Introduction - Uppsala Monitoring Centre

1946 September 28 th
1946 November 30 th
1947 January 11 th
maculopapular or haemorrhagic)[49], fever (49), eosinophilia
(Nine of eleven patients)
2. Histamine reactions: headache (55), flushing (43), nausea and
vomiting (1), fall in blood pressure (1)
3. Neurological Disturbances: vertigo (33), tinnitus (13), deafness (6)
4. Local irritation: pain, soreness and induration (15) tingling (2) and
parathesias (3)
5. Miscellaneous problems: diarrhoea (1), albuminuria and casts (2),
purpura haemorrhagica (1) and arthralgia (1)
6. Urine: nine out of ten had hyaline and granular casts
Information given on time to onset and duration of ADRs. Overall
20.5% of patients had adverse reactions and at 3G daily 46% had
reactions, whilst at ≥ 4 G 60% had reactions. When the average
daily dose exceeded 1 Gm there was an increase in the number
of ADRs. (Keefer et al., 1946).
One hundred and four patients. No individual ADR mentioned. Dose
between 1 and 3G daily
General mention: nausea, malaise, fever, renal irritation,
arthralgia, local reactions at site of injection (possibly due to
impurities), tinnitus and dizziness, and skin reactions (urticaria,
maculopapular or generalized dermatitis) (Nichols & Herrell, 1946).
One hundred patients. Dose 1–3 gm daily. No individual ADRs.
1. Vestibular damage with frequent persistence of diminished
response to caloric stimulation for at least several weeks after
dechallenge.
2. Irritation at site of injection and is inversely proportional to the
purity of the product.
3. Histamine-like reactions caused by impurities (Hinshaw et al.,
1946).
Otic Complications. One hundred and sixty one patients. Dose 3 gm
daily. There was definite toxicity in 3% of patients.
1. Hearing problems: 65% had high tone loss and 13.6 % of these
also had low tone loss whilst 32.1% had normal hearing.
2. Vestibular function: caloric stimulation showed a normal response
in 80.2% of patients (Fowler & Seligman, 1947).
1947 June 21 st Thirty one patients received 3 gm of highly purified streptomycin daily