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2012 EDUCATIONAL BOOK - American Society of Clinical Oncology

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GLIOBLASTOMA: BIOLOGY, GENETICS AND BEHAVIOR<br />

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using mathematical modeling to quantify glioma growth and invasion. J Neurol<br />

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4. Bellail AC, Hunter SB, Brat DJ, et al. Microregional extracellular matrix<br />

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5. Gupta M, Djalilvand A, Brat DJ. Clarifying the diffuse gliomas: an<br />

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9. Moskowitz SI, Jin T, Prayson RA. Role <strong>of</strong> MIB1 in predicting survival in<br />

patients with glioblastomas. J Neurooncol. 2006;76:193-200.<br />

10. Brat DJ, Van Meir EG. Vaso-occlusive and prothrombotic mechanisms<br />

associated with tumor hypoxia, necrosis, and accelerated growth in glioblastoma.<br />

Lab Invest. 2004;84:397-405.<br />

11. Rong Y, Durden DL, Van Meir EG, et al. “Pseudopalisading” necrosis in<br />

glioblastoma: a familiar morphologic feature that links vascular pathology,<br />

hypoxia, and angiogenesis. J Neuropathol Exp Neurol. 2006;65:529-539.<br />

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glioblastoma are hypoxic, express extracellular matrix proteases, and are<br />

formed by an actively migrating cell population. Cancer Res. 2004;64:920-927.<br />

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central nervous system malignancies: a potential role in astrocytoma progression<br />

to glioblastoma. Brain Pathol. 2008;18:164-171.<br />

16. Senger DR, Galli SJ, Dvorak AM, et al. Tumor cells secrete a vascular<br />

permeability factor that promotes accumulation <strong>of</strong> ascites fluid. Science.<br />

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human glioblastoma multiforme. Science. 2008;321:1807-1812.<br />

27. Yan H, Parsons DW, Jin G, et al. IDH1 and IDH2 mutations in gliomas.<br />

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