18.12.2012 Views

2012 EDUCATIONAL BOOK - American Society of Clinical Oncology

2012 EDUCATIONAL BOOK - American Society of Clinical Oncology

2012 EDUCATIONAL BOOK - American Society of Clinical Oncology

SHOW MORE
SHOW LESS

Create successful ePaper yourself

Turn your PDF publications into a flip-book with our unique Google optimized e-Paper software.

Authors’ Disclosures <strong>of</strong> Potential Conflicts <strong>of</strong> Interest<br />

Author<br />

Employment or<br />

Leadership<br />

Positions<br />

Consultant or<br />

Advisory Role<br />

Stock<br />

Ownership Honoraria<br />

Richard F. Riedel Merck ARIAD; Novartis;<br />

Pfizer<br />

Robert G. Maki Bayer; Eisai;<br />

Lilly; Novartis<br />

Andrew J. Wagner Astex<br />

Therapeutics (U);<br />

EMD Serono;<br />

Genentech;<br />

Infinity;<br />

Morphotek;<br />

Novartis; Pfizer;<br />

San<strong>of</strong>i<br />

1. Jemal A, Siegel R, Xu J, et al. Cancer statistics, 2010. CA Cancer J Clin.<br />

2010;60:277-300.<br />

2. Baird K, Davis S, Antonescu CR, et al. Gene expression pr<strong>of</strong>iling <strong>of</strong><br />

human sarcomas: insights into sarcoma biology. Cancer Res. 2005;65:9226-<br />

9235.<br />

3. Chawla SP, Staddon AP, Baker LH, et al. Phase II study <strong>of</strong> the<br />

mammalian target <strong>of</strong> rapamycin inhibitor ridaforolimus in patients with<br />

advanced bone and s<strong>of</strong>t tissue sarcomas. J Clin Oncol. <strong>2012</strong>;30:78-84.<br />

4. Chawla SP, Blay J, Ray-Coquard IL, et al. Results <strong>of</strong> the phase III,<br />

placebo-controlled trial (SUCCEED) evaluating the mTOR inhibitor ridaforolimus<br />

(R) as maintenance therapy in advanced sarcoma patients (pts)<br />

following clinical benefit from prior standard cytotoxic chemotherapy (CT).<br />

J Clin Oncol. 2011;29(suppl; abstr 10005).<br />

5. Demetri GD, Chawla SP, Ray-Coquard I, et al. Exploratory analysis <strong>of</strong><br />

potential predictive markers to identify sensitive/responder sarcoma patients<br />

with ridaforolimus in the phase 3 randomized placebo-controlled trial (SUC-<br />

CEED). Poster presented at: Combined Meeting <strong>of</strong> the Connective Tissue<br />

<strong>Oncology</strong> <strong>Society</strong>/Musculoskeletal Tumor <strong>Society</strong>; October 2011; Chicago, IL.<br />

6. D’Adamo DR, Anderson SE, Albritton K, et al. Phase II study <strong>of</strong><br />

doxorubicin and bevacizumab for patients with metastatic s<strong>of</strong>t-tissue sarcomas.<br />

J Clin Oncol. 2005;23:7135-7142.<br />

7. Verschraegen CF, Arias-Pulido H, Lee SJ, et al. Phase IB study <strong>of</strong> the<br />

combination <strong>of</strong> docetaxel, gemcitabine, and bevacizumab in patients with<br />

advanced or recurrent s<strong>of</strong>t tissue sarcoma: the Axtell regimen. Ann Oncol.<br />

Epub 2011 Jul 11.<br />

8. Agulnik M, Okuno SH, Von Mehren M, et al. An open-label multicenter<br />

phase II study <strong>of</strong> bevacizumab for the treatment <strong>of</strong> angiosarcoma. J Clin<br />

Oncol. 2009;27:XXX (suppl; abstr 10522).<br />

9. Maki RG, D’Adamo DR, Keohan ML, et al. Phase II study <strong>of</strong> sorafenib in<br />

patients with metastatic or recurrent sarcomas. J Clin Oncol. 2009;27:3133-<br />

3140.<br />

10. George S, Merriam P, Maki RG, et al. Multicenter phase II trial <strong>of</strong><br />

sunitinib in the treatment <strong>of</strong> nongastrointestinal stromal tumor sarcomas.<br />

J Clin Oncol. 2009;27:3154-3160.<br />

11. Sleijfer S, Ray-Coquard I, Papai Z, et al. Pazopanib, a multikinase<br />

angiogenesis inhibitor, in patients with relapsed or refractory advanced s<strong>of</strong>t<br />

tissue sarcoma: a phase II study from the European organisation for research<br />

and treatment <strong>of</strong> cancer-s<strong>of</strong>t tissue and bone sarcoma group (EORTC study<br />

62043). J Clin Oncol. 2009;27:3126-3132.<br />

12. Grignani G, Palmerini E, Dileo P, et al. A phase II trial <strong>of</strong> sorafenib in<br />

relapsed and unresectable high-grade osteosarcoma after failure <strong>of</strong> standard<br />

multimodal therapy: an Italian Sarcoma Group study. Ann Oncol. <strong>2012</strong>;23:<br />

508-516.<br />

13. Van Der Graaf WT, Blay J, Chawla SP, et al. PALETTE: a randomized,<br />

double-blind, phase III trial <strong>of</strong> pazopanib versus placebo in patients with<br />

s<strong>of</strong>t-tissue sarcoma whose disease has progressed during or following prior<br />

chemotherapy—an EORTC STBSG Global Network Study (EORTC 62072).<br />

J Clin Oncol. 2011;29 (suppl; abstr LBA002).<br />

14. Gardner K, Judson I, Leahy M, et al. Activity <strong>of</strong> cediranib, a highly<br />

potent and selective VEGF signaling inhibitor, in alveolar s<strong>of</strong>t part sarcoma.<br />

J Clin Oncol. 2009;27:15s (suppl; abstr 10523)<br />

15. Stacchiotti S, Negri T, Zaffaroni N, et al. Sunitinib in advanced alveolar<br />

s<strong>of</strong>t part sarcoma; evidence <strong>of</strong> a direct antitumor effect. Ann Oncol. 2011;22:<br />

1682-1690.<br />

16. Stacchiotti S, Negri T, Palassini E, et al. Sunitinib malate and figitu-<br />

656<br />

REFERENCES<br />

Novartis;<br />

Ziopharm<br />

<strong>Oncology</strong><br />

Research<br />

Funding<br />

ARIAD; Novartis;<br />

Ziopharm<br />

<strong>Oncology</strong><br />

Pfizer; Roche<br />

ArQule;<br />

Genentech;<br />

Prolexys<br />

RIEDEL, MAKI, AND WAGNER<br />

Expert<br />

Testimony<br />

Other<br />

Remuneration<br />

mumab in solitary fibrous tumor; patterns and molecular bases <strong>of</strong> tumor<br />

response. Mol Cancer Ther. 2010;9:1286-1297.<br />

17. Park MS, Patel SR, Ludwig JA, et al. Activity <strong>of</strong> temozolomide and<br />

bevacizumab in the treatment <strong>of</strong> locally advanced, recurrent, and metastatic<br />

hemangiopericytoma and malignant solitary fibrous tumor. Cancer. 2011;117:<br />

4939-4947.<br />

18. Miriuka SG, Rao V, Peterson M, et al. mTOR inhibition induces<br />

endothelial progenitor cell death. Am J Transplant. 2006;6:2069-2079.<br />

19. Dancey JE, Monzon J. Ridaforolimus: a promising drug in the treatment<br />

<strong>of</strong> s<strong>of</strong>t-tissue sarcoma and other malignancies. Future Oncol. 2011;7:<br />

827-839.<br />

20. Baker LH, Rowinsky EK, Mendelson D, et al. Randomized, phase II<br />

study <strong>of</strong> the thrombospondin-1-mimetic angiogenesis inhibitor ABT-510 in<br />

patients with advanced s<strong>of</strong>t tissue sarcoma. J Clin Oncol. 2008;26:5583-5588.<br />

21. Dowlati A, Robertson K, Cooney M, et al. A phase I pharmacokinetic<br />

and translational study <strong>of</strong> the novel vascular targeting agent combretastatin<br />

a-4 phosphate on a single-dose intravenous schedule in patients with advanced<br />

cancer. Cancer Res. 2002;62:3408-3416.<br />

22. Bilenker JH, Flaherty KT, Rosen M, et al. Phase I trial <strong>of</strong> combretastatin<br />

a-4 phosphate with carboplatin. Clin Cancer Res. 2005;11:1527-1533.<br />

23. van Valen F, Winkelmann W, Jurgens H. Type I and type II insulin-like<br />

growth factor receptors and their function in human Ewing’s sarcoma cells. J<br />

Cancer Res Clin Oncol. 1992;118:269-275.<br />

24. Tolcher AW, Sarantopoulos J, Patnaik A, et al. Phase I, pharmacokinetic,<br />

and pharmacodynamic study <strong>of</strong> AMG 479, a fully human monoclonal<br />

antibody to insulin-like growth factor receptor 1. J Clin Oncol. 2009;27:5800-<br />

5807.<br />

25. Olmos D, Postel-Vinay S, Molife LR, et al. Safety, pharmacokinetics,<br />

and preliminary activity <strong>of</strong> the anti-IGF-1R antibody figitumumab (CP-<br />

751,871) in patients with sarcoma and Ewing’s sarcoma: a phase 1 expansion<br />

cohort study. Lancet Oncol. 2010;11:129-135.<br />

26. Malempati S, Weigel B, Ingle AM, et al. Phase I/II trial and pharmacokinetic<br />

study <strong>of</strong> cixutumumab in pediatric patients with refractory solid<br />

tumors and Ewing sarcoma: a report from the Children’s <strong>Oncology</strong> Group.<br />

J Clin Oncol. <strong>2012</strong>;30:256-262.<br />

27. Juergens H, Daw NC, Geoerger B, et al. Preliminary efficacy <strong>of</strong><br />

the anti-insulin-like growth factor type 1 receptor antibody figitumumab<br />

in patients with refractory Ewing sarcoma. J Clin Oncol. 2011;29:4534-<br />

4540.<br />

28. Pappo AS, Patel SR, Crowley J, et al. R1507, a monoclonal antibody to<br />

the insulin-like growth factor 1 receptor, in patients with recurrent or refractory<br />

Ewing sarcoma family <strong>of</strong> tumors: Results <strong>of</strong> a phase II Sarcoma Alliance for<br />

Research through Collaboration study. J Clin Oncol. 2011;29:4541-4547.<br />

29. Huang F, Greer A, Hurlburt W, et al. The mechanisms <strong>of</strong> differential<br />

sensitivity to an insulin-like growth factor-1 receptor inhibitor (BMS-536924)<br />

and rationale for combining with EGFR/HER2 inhibitors. Cancer Res. 2009;<br />

69:161-170.<br />

30. Potratz JC, Saunders DN, Wai DH, et al. Synthetic lethality screens<br />

reveal RPS6 and MST1R as modifiers <strong>of</strong> insulin-like growth factor-1 receptor<br />

inhibitor activity in childhood sarcomas. Cancer Res. 2010;70:8770-8781.<br />

31. Nahta R, Yuan LX, Zhang B, et al. Insulin-like growth factor-I receptor/<br />

human epidermal growth factor receptor 2 heterodimerization contributes to<br />

trastuzumab resistance <strong>of</strong> breast cancer cells. Cancer Res. 2005;65:11118-<br />

11128.<br />

32. Del Valle L, Wang JY, Lassak A, et al. Insulin-like growth factor I

Hooray! Your file is uploaded and ready to be published.

Saved successfully!

Ooh no, something went wrong!