Internationational Conference on Malignat Lymphoma; 2011; Lugano;<br />

2011;p. iv91.<br />

12. Dreyling M, Ghielmini M, Marcus R, et al. Newly diagnosed and<br />

relapsed follicular lymphoma: ESMO <strong>Clinical</strong> Practice Guidelines for diagnosis,<br />

treatment and follow-up. Ann Oncol. 2011;22:vi59-63 (suppl 6).<br />

13. Zelenetz AD, Abramson JS, Advani RH, et al. NCCN <strong>Clinical</strong> Practice<br />

Guidelines in <strong>Oncology</strong>: Non-Hodgkin’s lymphomas. JNCCN. 2010;8:288-334.<br />

14. Lowry L, Smith P, Qian W, et al. Reduced dose radiotherapy for local<br />

control in non-Hodgkin lymphoma: a randomised phase III trial. Radiother<br />

Oncol. 2011;100:86-92.<br />

15. Young RC, Longo DL, Glatstein E, et al. The treatment <strong>of</strong> indolent<br />

lymphomas: watchful waiting v aggressive combined modality treatment.<br />

Semin Hematol. 1988;25:11-16 (suppl 2).<br />

16. Brice P, Bastion Y, Lepage E, et al. Comparison in low-tumor-burden<br />

follicular lymphomas between an initial no-treatment policy, prednimustine,<br />

or interferon alfa: a randomized study from the Groupe d’Etude des Lymphomes<br />

Folliculaires. Groupe d’Etude des Lymphomes de l’Adulte. J Clin<br />

Oncol. 1997;15:1110-1117.<br />

17. Ardeshna KM, Smith P, Norton A, al. E. Long-term effect <strong>of</strong> a watch<br />

and wait policy versus immediate systemic treatment for asymptomatic<br />

492<br />

therapies, such engineered monoclonal antibodies, 45 immunomodulatory<br />

agents, 46 or kinase inhibitors, 47 represent<br />

innovative options that might change the current treatment<br />

landscape.<br />

Stock<br />

Ownership Honoraria<br />

REFERENCES<br />

Celgene;<br />

Janssen-Cilag;<br />

Pfizer; Roche<br />

Research<br />

Funding<br />

SALLES, GHESQUIÈRES, AND BACHY<br />

Expert<br />

Testimony<br />

Other<br />

Remuneration<br />

advanced-stage non-Hodgkin lymphoma: a randomised controlled trial. Lancet.<br />

2003;362:516-522.<br />

18. Hainsworth JD, Burris HA, 3rd, Morrissey LH, et al. Rituximab<br />

monoclonal antibody as initial systemic therapy for patients with low-grade<br />

non-Hodgkin lymphoma. Blood. 2000;95:3052-3056.<br />

19. Colombat P, Salles G, Brousse N, et al. Rituximab (anti-CD20 monoclonal<br />

antibody) as single first-line therapy for patients with follicular<br />

lymphoma with a low tumor burden: clinical and molecular evaluation. Blood.<br />

2001;97:101-106.<br />

20. Ghielmini M, Schmitz SF, Cogliatti S, et al. Effect <strong>of</strong> single-agent<br />

rituximab given at the standard schedule or as prolonged treatment in<br />

patients with mantle cell lymphoma: a study <strong>of</strong> the Swiss Group for <strong>Clinical</strong><br />

Cancer Res (SAKK). J Clin Oncol. 2005;23:705-711.<br />

21. Martinelli G, Schmitz SF, Utiger U, et al. Long-term follow-up <strong>of</strong><br />

patients with follicular lymphoma receiving single-agent rituximab at two<br />

different schedules in trial SAKK 35/98. J Clin Oncol. 2010;28:4480-4484.<br />

22. Ardeshna KM, Smith P, Qian W, et al. An intergroup randomised trial<br />

<strong>of</strong> rituximab versus a watch and wait strategy in patients with stage II, III,<br />

IV, asymptomatic, non-bulky follicular lymphoma (grades 1, 2 and 3a). A<br />

preliminary analysis. ASH Annual Meeting Abstracts. 2011;116 (abstr 6).<br />

23. Ardeshna KM, Qian W, Stephens R, et al. Preliminary Results Of<br />

Quality Of Life (Qol) Analyses From The Intergroup Phase III Randomised<br />

Trial Of Rituximab Vs A Watch And Wait Approach In Patients With<br />

Advanced Stage, Asymptomatic, Non-Bulky Follicular Lymphoma (FL). Ann<br />

Oncol. 2011;22:iv88 (suppl 4).<br />

24. Kahl BS, Hong F, Williams ME, et al. Results <strong>of</strong> Eastern Cooperative<br />

<strong>Oncology</strong> Group Protocol E4402 (RESORT): a randomized phase III study<br />

comparing two different rituximab dosing strategies for low tumor burden<br />

follicular lymphoma. ASH Annual Meeting Abstracts. 2011:118 (suppl LBA-<br />

6).<br />

25. Leonard JP, Coleman M, Kostakoglu L, et al. Abbreviated chemotherapy<br />

with fludarabine followed by tositumomab and iodine I 131 tositumomab<br />

for untreated follicular lymphoma. J Clin Oncol. 2005;23:5696-5704.<br />

26. Zinzani PL, Tani M, Pulsoni A, et al. Fludarabine and mitoxantrone<br />

followed by yttrium-90 ibritumomab tiuxetan in previously untreated patients<br />

with follicular non-Hodgkin lymphoma trial: a phase II nonrandomised<br />

trial (FLUMIZ). Lancet Oncol. 2008;9:352-358.<br />

27. Link BK, Martin P, Kaminski MS, et al. Cyclophosphamide, vincristine,<br />

and prednisone followed by tositumomab and iodine-131-tositumomab in<br />

patients with untreated low-grade follicular lymphoma: eight-year follow-up<br />

<strong>of</strong> a multicenter phase II study. J Clin Oncol. 2010;28:3035-3041.<br />

28. Marcus R, Imrie K, Solal-Celigny P, et al. Phase III study <strong>of</strong> R-CVP<br />

compared with cyclophosphamide, vincristine, and prednisone alone in patients<br />

with previously untreated advanced follicular lymphoma. J Clin Oncol.<br />

2008;26:4579-4586.<br />

29. Salles G, Seymour JF, Offner F, et al. Rituximab maintenance for 2<br />

years in patients with high tumour burden follicular lymphoma responding to<br />

rituximab plus chemotherapy (PRIMA): a phase 3, randomised controlled<br />

trial. Lancet. 2011;377:42-51.<br />

30. Federico M, Luminari S, Dondi A, et al. R-CVP vs R-CHOP vs R-FM for<br />

the initial treatment <strong>of</strong> patients with advanced stage follicular lymphoma.<br />

Preliminary results <strong>of</strong> Foll05 Iil Trial. Ann Oncol. 2011;22:iv128 (suppl 4).<br />

31. Nastoupil L, Sinha R, Byrtek M, et al. A comparison <strong>of</strong> the effectiveness

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