Introduction - Uppsala Monitoring Centre

Aspirin.
57. Al-Abbasi AH. Salicylate-induced variant angina. American Heart Journal. 1983; 106(6):
1450.
58. Wégria R and Smull K. Salicylate therapy and acute rheumatic fever. J. Amer. Med.
Assoc. 1945; 129: 485 - 490. Toxic over 50 mgm per 100cc. Tinnitus, deafness, nausea
and vomiting, hypernoea, sinus bradycardia, apathy, drowsiness, auditory and visual
hallucinations, albuminuria, stuporous and unconscious.
59. Odin M. Acta Med. Scand. Suppl. 1932; 50: 177. Respiratory alkalosis, tinnitus,
deafness, thirst, dizziness, sweating, sinus tachycardia, bradycardia, fever, anaphylaxis,
albuminuria and stomach pain.
60. Shapiro S, Siskind V, Monson RR, Heinonen OP, Kaufman DW, Slone D. Perinatal
mortality and birth-weight in relation to aspirin taken during pregnancy. Lancet. 1976; 1:
1375 – 1376.
61. Miwa K, Kambara H and Kawai C. Variant angina aggravated by aspirin. Lancet. 1979;
Dec. 22/29: 1382. Single case against control.
62. Wohlgemuth. Aspirin. BMJ. 1899; July 1 st , and Therap Monat, 1899; May. One of 10
cases: pain in the stomach.
63. Rich RR and Johnson JS. Salicylate hepatotoxicity in patients with juvenile rheumatoid
arthritis. Arthritis Rheum. 1973; 16: 1 - 9. Six patients
64. Velo GP and Milanino R. Non-gastrointestinal adverse reactions to NSAID. Journal of
Rheumatology. 1990; Suppl 2017: 42 – 5.
65. Maclagan TJ. The treatment of acute rheumatism by salicin and salicylic acid. Lancet.
1879; June 21 st : 875 - 877. Salicylic acid caused irritation of the throat and stomach and
also alarming depression. Its taste was disagreeably sweet and nauseous giving
copious perspiration, increasing the pulse rate and singing in the ears.
66. Korol EA. Zdravookhr Beloruss. 1962; 8: 66. Single case of myopia with raised
intraocular tension.
67. Pretty HM, Gosselin G, Colpron G , Long LA. Agranulocytosis: a report of 30 cases.
Canadian Medical Association Journal. 1965; Nov 1393(20):1058 - 64.
68. Duggan JM. The relationship between perforated peptic ulcer and aspirin ingestion.
Medical Journal of Australia. 1965; Oct 162(16): 659 - 62.
69. Karunaratne WAE. A case of Aspirin idiosyncrasy. BMJ. 1919; July 12 th . Oedema face,
forehead and neck, erythematous rash, albuminuria, sensation of choking, and skin
irritation. Positive rechallenge.
70. Myers ABR. Salicin in acute rheumatism. Lancet, 1876; November 11 th: 676 - 7. Several
cases of haemorrhagic erosions in mucous membrane of the stomach and intestines.
71. Neale AV. Aspirin poisoning. BMJ. 1936; 1: 109 - 110. Five cases: nausea and vomiting,
sweating, disorientated, perspiring, thirst, dehydration, coma, death, convulsions,
delirious, albuminuria, vision streaked and choking sensation.
72. Franke. Vergiftungserscheinungen nach Aspirin. Muencher Medizinische
Wochenschrift. 1903; July 28 th . Single case (the author): 1 gramme (15.4grs) Aspirin.