Introduction - Uppsala Monitoring Centre

More documents

Recommendations

Info

Mouth and throat tingling/burning or quinsy 873A, 1845A, H A burnin g N A (Sore mouth) V Elek V burnin g Loss of voice 1798A, H A Swelling of tongue /throat 873A,1845A, H A N Tremor or shivering 873A, 1798A A Hiccup 1662, 1776N, H Vomiting 400 BC, 199, 783A, 1586NA, 1640A, 1651, 1657, 1662, 1694, 1752A, H 1776N, 1789A, 1845N, AVN A AVN V Elek AVN Diarrhoea (c blood) 585 BC, 1662, 1694, 1752A, 1772N, 1789A, 1804A, H A (c blood) N A (c blood) AVN (c blood) V VN Abdominal pain 1662, 1718, 1733,1752A, 1772N, 1790, 1845AN, H N A N N A Gastric erosion or burning 873A, A (gastric heat) A Restlessness/anxie ty H 1789A A
Delirium 78, 783A,1662, 1640, 1845N, H (fits of madness) A N A (mental disturbance) N Muscular weakness 1662, 1817A, 1845A, H A AV Convulsions 370 BC, 1491, 1551, 1619, 1651A, 1662, 1752, 1776A, 1789A, 1790, 1798A, 1845A, H N A AN VN Collapse ?hypotension A Danger of suffocation 1586A, 1662, 1694, 1789A, H V (stertorous breathing) N Bradycardia (palpitation) 199, 873A V A VN V Elek AVN 199, 873A, H V A VN V Elek AVN Hypotension 1845 faintness, 1798 syncope, H V A V V Elek AVN Precordial oppression H A V Elek V Heart failure N V Diuresis 1694, 1733, 1789, H N Dizziness/Giddines 1845A, H VN V
Page 2 and 3:
The Dawn of Drug Safety Myles D B S
Page 4 and 5:
George Mann Publications Contents
Page 6 and 7:
§ References .....................
Page 8 and 9:
Mrs L Lake SRN, SCM for help with t
Page 10 and 11:
and international bodies play a maj
Page 12 and 13:
Mechanism of action Causality Predi
Page 14 and 15:
possible blindness, paralysis of th
Page 16 and 17:
Filipendula ulmaria or Spiraea ulma
Page 18 and 19:
2. Laws and Regulations. a. Prevent
Page 20 and 21:
Algeria, dated 7000-5000 BC, there
Page 22 and 23:
Sennacharib 11 (705-681 BC), which
Page 24 and 25:
(henbane), opium and colchicum. (Ma
Page 26 and 27:
mandragora, mentha, myrrh, opium, p
Page 28 and 29:
16. Hellebore (alias Christmas Rose
Page 30 and 31:
clothes and head-bindings, and thei
Page 32 and 33:
ecovered after a dose of a drug.’
Page 34 and 35:
the Christian era it was well known
Page 36 and 37:
given at such a time, it is sure to
Page 38 and 39:
he strewed powdered Henbane, and li
Page 40 and 41:
The second category of herbs was ca
Page 42 and 43:
1 st quarter of the 2 nd century AD
Page 44 and 45:
The Dark Ages from the 5th to the 8
Page 46 and 47:
ecomes disordered, his tongue swell
Page 48 and 49:
inspected at any time without warni
Page 50 and 51:
done on any “new” product: 1. T
Page 52 and 53:
drugs. It represents the first gove
Page 54 and 55:
not written in the form of tables.
Page 56 and 57:
idea of four humours: blood (sangui
Page 58 and 59:
ordered pharmacists to prepare drug
Page 60 and 61:
No mention of side effects. 1270 A
Page 62 and 63:
population was approximately 6 mill
Page 64 and 65:
ed as blood, red wine, Then would h
Page 66 and 67:
time of his death in 1534 in three
Page 68 and 69:
1497 Syphilis broke out for the fir
Page 70 and 71:
1686 Stockholm ‘Pharmacopoeja Hol
Page 72 and 73:
drugs, from the shores of the Red S
Page 74 and 75:
medical tracts from Avicenna, Razie
Page 76 and 77:
all manner of creatures of God crea
Page 78 and 79:
powders of myrrh, of mastic, of cer
Page 80 and 81:
swollen in the interior, that first
Page 82 and 83:
mercury is the special best remedy
Page 84 and 85:
78 Uncomes = whitlows will use it i
Page 86 and 87:
nightshade; but not without great e
Page 88 and 89:
may be chosen the best and most luc
Page 90 and 91:
‘A New Herball: Wherein are conta
Page 92 and 93:
such an enmity with blood of man.
Page 94 and 95:
The surprise visitation was carried
Page 96 and 97:
nature of it, unto this may be adde
Page 98 and 99:
sometimes they so trouble the brain
Page 100 and 101:
as you will use, and boil it 6. or
Page 102 and 103:
Dose filthy; and much more after a
Page 104 and 105:
Dichotomy In all people there is so
Page 106 and 107:
it Venom, Venom! Poison, say they (
Page 108 and 109:
or the dominions beyond thereof.’
Page 110 and 111:
Quinsy = tonsillitis Spotted fever
Page 112 and 113:
1652 Culpeper, Nicholas, (1616-1654
Page 114 and 115:
Figure 7. The Expert Doctor’s Dis
Page 116 and 117:
themselves with brawling and alterc
Page 118 and 119:
principles of the art of physick’
Page 120 and 121:
Poisons upon Animals, etc.’ Made
Page 122 and 123:
First medical journal ‘Medicina C
Page 124 and 125:
Closed in 1725 (Warren, http://www.
Page 126 and 127:
for each drug especially for helleb
Page 128 and 129:
hurry of the spirits, causes rest a
Page 130 and 131:
3. 1736 Frederich Hoffmann wrote th
Page 132 and 133:
Francois Chicanneau. This contains
Page 134 and 135:
can only be obtained by a just acqu
Page 136 and 137:
Pills about him, left Gilbert Jones
Page 138 and 139:
George Key wrote ‘A dissertation
Page 140 and 141:
sometimes excites convulsions.’ H
Page 142 and 143:
drugs’ said of henbane: ‘The bl
Page 144 and 145:
ut it would not become generally us
Page 146 and 147:
hiccoughs*; convulsions; syncopes,
Page 148 and 149:
avec leurs antidotes; rédigée d
Page 150 and 151:
1780). 1781 ‘Observations on the
Page 152 and 153:
emarked that it was a violent medic
Page 154 and 155:
Figure 8 Arsenic © Wellcome Images
Page 156 and 157:
oppression of the breast, fever, he
Page 158 and 159:
of former authors on these points i
Page 160 and 161:
Vernor and Hood, London, 1798. ‘I
Page 162 and 163:
Vaccines pharmacovigilance data. Wh
Page 164 and 165:
that I can find where the phrase
Page 166 and 167:
Physician/scientist Drug taken ADRs
Page 168 and 169:
Physician/scientist Drug taken ADRs
Page 170 and 171:
Chapter 7. 19 th Century A lchemy h
Page 172 and 173:
White Hellebore: ‘violent purging
Page 174 and 175:
medicine as potentized development
Page 176 and 177:
vomiting, increase discharge of uri
Page 178 and 179:
How many patients have they lost? H
Page 180 and 181:
diarrhoea…If plentifully prescrib
Page 182 and 183:
1841 Sir Astley Cooper gave the eff
Page 184 and 185:
The UK House of Commons Select Comm
Page 186 and 187:
Kolbe and Lautemann made synthetic
Page 188 and 189:
predisposition that one cannot call
Page 190 and 191:
this it may be noted that the major
Page 192 and 193:
emulsion. To the strained emulsion,
Page 194 and 195:
eruptions. The first study of a dru
Page 196 and 197:
‘It presents several advantages o
Page 198 and 199: as the charlatans continued to flou
Page 200 and 201: digoxin. It was not until the explo
Page 202 and 203: eported in Australia as early as th
Page 204 and 205: 1907 Synthesis of arsphenamine (Sal
Page 206 and 207: The bill was strongly opposed by th
Page 208 and 209: James McDonagh, referring to Salava
Page 210 and 211: erythema, spasmodic coryza, an atta
Page 212 and 213: their confidence. Certainly the med
Page 214 and 215: 1935 First use of prontosil red (su
Page 216 and 217: groups admitted patients on alterna
Page 218 and 219: These postulates governed toxicolog
Page 220 and 221: some of the herbs: hellebore, hemlo
Page 222 and 223: and treatment. It deals with methyl
Page 224 and 225: USA, because less than 1% of new co
Page 226 and 227: 1981). Dr Kelsey said at an open pu
Page 228 and 229: Germany, particularly for use in ch
Page 230 and 231: must be due to some recently introd
Page 232 and 233: This of course will add to more rap
Page 234 and 235: 1878) The latter being urticaria. 1
Page 236 and 237: Poison the cow-pox, that the dispos
Page 238 and 239: Persistence of drugs As explained a
Page 240 and 241: have and have not had an exposure t
Page 242 and 243: types of reactions: Lewin’s ‘Th
Page 244 and 245: knowledge of medicine and science.
Page 246 and 247: scurvy in 12 patients, i.e. two pat
Page 250 and 251: s Sneezing (nasal use) 1586A,1657,
Page 252 and 253: types of hellebore. There was a gap
Page 254 and 255: 1546, 1565, 1752, 1789 Troubles in
Page 256 and 257: Weakness 873, 1763, 1652, x x x Hea
Page 258 and 259: ‘maketh man mad and foolish’ co
Page 260 and 261: Mixtures: Donovan’s solution (Liq
Page 262 and 263: Swollen tongue Ulceration of gums 1
Page 264 and 265: Polyneuropathy enemy of the nerves
Page 266 and 267: Headache 1711, 1733 1736, 1752 1788
Page 268 and 269: 1806 Cough 1590, 1804 1806 x Conjun
Page 270 and 271: The loss of hair has only been repo
Page 272 and 273: the responsible organism, Treponema
Page 274 and 275: Loss of memory 1586, 1619,1763 x Im
Page 276 and 277: Antidiuretic effect 1776 urine inse
Page 278 and 279: Nausea/vomiting # 1876 2,81,19 , 18
Page 280 and 281: alkalosis * 1949 26 Hypoglycaemia 1
Page 282 and 283: Drowsiness 1881 28 , 1884 86 , 1909
Page 284 and 285: Papilloedema 1965 37 , 1965 37 Myop
Page 286 and 287: Pancytopenia 1966 32 VI 1968 F D Me
Page 288 and 289: SED = Meyler’s Side Effects of Dr
Page 290 and 291: 29. Williams JO, Mengel CE, Sulliva
Page 292 and 293: Aspirin. 57. Al-Abbasi AH. Salicyla
Page 294 and 295: 282. Headache, giddiness, tinnitus,
Page 296 and 297: ullous eruption < 1 % and purpura.
Page 298 and 299:
dose Aspirin produces generally its
Page 300 and 301:
Douthwaite and Lintott first showed
Page 302 and 303:
Chapter 14. Streptomycin treptomyci
Page 304 and 305:
1946 September 28 th 1946 November
Page 306 and 307:
1947 Forty patients. Dose 3.0 gm da
Page 308 and 309:
cheeks, & the blood kept coming up
Page 310 and 311:
‘By far the most important toxic
Page 312 and 313:
In their study 1.6% of patients dis
Page 314 and 315:
Renal dysfunction Vision- Yellow Di
Page 316 and 317:
(Crofton, 2009). Asthma, pancytopen
Page 318 and 319:
Ideal knowledge of an ADR How much
Page 320 and 321:
Table 13. Number of first reports o
Page 322 and 323:
Despite these actions the prescribe
Page 324 and 325:
Remedy, the active ingredient was D
Page 326 and 327:
on the lips (Thorwald, 1962) Uses:
Page 328 and 329:
Comment: the side effects were seve
Page 330 and 331:
SED 1952: habituation causes sympto
Page 332 and 333:
and acuity, dementia, inability to
Page 334 and 335:
have expected that it would have be
Page 336 and 337:
the poor economic status of these a
Page 338 and 339:
SED 1952: no mention. A warning was
Page 340 and 341:
Withdrawn: over-the-counter sales w
Page 342 and 343:
(ADEC, 1971). It is unlikely that c
Page 344 and 345:
dose for six months, mice also deve
Page 346 and 347:
symptoms.’ (Willcox, 1934). SED 1
Page 348 and 349:
Comment: a Lancet editorial entitle
Page 350 and 351:
1933 Dinitrophenol (2,4-dinitrophen
Page 352 and 353:
1995). SED 1952: the same side effe
Page 354 and 355:
Delay in recognition: None Delay in
Page 356 and 357:
In 1958 Garrod reported an approxim
Page 358 and 359:
purpura, toxic hepatitis, and aplas
Page 360 and 361:
area and degree of inflammation. 19
Page 362 and 363:
1952 Iproniazid (Marsilid) Was intr
Page 364 and 365:
SED 1960: addiction frequently obse
Page 366 and 367:
cutaneous sarcoidosis, erythema mul
Page 368 and 369:
1957 Ethchlorvynol (Placidyl, Seren
Page 370 and 371:
Official warnings were sent out in
Page 372 and 373:
Delay in recognition: ≤ one year
Page 374 and 375:
Withdrawn: USA 1962 Availability: n
Page 376 and 377:
new original reports. Table 16. Num
Page 378 and 379:
eporting (Griffin & Weber, 1986), b
Page 380 and 381:
John Abraham and Helen Lawton Smith
Page 382 and 383:
and nialamide; biguanides, e.g. buf
Page 384 and 385:
see Hart PW in ‘Blood dyscrasias
Page 386 and 387:
used in 1779 with reference to toba
Page 388 and 389:
perhaps even stranger that there we
Page 390 and 391:
of benefit to me.’ The first rule
Page 392 and 393:
government authority including perf
Page 394 and 395:
4) There was less risk of having an
Page 396 and 397:
adverse effects more willingly. Now
Page 398 and 399:
to restrict or withdraw a drug. ‘
Page 400 and 401:
Armer RE and Morris ID. Trends in e
Page 402 and 403:
Brookes R. (Richard). An introducti
Page 404 and 405:
www.ordre.pharmacien.fr/upload/Synt
Page 406 and 407:
of prescription drugs from worldwid
Page 408 and 409:
Herbst Al, Vilfelder H and Posakanz
Page 410 and 411:
Kereković M and Curković M. Olfac
Page 412 and 413:
Med 2008;101: 148-155. Louis PCA. R
Page 414 and 415:
MRC. At National Archives: FD1/6769
Page 416 and 417:
Reynolds TB, Lapin AC, Peters RL an
Page 418 and 419:
Solecki RS. Shanidar IV, a Neandert
Page 420 and 421:
Vépan. Gaz Medic. De Strassb. 1865
show all

Introduction - Uppsala Monitoring Centre

Create successful ePaper yourself

Delete template?

Save as template?