Introduction - Uppsala Monitoring Centre

preparations for humans in the form of medication under the pain of
a fine of 500 pounds or more; reserving the work of the pharmacy for
apothecaries.
John Millar (1733–1805) wrote ‘Detached cases however numerous
and well attested are insufficient to support general conclusions.’
Most adverse reaction reports had been either case reports or case
series.
1778 The Société Royale de Médecine became the only competent
authority for the authorization for new medicines. This right was
abolished during the revolution, but was re-established afterwards.
The first pharmacopoeia published in the United States was
compiled for army use and appeared in Philadelphia in 1778.
1779 Wouter van Doeveren, Professor of Medicine at Leiden, (February
8 th 1779): In his ‘Sermo academicus de remedio morbo, sive de
malis, quae hominibus a remedied, sanandi causa adhibitis,
saepenumero accidere solent’ [An academic lecture concerning
deadly remedies, or concerning the illnesses which often are
accustomed to happen from remedies applied in the interests of
cure], warned ‘Lest you will not be too easily persuaded to hand out
medication which may carry the risk of your adding a second ailment
to the first, or through which you may perhaps even invite death or
accelerate it.’ Wouter van Doeveren succeeded Herman Boerhaave
as professor at Leiden and argued against blood-letting, but he
promoted inoculation with cowpox after Leiden had prohibited
vaccination with smallpox (Grootheest, 2003).
1780 ‘Almanach oder Tschenbuch fuer Scheidekunstler und Apotheker’,
[Almanach or Pocket book for chemists and apothecaries] ‘Clinical
Experiments, Histories, and Dissections’ by Francis Home.
Experiment LXXXIV March 16 th 1780
‘Janet Burn, 21, has been subject, for two months to globus
hystericus, fainting fits, frequent vomitings, attended often by
haematemesis. After bleeding, cold water used externally and
internally, Tincture of Rosar, laxatives, &c. were employed in vain, I
ordered extract of hyoscyamus seeds (Henbane). She began with
gr.i. four times a day, and came at last to take gr.viii each time. The
smallest doses were attended with nausea; the greater doses
produced vertigo, and dimness of sight. She continued this medicine
for 20 days, but without success in the cure of the haematemesis, or
even of the vomiting. Hence, notwithstanding Stork’s trials, it neither,
appeared to me antispasmodic, nor anti haemorrhagic.’ (Home,