2012 EDUCATIONAL BOOK - American Society of Clinical Oncology

More documents

Recommendations

Info

THERAPEUTIC OPTIONS FOR PANCREATIC NETS for 7 days, every other week, and thalidomide at doses of 50 to 400 mg daily; this combination was associated with objective tumor responses in 5 of 11 patients (45%). 15 A subsequent phase II study evaluated the combination of temozolomide and bevacizumab in the treatment of 34 patients with NETs (15 pancreatic, 19 carcinoid). 16 Patients received 150 mg/m 2 /day of temozolomide orally for 7 days, every other week, and 5 mg/kg of bevacizumab intravaneously every other week. Because of anticipated lymphopenia, patients also received prophylaxis with trimethoprim/ sulfamethoxazole (1 double strength tablet every Monday, Wednesday, Friday). Objective tumor responses were observed in 33% of patients with pancreatic NETs, but not in patients with carcinoid tumors. In a third, prospective study, a regimen of everolimus and temozolomide was associated with an overall tumor RR of 35% for patients with advanced pancreatic NETs. 17 Taken together, these prospective and retrospective studies suggest that temozolomidebased therapy is comparable to streptozocin-based regimens and might reasonably be associated with an overall tumor RR of 30% to 40% for patients with advanced pancreatic NETs. Interestingly, preclinical and early clinical evidence suggests that capecitabine may be synergistic with temozolomide. 18,19 In a series of 17 patients with pancreatic NETs, combination therapy with temozolomide and capecitabine was associated with a tumor RR of 59%. 20 A recent singleinstitution retrospective study by Strosberg and colleagues reported RRs of 70% and median PFS of 18 months for 30 patients with advanced pancreatic NETs. 21 In this study, temozolomide was administered at a dose of 200 mg/m 2 on days 10 to 14, and capecitabine was administered at a dose of 750 mg/m 2 twice daily on days 1 to 14. The combination and specific dosing schedules were well-tolerated, with only four patients experiencing grade 3 or 4 adverse events (anemia, thrombocytopenia, elevated aspartate aminotransferase, and elevated alanine aminotranferease). The most common grade 1 and 2 adverse events were fatigue, nausea, myelosuppression, and hand-foot syndrome. Based on this study, the combination of temozolomide and capecitabine has become popular and commonly used in patients with advanced pancreatic NETs. Other Therapies for Advanced Disease Hepatic metastases commonly occur in patients with pancreatic NETs and adversely affect overall prognosis and quality of life. Therapies directed at locoregional control of hepatic disease may be necessary to decrease symptoms associated with hormone excess. Surgery for hepatic metastases should be considered whenever the metastases are considered resectable and when there is no evidence of extrahepatic disease. Thermal ablation or cryoablation may be considered as an adjunct to surgery or in settings where extrahepatic disease or comorbidities might favor a less aggressive intervention. Selective catheterization of the hepatic artery and embolization of vessels perfusing the tumors can result in clinically significant responses. Embolization options include bland embolization, chemoembolization, and radioembolization. Retrospective studies report benefit, though no prospective studies have been conducted. 22 Radiolabeled somatostatin analogs with therapeutic doses of the radioactive isotope can also provide disease control in patients with advanced disease and are used routinely in Europe. 23 The most commonly used radionuclides are indium ( 111 I), yttrium ( 90 Y), and lutetium ( 177 Lu) and are only available in Europe. The largest retrospective study of patients with gastroenteropancreatic NETs demonstrated clinical responses in 46% of patients at 3 months (complete 2%, partial 28%, and minor 16%) and stable disease in 36%; the minority had progressive disease (20%). Median time to progression (TTP) was 40 months; median OS was 128 months. The bone marrow and kidneys are the most important dose-limiting organs in peptide receptor radionuclide therapy. 24 Prospective randomized studies are needed to confirm these observed benefits. Ongoing and Future Directions The renaissance of clinical research in the field of NETs has only just begun. Ongoing and proposed studies are poised to answer important questions. First, do somatostatin analogs have antitumor activity in pancreatic NETs? Though many physicians extrapolate the findings from the PROMID study, 25 there is currently no prospective data to support the use of somatostatin analogs as antitumor agents for pancreatic NETs. An ongoing international study was designed to answer this question by randomly selecting patients with advanced nonfunctioning pancreatic NETs to receive lanreotide autogel versus placebo (CLARINET, NCT00353496). Primary endpoints are TTP and death. The study opened in June 2006, and accrual is ongoing. Second, does the combination of two biologic agents improve efficacy outcomes in pancreatic NETs? A CALGB study (80701, NCT01229943) addresses this question and randomly selects patients with advanced pancreatic NETs to receive everolimus and octreotide long-acting release (LAR) versus everolimus, bevacizumab, and octreotide LAR. The primary endpoint is PFS. The study opened in October 2010, and accrual is ongoing. The development of thoughtful future studies is critical in moving the field forward. In fact, a National Cancer Institute Neuroendocrine Tumor Clinical Trials Planning Meeting 26 held in 2009 identified key unmet needs, recommended appropriate study endpoints and inclusion criteria, and formulated priorities for future NET studies. The prospective evaluation of single-agent temozolomide and a comparision to temozolomide-based combinations for pancreatic NETs was a key recommendation of this meeting. ECOG 2211 is a proposed study in which patients with advanced pancreatic NETs will be randomly selected to receive temozolomide versus temozolomide and capecitabine. The principal objective of the study will be to assess whether the addition of capecitabine to temozolomide improves RRs when compared to temozolomide alone. It is anticipated that the superior arm will serve as a building block in future studies. Conclusion The recent advances in the field of pancreatic NETs are truly exciting. We now have additional agents in our arsenal of therapeutic options for patients with this disease, including everolimus and sunitinib, both of which have been shown to prolong PFS. Given the increasing number 273
of therapeutic options, patient selection and treatment sequence can be complicated. A number of tools are available for the treating physician, including the National Comprehensive Cancer Network Neuroendocrine Tumor Guidelines 27 and guidelines from the North American Neuroendocrine Tumor Society. 28 Additionally, a multidis- Author’s Disclosure of Potential Conflicts of Interest ciplinary approach can be helpful as modalities from medical oncology, interventional radiology, and surgery need to be weighed. Future studies are aimed at answering questions about the utility of somatostatin analogs for tumor control, use of combined biologics, and temozolomide-based chemotherapy regimens. Employment or Leadership Consultant or Stock Research Author Positions Advisory Role Ownership Honoraria Funding Pamela L. Kunz Roche/Genentech 1. Yao JC, Hassan M, Phan A, et al. One hundred years after “carcinoid”: epidemiology of and prognostic factors for neuroendocrine tumors in 35,825 cases in the United States. J Clin Oncol. 2008;26:3063-3072. 2. Yao JC, Eisner MP, Leary C, et al. Population-based study of islet cell carcinoma. Ann Surg Oncol. 2007;14:3492-3500. 3. Klimstra DS, Modlin IR, Adsay NV, et al. Pathology reporting of neuroendocrine tumors: application of the Delphic consensus process to the development of a minimum pathology data set. Am J Surg Pathol. 2010;34: 300-313. 4. Klimstra DS, Modlin IR, Coppola D, et al. The pathologic classification of neuroendocrine tumors: a review of nomenclature, grading, and staging systems. Pancreas. 2010;39:707-712. 5. Ito T, Tanaka M, Sasano H, et al. Preliminary results of a Japanese nationwide survey of neuroendocrine gastrointestinal tumors. J Gastroenterol. 2007;42:497-500. 6. Panzuto F, Nasoni S, Falconi M, et al. Prognostic factors and survival in endocrine tumor patients: comparison between gastrointestinal and pancreatic localization. Endocr Relat Cancer. 2005;12:1083-1092. 7. Yao JC, Shah MH, Ito T, et al. Everolimus for advanced pancreatic neuroendocrine tumors. N Engl J Med. 2011;364:514-523. 8. Raymond E, Dahan L, Raoul JL, et al. Sunitinib malate for the treatment of pancreatic neuroendocrine tumors. N Engl J Med. 2011;364:501- 513. 9. Moertel CG, Lefkopoulo M, Lipsitz S, et al. Streptozocin-doxorubicin, streptozocin-fluorouracil or chlorozotocin in the treatment of advanced isletcell carcinoma. N Engl J Med. 1992;326:519-523. 10. Kouvaraki M, Ajani J, Hoff P, et al. Fluorouracil, doxorubicin, and streptozocin in the treatment of patients with locally advanced and metastatic pancreatic endocrine carcinomas. J Clin Oncol. 2004;22:4762-4771. 11. Cheng P, Saltz L. Failure to confirm major objective antitumor activity of streptozocin and doxorubicin in the treatment of patients with advanced islet cell carcinoma. Cancer. 1999;86:944-948. 12. Ekeblad S, Sundin A, Janson ET, et al. Temozolomide as monotherapy is effective in treatment of advanced malignant neuroendocrine tumors. Clin Cancer Res. 2007;13:2986-2991. 13. Kulke MH, Hornick JL, Frauenhoffer C, et al. O6-methylguanine DNA methyltransferase deficiency and response to temozolomide-based therapy in patients with neuroendocrine tumors. Clin Cancer Res. 2009;15:338-345. 14. Maire F, Hammel P, Faivre S, et al. Temozolomide: a safe and effective treatment for malignant digestive endocrine tumors. Neuroendocrinology. 2009;90:67-72. 15. Kulke M, Stuart K, Enzinger P, et al. Phase II study of temozolomide and thalidomide in patients with metastatic neuroendocrine tumors. J Clin Oncol. 2006;24:401-406. 274 REFERENCES Expert Testimony PAMELA L. KUNZ Other Remuneration 16. Kulke M, Stuart K, Earle C, et al. A phase II study of temozolomide and bevacizumab in patients with advanced neuroendocrine tumors. J Clin Oncol. 2006;24:189s (suppl; abstr 4044). 17. Kulke M, Blaszkowsky L, Zhu A, et al. Phase I/II study of everolimus (RAD001) in combination with temozolomide (TMZ) in patients (pts) with advanced pancreatic neuroendocrine tumors (NET). Gastrointestinal Cancers Symposium Proceedings. 2010 (abstr 223). 18. Fine R, Fogelman D, Schreibman S. Effective treatment of neuroendocrine tumors with temozolomide and capecitabine. J Clin Oncol. 2005;23:361s (suppl; abstr 4216). 19. Murakami J, Lee YJ, Kokeguchi S, et al. Depletion of O6methylguanine-DNA methyltransferase by O6-benzylguanine enhances 5-FU cytotoxicity in colon and oral cancer cell lines. Oncol Rep. 2007;17:1461-1467. 20. Isacoff W, Moss R, Pecora A, et al. Temozolomide/capecitabine therapy for metastatic neuroendocrine tumors of the pancreas: a retrospective review. J Clin Oncol. 2006;24:625s (suppl; abstr 14023). 21. Strosberg JR, Fine RL, Choi J, et al. First-line chemotherapy with capecitabine and temozolomide in patients with metastatic pancreatic endocrine carcinomas. Cancer. 2011;117:268-275. Epub 2010 Sep 7. 22. Kvols LK, Turaga KK, Strosberg J, et al. Role of interventional radiology in the treatment of patients with neuroendocrine metastases in the liver. J Natl Compr Canc Netw. 2009;7:765-772. 23. van Vliet EI, Teunissen JJ, Kam BL, et al. Treatment of gastroenteropancreatic neuroendocrine tumors with peptide receptor radionuclide therapy. Neuroendocrinology. Epub 2012 Jan 10. 24. Kwekkeboom DJ, de Herder WW, Kam BL, et al. Treatment with the radiolabeled somatostatin analog [ 177 Lu-DOTA 0 ,Tyr 3 ] octreotate: toxicity, efficacy, and survival. J Clin Oncol. 2008;26:2124-2130. 25. Rinke A, Muller HH, Schade-Brittinger C, et al. Placebo-controlled, double-blind, prospective, randomized study on the effect of octreotide LAR in the control of tumor growth in patients with metastatic neuroendocrine midgut tumors: a report from the PROMID Study Group. J Clin Oncol. 2009;27:4656-4663. 26. Kulke MH, Siu LL, Tepper JE, et al. Future directions in the treatment of neuroendocrine tumors: consensus report of the National Cancer Institute Neuroendocrine Tumor clinical trials planning meeting. J Clin Oncol. 2011; 29:934-943. 27. Kulke M. NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines): Neuroendocrine Tumors. Version 1. National Comprehensive Cancer Network; 2011. 28. Kulke MH, Anthony LB, Bushnell DL, et al. NANETS treatment guidelines: well-differentiated neuroendocrine tumors of the stomach and pancreas. Pancreas. 2010;39:735-752.
Page 1 and 2:
AMERICAN SOCIETY OF CLINICAL ONCOLO
Page 3 and 4:
American Society of Clinical Oncolo
Page 5 and 6:
American Society of Clinical Oncolo
Page 7 and 8:
New Looks and Challenges for Cooper
Page 9 and 10:
Genitourinary Cancer Best Use of Im
Page 11 and 12:
Research and Standard of Care: Lung
Page 13 and 14:
Practice Management and Information
Page 15 and 16:
2012 ASCO Annual Meeting Disclosure
Page 17 and 18:
Matti S. Aapro, MD Clinique De Geno
Page 19 and 20:
Hedy Lee Kindler, MD The University
Page 21 and 22:
Douglas E. Wood, MD University of W
Page 23 and 24:
Mary Lou Smith, JD, MBA Research Ad
Page 25 and 26:
ASCO and Conquer Cancer Foundation
Page 27 and 28:
Letter from the Editor The theme of
Page 29 and 30:
Adjuvant Therapy for Older Women wi
Page 31 and 32:
TREATMENT FOR OLDER WOMEN WITH BREA
Page 33 and 34:
Page 35 and 36:
Page 37 and 38:
MANAGEMENT OF T1 BREAST CANCERS the
Page 39 and 40:
MANAGEMENT OF T1 BREAST CANCERS Tab
Page 41 and 42:
MANAGEMENT OF T1 BREAST CANCERS Tab
Page 43 and 44:
MANAGEMENT OF T1 BREAST CANCERS 93.
Page 45 and 46:
MANAGEMENT OF T1 BREAST CANCERS 1 c
Page 47 and 48:
ADJUVANT ENDOCRINE THERAPY reductio
Page 49 and 50:
ADJUVANT ENDOCRINE THERAPY which ra
Page 51 and 52:
ADJUVANT ENDOCRINE THERAPY assay is
Page 53 and 54:
A DICKENS TALE OF THE TREATMENT OF
Page 55 and 56:
TREATMENT OF ADVANCED BREAST CANCER
Page 57 and 58:
Page 59 and 60:
Page 61 and 62:
Page 63 and 64:
Page 65 and 66:
A FRESH LOOK AT DUCTAL CARCINOMA IN
Page 67 and 68:
DCIS: OPPORTUNITIES AND UNCHARTED W
Page 69 and 70:
DCIS: OPPORTUNITIES AND UNCHARTED W
Page 71 and 72:
Ductal Carcinoma In Situ, and the I
Page 73 and 74:
DCIS AND INFLUENCE OF RISK FACTORS
Page 75 and 76:
KEY QUESTIONS IN THE LOCO-REGIONAL
Page 77 and 78:
POSTMASTECTOMY RADIATION AND PARTIA
Page 79 and 80:
The Appropriate Extent of Surgery f
Page 81 and 82:
SURGERY FOR EARLY-STAGE BREAST CANC
Page 83 and 84:
BIOLOGY AND LOCAL THERAPY DECISIONS
Page 85 and 86:
Clinical and Imaging Surveillance F
Page 87 and 88:
SURVEILLANCE FOLLOWING BREAST CANCE
Page 89 and 90:
SURVEILLANCE FOLLOWING BREAST CANCE
Page 91 and 92:
Advanced Imaging Techniques for the
Page 93 and 94:
IMAGING TECHNIQUES FOR BREAST CANCE
Page 95 and 96:
IMAGING TECHNIQUES FOR BREAST CANCE
Page 97 and 98:
Update of the Oxford Overview: New
Page 99 and 100:
UPDATE OF THE OXFORD OVERVIEW Fig.
Page 101 and 102:
Page 103 and 104:
Page 105 and 106:
UPDATE OF THE OXFORD OVERVIEW Overv
Page 107 and 108:
Gene Patents and Personalized Medic
Page 109 and 110:
GENE PATENTS AND EFFECTS ON PERSONA
Page 111 and 112:
Chemoprevention for Breast Cancer:
Page 113 and 114:
CHEMOPREVENTION FOR BREAST CANCER T
Page 115 and 116:
CHEMOPREVENTION FOR BREAST CANCER C
Page 117 and 118:
CONTROVERSIES IN PROSTATE CANCER: P
Page 119 and 120:
PROSTATE CANCER RISK REDUCTION men
Page 121 and 122:
PROSTATE CANCER RISK REDUCTION Auth
Page 123 and 124:
PSA SCREENING: HARMS WITHOUT CLEAR
Page 125 and 126:
PSA SCREENING: HARMS WITHOUT CLEAR
Page 127 and 128:
GLIOBLASTOMA: TAKING THE STANDARD O
Page 129 and 130:
GLIOBLASTOMA: BIOLOGY, GENETICS AND
Page 131 and 132:
Page 133 and 134:
Page 135 and 136:
FUTURE DIRECTIONS IN GBM THERAPY pr
Page 137 and 138:
FUTURE DIRECTIONS IN GBM THERAPY Ch
Page 139 and 140:
ESTABLISHING TREATMENTS FOR GLIOBLA
Page 141 and 142:
Page 143 and 144:
Page 145 and 146:
Current Concepts in Brain Tumor Ima
Page 147 and 148:
CONCEPTS IN BRAIN TUMOR IMAGING tum
Page 149 and 150:
CONCEPTS IN BRAIN TUMOR IMAGING Aut
Page 151 and 152:
PERSPECTIVES ON HEADLINE-MAKING NEW
Page 153 and 154:
TTF THERAPY IN GLIOBLASTOMA Fig. 1.
Page 155 and 156:
TTF THERAPY IN GLIOBLASTOMA istics.
Page 157 and 158:
TTF THERAPY IN GLIOBLASTOMA because
Page 159 and 160:
Limitations of Adaptive Clinical Tr
Page 161 and 162:
LIMITATIONS OF ADAPTIVE CLINICAL TR
Page 163 and 164:
LIMITATIONS OF ADAPTIVE CLINICAL TR
Page 165 and 166:
Capturing the Patient Perspective:
Page 167 and 168:
PATIENT-REPORTED OUTCOMES AS TRIAL
Page 169 and 170:
PATIENT-REPORTED OUTCOMES AS TRIAL
Page 171 and 172:
NEW LOOKS AND CHALLENGES FOR COOPER
Page 173 and 174:
NCI NATIONAL CLINICAL TRIALS NETWOR
Page 175 and 176:
Successful Integration of Cooperati
Page 177 and 178:
COG: GIVING NEW MEANING TO COOPERAT
Page 179 and 180:
A Critical Review of the Enrollment
Page 181 and 182:
BLACK PATIENTS AND CANCER CLINICAL
Page 183 and 184:
BLACK PATIENTS AND CANCER CLINICAL
Page 185 and 186:
Trastuzumab Emtansine (T-DM1): Hitc
Page 187 and 188:
T-DM1 AND THERAPEUTIC ANTIBODIES ag
Page 189 and 190:
TARGETING CD30 IN HODGKIN LYMPHOMA
Page 191 and 192:
TARGETING CD30 IN HODGKIN LYMPHOMA
Page 193 and 194:
EARLY DRUG DEVELOPMENT: CASTING A W
Page 195 and 196:
Table 1. Response Rates in Expanded
Page 197 and 198:
Drug Development in the Era of Pers
Page 199 and 200:
that the core pathway is not comple
Page 201 and 202:
This situation is not surprising, g
Page 203 and 204:
Practical Management of Immune-Rela
Page 205 and 206:
the anterior pituitary axis is invo
Page 207 and 208:
TARGETING CRITICAL MOLECULAR ABERRA
Page 209 and 210:
Abl suppression; and 3) the early e
Page 211 and 212:
50% 50% 100% Change in Tumor Size m
Page 213 and 214:
vanced solid tumors, even if they a
Page 215 and 216:
Targeting Molecular Aberrations in
Page 217 and 218:
date. With the advent of gene expre
Page 219 and 220:
consortium to facilitate the testin
Page 221 and 222:
ETHICAL CHALLENGES OF HEALTH CARE R
Page 223 and 224:
HEALTH CARE REFORM AND ONCOLOGY dev
Page 225 and 226:
HEALTH CARE REFORM AND ONCOLOGY aut
Page 227 and 228:
INTERNATIONAL VARIATION IN UNDERSTA
Page 229 and 230:
midcareer physician; in one cross-s
Page 231 and 232:
Table 1. Recommendations for Person
Page 233 and 234:
stances (e.g., stage of career, fam
Page 235 and 236:
elationship” is also acknowledged
Page 237 and 238:
Conclusion In more individualistic
Page 239 and 240:
The Oncologist’s Duty to Provide
Page 241 and 242:
an external observer, but to the pe
Page 243 and 244:
MEDICAL ERRORS IN CANCER CARE: PREV
Page 245 and 246:
DISCLOSING MEDICAL ERRORS Disclosur
Page 247 and 248:
DISCLOSING MEDICAL ERRORS Author’
Page 249 and 250:
PREVENTING MEDICAL ERRORS more diff
Page 251 and 252:
“PERSONALIZED” ONCOLOGY FOR COL
Page 253 and 254:
0.001), progression-free survival (
Page 255 and 256:
mately 40% of patients with colorec
Page 257 and 258:
Table 1. Tumor Marker Utility Gradi
Page 259 and 260:
treatment (tx) for metastatic color
Page 261 and 262:
The Interventional Radiologist Role
Page 263 and 264:
effect. The most common drug that h
Page 265 and 266:
gone forever, no further therapy is
Page 267 and 268:
is irrelevant if it is already rese
Page 269 and 270:
Resection and Thermal Ablation of L
Page 271 and 272:
Author’s Disclosures of Potential
Page 273 and 274:
Minimally Invasive Surgery of Recta
Page 275 and 276:
outcomes; local, wound-site, and di
Page 277 and 278:
Authors’ Disclosures of Potential
Page 279 and 280:
CAO/ARO 04 study—which added oxal
Page 281 and 282:
STAGE III COLON CANCER: WHAT WORKS,
Page 283 and 284:
Table 1. Comparison of Fluoropyrimi
Page 285 and 286: tients with stages II and III color
Page 287 and 288: ized by high fruit, vegetable, poul
Page 289 and 290: Exercise Change trial: a randomized
Page 291 and 292: A New Direction for Pancreatic Canc
Page 293 and 294: Table 1. FOLFIRINOX versus Gemcitab
Page 295 and 296: The Southwest Oncology Group (SWOG)
Page 297 and 298: A Matter of Timing: Is There a Role
Page 299 and 300: an OS benefit with radiation therap
Page 301 and 302: a dose of 50.4 Gy to 59.4 Gy of rad
Page 303 and 304: more commonly given for APC, specia
Page 305 and 306: subcutaneous bolus or infusion. Hal
Page 307 and 308: patients are cared for completely w
Page 309 and 310: Varying Lymphadenectomies for Gastr
Page 311 and 312: Table 1. Regional Lymph Nodes of th
Page 313 and 314: Conclusion There are clear differen
Page 315 and 316: Will Disease Heterogeneity Help Def
Page 317 and 318: prematurely due to poor accrual. 18
Page 319 and 320: Adjuvant Treatments for Localized A
Page 321 and 322: ADJUVANT TREATMENT FOR GASTRIC CANC
Page 323 and 324: LIVER-DIRECTED THERAPEUTIC OPTIONS
Page 325 and 326: ated with unique dose distributions
Page 327 and 328: HCC, with encouraging outcomes in e
Page 329 and 330: tion. Advanced computer-based image
Page 331 and 332: a 5-year survival rate of 70% follo
Page 333 and 334: THE MANAGEMENT OF LESS COMMON BUT C
Page 335: Fig 1. PubMed publications and clin
Page 339 and 340: less informative than the GRETCH an
Page 341 and 342: Table 3. New Agents/Regimens under
Page 343 and 344: combined with concurrent transarter
Page 345 and 346: to optimize the use of erlotinib by
Page 347 and 348: Optimal Use of Imaging to Guide Tre
Page 349 and 350: enhancement seen. Furthermore, the
Page 351 and 352: CASTRATION-RESISTANT PROSTATE CANCE
Page 353 and 354: Fig. 1. FDA regulatory approvals in
Page 355 and 356: Prognostic, Predictive, and Surroga
Page 357 and 358: adhesion molecule and further chara
Page 359 and 360: and treatment options are expanding
Page 361 and 362: KIDNEY CANCER BIOLOGY AND THERAPEUT
Page 363 and 364: Prognostic Factors in Advanced RCC
Page 365 and 366: cell immunotherapy in which a small
Page 367 and 368: New Developments in Urothelial Canc
Page 369 and 370: Novel Approaches in Advanced Urothe
Page 371 and 372: 10. Albers P, Park SI, Niegisch G,
Page 373 and 374: 700 at a dose of 400 mg twice daily
Page 375 and 376: therapy for nonmetastatic prostate
Page 377 and 378: ADJUVANT THERAPY FOR OLDER PATIENTS
Page 379 and 380: Adjuvant Systemic Therapy Adjuvant
Page 381 and 382: with early-stage breast cancer were
Page 383 and 384: clinical trials to generate additio
Page 385 and 386: Adjuvant Treatment of Older Patient
Page 387 and 388:
OLDER PATIENTS WITH LUNG CANCER Fig
Page 389 and 390:
OLDER PATIENTS WITH LUNG CANCER adj
Page 391 and 392:
Considerations and Controversies in
Page 393 and 394:
OLDER PATIENTS WITH ADVANCED CANCER
Page 395 and 396:
Page 397 and 398:
Page 399 and 400:
RECENT CLINICAL HIGHLIGHTS IN GYNEC
Page 401 and 402:
GLOBAL ADVANCES IN GYNECOLOGIC ONCO
Page 403 and 404:
GLOBAL ADVANCES IN GYNECOLOGIC ONCO
Page 405 and 406:
The European Society of Gynaecologi
Page 407 and 408:
ESGO EDUCATIONAL AND RESEARCH ACTIV
Page 409 and 410:
UPFRONT TREATMENT OF OVARIAN CANCER
Page 411 and 412:
ANTIANGIOGENICS AND PARP INHIBITORS
Page 413 and 414:
ANTIANGIOGENICS AND PARP INHIBITORS
Page 415 and 416:
Intraperitoneal Treatment in Ovaria
Page 417 and 418:
INTRAPERITONEAL TREATMENT IN OVARIA
Page 419 and 420:
Dose-Dense Chemotherapy and Neoadju
Page 421 and 422:
CHEMOTHERAPY FOR OVARIAN CANCER Fig
Page 423 and 424:
CHEMOTHERAPY FOR OVARIAN CANCER whi
Page 425 and 426:
UTERINE SARCOMA: CHALLENGING CASES
Page 427 and 428:
HISTOLOGIC FEATURES AND MANAGEMENT
Page 429 and 430:
Page 431 and 432:
Page 433 and 434:
SURGICAL OPTIONS FOR UTERINE SARCOM
Page 435 and 436:
SURGICAL OPTIONS FOR UTERINE SARCOM
Page 437 and 438:
PATIENTS WITH HPV-POSITIVE OROPHARY
Page 439 and 440:
HPV-INDUCED OROPHARYNX CANCER analy
Page 441 and 442:
HPV-INDUCED OROPHARYNX CANCER fract
Page 443 and 444:
Important Early Advances in Squamou
Page 445 and 446:
EARLY ADVANCES IN SCCHN Fig 1. Targ
Page 447 and 448:
Application of Genomic and Proteomi
Page 449 and 450:
GENOMIC AND PROTEOMIC TECHNOLOGIES
Page 451 and 452:
GENOMIC AND PROTEOMIC TECHNOLOGIES
Page 453 and 454:
TREATMENT OF THYROID CANCERS: NEW I
Page 455 and 456:
EVALUATION OF ADVANCED THYROID CANC
Page 457 and 458:
EVALUATION OF ADVANCED THYROID CANC
Page 459 and 460:
Systemic Therapeutic Approaches to
Page 461 and 462:
APPROACHES TO ADVANCED THYROID CANC
Page 463 and 464:
AVOIDING OVERDIAGNOSIS AND OVERTREA
Page 465 and 466:
Table 1. Prevalence of Prostate Can
Page 467 and 468:
Table 3. Potential Risks and Benefi
Page 469 and 470:
Overdiagnosis and Overtreatment of
Page 471 and 472:
een reached by other modeling effor
Page 473 and 474:
east cancer community have FDA-appr
Page 475 and 476:
COSTS OF CANCER CARE: AFFORDABILITY
Page 477 and 478:
REDUCING THE COST OF CANCER CARE Fi
Page 479 and 480:
REDUCING THE COST OF CANCER CARE Th
Page 481 and 482:
REDUCING THE COST OF CANCER CARE de
Page 483 and 484:
Why Hasn’t Genomic Testing Change
Page 485 and 486:
tigators should develop prospective
Page 487 and 488:
MANAGEMENT OF CHRONIC LYMPHOCYTIC L
Page 489 and 490:
PREDICTIVE PARAMETERS IN CLL Table
Page 491 and 492:
PREDICTIVE PARAMETERS IN CLL patien
Page 493 and 494:
Transplant in Chronic Lymphocytic L
Page 495 and 496:
WHEN TO OFFER TRANSPLANTATION IN CL
Page 497 and 498:
WHEN TO OFFER TRANSPLANTATION IN CL
Page 499 and 500:
NEW DEVELOPMENTS IN MYELOPROLIFERAT
Page 501 and 502:
SMALL-MOLECULE INHIBITORS FOR MPN S
Page 503 and 504:
SMALL-MOLECULE INHIBITORS FOR MPN L
Page 505 and 506:
Insights into the Molecular Genetic
Page 507 and 508:
GENETICS OF MYELOPROLIFERATIVE NEOP
Page 509 and 510:
Page 511 and 512:
Page 513 and 514:
Classification of Myeloproliferativ
Page 515 and 516:
CLASSIFICATION AND PROGNOSIS OF MPN
Page 517 and 518:
CLASSIFICATION AND PROGNOSIS OF MPN
Page 519 and 520:
AROUND THE WORLD IN ALMOST 80 MINUT
Page 521 and 522:
LUNG CANCER IN BRAZIL Fig. 1. Relat
Page 523 and 524:
LUNG CANCER IN BRAZIL Fig. 3. Chara
Page 525 and 526:
LUNG CANCER IN BRAZIL Author’s Di
Page 527 and 528:
LUNG CANCER IN CHINA Fig 1. Chinese
Page 529 and 530:
LUNG CANCER IN CHINA well equipped
Page 531 and 532:
Research and Standard of Care: Lung
Page 533 and 534:
LUNG CANCER IN ROMANIA ● Protecti
Page 535 and 536:
LUNG CANCER IN ROMANIA reimbursemen
Page 537 and 538:
A New Model: Physician-Patient Coll
Page 539 and 540:
PHYSICIAN ENGAGEMENT IN ONLINE PATI
Page 541 and 542:
PHYSICIAN ENGAGEMENT IN ONLINE PATI
Page 543 and 544:
LUNG CANCER SCREENING 101 CHAIR Chr
Page 545 and 546:
LUNG CANCER SCREENING The concern i
Page 547 and 548:
LUNG CANCER SCREENING Fig. 1. Guide
Page 549 and 550:
LUNG CANCER SCREENING Fig. 2. Guide
Page 551 and 552:
LUNG CANCER SCREENING 19. Montes RP
Page 553 and 554:
Molecular Testing of Non-Small Cell
Page 555 and 556:
MOLECULAR TESTING AND NSCLC Fig 1.
Page 557 and 558:
MOLECULAR TESTING AND NSCLC logic d
Page 559 and 560:
THYMOMA AND THYMIC CARCINOMA: UPDAT
Page 561 and 562:
MANAGEMENT OF THYMIC CARCINOMA recu
Page 563 and 564:
MANAGEMENT OF THYMIC CARCINOMA Refe
Page 565 and 566:
The Creation of the International T
Page 567 and 568:
ITMIG AS A MODEL FOR RARE DISEASES
Page 569 and 570:
Thymoma: From Chemotherapy to Targe
Page 571 and 572:
SYSTEMIC TREATMENT OF THYMOMA Study
Page 573 and 574:
SYSTEMIC TREATMENT OF THYMOMA cance
Page 575 and 576:
What Is the Best Strategy for Incor
Page 577 and 578:
TREATMENT OF FOLLICULAR LYMPHOMA Fi
Page 579 and 580:
TREATMENT OF FOLLICULAR LYMPHOMA me
Page 581 and 582:
TREATMENT OF FOLLICULAR LYMPHOMA ou
Page 583 and 584:
TREATMENT OPTIONS IN INDOLENT LYMPH
Page 585 and 586:
Page 587 and 588:
Page 589 and 590:
ROLE OF HCT FOR INDOLENT LYMPHOMA T
Page 591 and 592:
ROLE OF HCT FOR INDOLENT LYMPHOMA T
Page 593 and 594:
ROLE OF HCT FOR INDOLENT LYMPHOMA e
Page 595 and 596:
CONTROVERSIES IN MYELOMA: INDUCTION
Page 597 and 598:
TRANSPLANTATION FOR MYELOMA Alterna
Page 599 and 600:
TRANSPLANTATION FOR MYELOMA compare
Page 601 and 602:
TRANSPLANTATION FOR MYELOMA autolog
Page 603 and 604:
CURRENT STATUS OF MYELOMA THERAPY K
Page 605 and 606:
CURRENT STATUS OF MYELOMA THERAPY F
Page 607 and 608:
CURRENT STATUS OF MYELOMA THERAPY T
Page 609 and 610:
Maintenance Therapy for Myeloma: Ho
Page 611 and 612:
MAINTENANCE THERAPY FOR MULTIPLE MY
Page 613 and 614:
Page 615 and 616:
Page 617 and 618:
NEW OPTIONS, NEW QUESTIONS: HOW TO
Page 619 and 620:
THERAPIES FOR PATIENTS WITH METASTA
Page 621 and 622:
Page 623 and 624:
Page 625 and 626:
ANTIEMETICS: CURRENT STANDARDS, EME
Page 627 and 628:
ANTIEMETICS: ASCO GUIDELINE UPDATE
Page 629 and 630:
Page 631 and 632:
Page 633 and 634:
Page 635 and 636:
Chemotherapy-Induced Nausea and Vom
Page 637 and 638:
INCIDENCE AND PREVALENCE OF CHEMOTH
Page 639 and 640:
New Frontiers in Mucositis By Dougl
Page 641 and 642:
MUCOSAL INJURY CAUSED BY CANCER THE
Page 643 and 644:
Page 645 and 646:
Page 647 and 648:
Short- and Long-term Cardiovascular
Page 649 and 650:
Recent Advances in Cardiotoxicity o
Page 651 and 652:
CARDIOTOXICITY OF ANTICANCER THERAP
Page 653 and 654:
CARDIOTOXICITY OF ANTICANCER THERAP
Page 655 and 656:
The Oncologist as the Patient with
Page 657 and 658:
THE ONCOLOGIST AS THE PATIENT OR RE
Page 659 and 660:
Prolonged Febrile Neutropenia in th
Page 661 and 662:
FEBRILE NEUTROPENIA IN PEDIATRIC CA
Page 663 and 664:
FEBRILE NEUTROPENIA IN PEDIATRIC CA
Page 665 and 666:
TREATMENT APPROACHES IN CHILDREN wh
Page 667 and 668:
TREATMENT APPROACHES IN CHILDREN th
Page 669 and 670:
GENETIC COUNSELING OF THE PATIENT W
Page 671 and 672:
CANCER PREDISPOSITION IN CHILDHOOD
Page 673 and 674:
Page 675 and 676:
Page 677 and 678:
Page 679 and 680:
HOW TO MANAGE VERY RARE PEDIATRIC C
Page 681 and 682:
RARE CANCER IN CHILDREN Registries
Page 683 and 684:
Genetic Alterations in Childhood Me
Page 685 and 686:
GENETIC ALTERATIONS IN CHILDHOOD ME
Page 687 and 688:
Desmoid-Type Fibromatosis in Childr
Page 689 and 690:
CHEMOTHERAPY FOR DESMOID TUMOR Tabl
Page 691 and 692:
CHEMOTHERAPY FOR DESMOID TUMOR 14.
Page 693 and 694:
Targeting the Insulin-Like Growth F
Page 695 and 696:
TARGETING THE IGF SYSTEM Fig. 1. Th
Page 697 and 698:
TARGETING THE IGF SYSTEM malignanci
Page 699 and 700:
Hedgehog Pathway in Pediatric Cance
Page 701 and 702:
HEDGEHOG PATHWAY IN PEDIATRIC CANCE
Page 703 and 704:
HEDGEHOG PATHWAY IN PEDIATRIC CANCE
Page 705 and 706:
Development and Refinement of Augme
Page 707 and 708:
ABFM THERAPY FOR PEDIATRIC ALL than
Page 709 and 710:
ABFM THERAPY FOR PEDIATRIC ALL Auth
Page 711 and 712:
RADIOTHERAPY FOR PEDIATRIC HODGKIN
Page 713 and 714:
RADIOTHERAPY FOR PEDIATRIC HODGKIN
Page 715 and 716:
Role of Doxorubicin in Rhabdomyosar
Page 717 and 718:
DOXORUBICIN IN RHABDOMYOSARCOMA 8.
Page 719 and 720:
Identification of Novel Biologic Ta
Page 721 and 722:
NOVEL TARGETS IN THE TREATMENT OF D
Page 723 and 724:
Is Biopsy Safe in Children with New
Page 725 and 726:
SAFETY OF DIPG BIOPSY IN CHILDREN F
Page 727 and 728:
SAFETY OF DIPG BIOPSY IN CHILDREN 1
Page 729 and 730:
CHILDREN WITH DIFFUSE INTRINSIC PON
Page 731 and 732:
Communication and Decision Support
Page 733 and 734:
COMMUNICATION AND DECISION SUPPORT
Page 735 and 736:
Page 737 and 738:
Page 739 and 740:
Planning for the Future: The Role o
Page 741 and 742:
present in the office suite but doe
Page 743 and 744:
Summary and Care Plan are provided.
Page 745 and 746:
DOING IT RIGHT, AND FOR LESS: IMPLE
Page 747 and 748:
CLINICAL PATHWAYS STANDARDIZING PER
Page 749 and 750:
CLINICAL PATHWAYS STANDARDIZING PER
Page 751 and 752:
The Future of Oncology Care with Pe
Page 753 and 754:
quantity. Determining the appropria
Page 755 and 756:
THE ASCO QUALITY ONCOLOGY PRACTICE
Page 757 and 758:
IMPROVING VALUE OF CARE IN ONCOLOGY
Page 759 and 760:
Page 761 and 762:
Page 763 and 764:
PHYSICIAN WELLNESS: COPING WITH REP
Page 765 and 766:
also provides insight on how clinic
Page 767 and 768:
good resource for exploring the pri
Page 769 and 770:
of death or following death and inc
Page 771 and 772:
telephone call to the family, sendi
Page 773 and 774:
New Insights in Cross-Cultural Comm
Page 775 and 776:
CROSS-CULTURAL COMMUNICATION Sideba
Page 777 and 778:
THE ONCOLOGIST, THE PATIENT, AND TH
Page 779 and 780:
estimate of the proportion of their
Page 781 and 782:
exactly the same treatment, even th
Page 783 and 784:
How to Decide Whether to Offer and
Page 785 and 786:
NONSTANDARD THERAPIES FOR ADVANCED
Page 787 and 788:
NONSTANDARD THERAPIES FOR ADVANCED
Page 789 and 790:
TARGETED THERAPIES IN TARGETED OR U
Page 791 and 792:
TARGETED THERAPY IN SARCOMA rates a
Page 793 and 794:
TARGETED THERAPY IN SARCOMA seen in
Page 795 and 796:
TARGETED THERAPY IN SARCOMA recepto
Page 797 and 798:
Adjuvant Treatment of Gastrointesti
Page 799 and 800:
ADJUVANT THERAPY IN HIGH-RISK GASTR
Page 801 and 802:
Management of Tyrosine Kinase Inhib
Page 803 and 804:
TKI-RESISTANT GIST Primary Imatinib
Page 805 and 806:
TKI-RESISTANT GIST Table 2. Clinica
Page 807 and 808:
BIOLOGIC PRINCIPLES OF TARGETED COM
Page 809 and 810:
COMBINING TARGETED AGENTS IN CLINIC
Page 811 and 812:
COMBINING TARGETED AGENTS IN CLINIC
Page 813 and 814:
Combination Therapies Building on t
Page 815 and 816:
COMBINATIONS FOR MELANOMA agents th
Page 817 and 818:
MECHANISMS OF RESISTANCE TO TARGETE
Page 819 and 820:
RESISTANCE MECHANISMS TO MAPK INHIB
Page 821 and 822:
RESISTANCE MECHANISMS TO MAPK INHIB
Page 823 and 824:
Mechanisms of Resistance to Targete
Page 825 and 826:
RESISTANCE TO TARGETED THERAPIES IN
Page 827 and 828:
RESISTANCE TO TARGETED THERAPIES IN
Page 829 and 830:
Translating PI3K-Delta Inhibitors t
Page 831 and 832:
THE STORY OF CAL-101 6% of patients
Page 833 and 834:
PI3 Kinase in Cancer: From Biology
Page 835 and 836:
PI3 KINASE IN CANCER Fig. 1. The PI
Page 837 and 838:
PI3 KINASE IN CANCER Fig. 3. In viv
Page 840:
This publication is supported by an
show all

2012 EDUCATIONAL BOOK - American Society of Clinical Oncology

Create successful ePaper yourself

Delete template?

Save as template?