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Mathematics in Independent Component Analysis

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Chapter 15. Neurocomput<strong>in</strong>g, 69:1485-1501, 2006 211<br />

z ∈ R N <strong>in</strong> <strong>in</strong>put space such that<br />

ρ(z) =� ˆ PnΦ(x) − Φ(z) � 2 n� l�<br />

= k(z, z) − 2 βk α<br />

k=1 i=1<br />

k i k(xi, z) (20)<br />

is m<strong>in</strong>imized. Note that an analytic solution to the pre-image problem has been<br />

given recently <strong>in</strong> case of <strong>in</strong>vertible kernels [16]. In denois<strong>in</strong>g applications it is<br />

hoped that the deliberately neglected dimensions of m<strong>in</strong>or variance conta<strong>in</strong><br />

noise mostly and z represents a denoised version of x. Equation (20) can be<br />

m<strong>in</strong>imized via gradient descent techniques.<br />

4 Applications and simulations<br />

In this section we will first present results and concomitant <strong>in</strong>terpretation<br />

of some experiments with toy data us<strong>in</strong>g different variations of the LICA<br />

denois<strong>in</strong>g algorithm. Next we also present some test simulations us<strong>in</strong>g toy data<br />

of the algorithm dAMUSE. F<strong>in</strong>ally we will discuss the results of apply<strong>in</strong>g the<br />

three different denois<strong>in</strong>g algorithms presented above to a real world problem,<br />

i.e. to enhance prote<strong>in</strong> NMR spectra contam<strong>in</strong>ated with a huge water artifact.<br />

4.1 Denois<strong>in</strong>g with Local ICA applied to toy examples<br />

We will present some sample experimental results us<strong>in</strong>g artificially generated<br />

signals and random noise. As the latter is characterized by a vanish<strong>in</strong>g kurtosis,<br />

the LICA based denois<strong>in</strong>g algorithm uses the component kurtosis for noise<br />

selection.<br />

4.1.1 Discussion of an MDL based subspace selection<br />

In the LICA denois<strong>in</strong>g algorithm the MDL criterion is also used to select the<br />

number of noise components <strong>in</strong> each cluster. This works without prior knowledge<br />

of the noise strength. S<strong>in</strong>ce the estimation is based solely on statistical<br />

properties, it produces suboptimal results <strong>in</strong> some cases, however. In figure 1<br />

we compare, for an artificial signal with a known additive white gaussian noise,<br />

the denois<strong>in</strong>g achieved with the MDL based estimation of the subspace dimension<br />

versus the estimation based on the noise level. The latter is done us<strong>in</strong>g<br />

a threshold on the variances of the components <strong>in</strong> feature space such that<br />

only the signal part is conserved. Fig. 1 shows that the threshold criterion<br />

works slightly better <strong>in</strong> this case, though the MDL based selection can obta<strong>in</strong><br />

a comparable level of denois<strong>in</strong>g. However, the smaller SNR <strong>in</strong>dicates that the<br />

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