Introduction - Uppsala Monitoring Centre

More documents

Recommendations

Info

1546, 1565, 1752, 1789 Troubles in reason 77, 100, 150, 873, 1398,1610, 1649, 1652, 1676, 1729, 1733, 1752, 1776, 1781 Loss of memory 1781 x x Delirium 1751, 1752 x x x x x Hallucinations x x x Irritability 1776 x x x Aggressive rage 1619, 1657, 1671, 1776, 1781 x x Drunk 1590, 1597, 1619, x x x
1751, 1776 Dysphagia 1756, 1776, 1781 x x x x Abdominal cramps 1756, 1763, 1776 x x x x Diarrhoea 1776 x x Dysarthria x x Urine retention x Diuresis x x Rash x x x x x Allergic symptoms Tongue swells 1873 x Sweating (cold) x x x
Page 2 and 3:
The Dawn of Drug Safety Myles D B S
Page 4 and 5:
George Mann Publications Contents
Page 6 and 7:
§ References .....................
Page 8 and 9:
Mrs L Lake SRN, SCM for help with t
Page 10 and 11:
and international bodies play a maj
Page 12 and 13:
Mechanism of action Causality Predi
Page 14 and 15:
possible blindness, paralysis of th
Page 16 and 17:
Filipendula ulmaria or Spiraea ulma
Page 18 and 19:
2. Laws and Regulations. a. Prevent
Page 20 and 21:
Algeria, dated 7000-5000 BC, there
Page 22 and 23:
Sennacharib 11 (705-681 BC), which
Page 24 and 25:
(henbane), opium and colchicum. (Ma
Page 26 and 27:
mandragora, mentha, myrrh, opium, p
Page 28 and 29:
16. Hellebore (alias Christmas Rose
Page 30 and 31:
clothes and head-bindings, and thei
Page 32 and 33:
ecovered after a dose of a drug.’
Page 34 and 35:
the Christian era it was well known
Page 36 and 37:
given at such a time, it is sure to
Page 38 and 39:
he strewed powdered Henbane, and li
Page 40 and 41:
The second category of herbs was ca
Page 42 and 43:
1 st quarter of the 2 nd century AD
Page 44 and 45:
The Dark Ages from the 5th to the 8
Page 46 and 47:
ecomes disordered, his tongue swell
Page 48 and 49:
inspected at any time without warni
Page 50 and 51:
done on any “new” product: 1. T
Page 52 and 53:
drugs. It represents the first gove
Page 54 and 55:
not written in the form of tables.
Page 56 and 57:
idea of four humours: blood (sangui
Page 58 and 59:
ordered pharmacists to prepare drug
Page 60 and 61:
No mention of side effects. 1270 A
Page 62 and 63:
population was approximately 6 mill
Page 64 and 65:
ed as blood, red wine, Then would h
Page 66 and 67:
time of his death in 1534 in three
Page 68 and 69:
1497 Syphilis broke out for the fir
Page 70 and 71:
1686 Stockholm ‘Pharmacopoeja Hol
Page 72 and 73:
drugs, from the shores of the Red S
Page 74 and 75:
medical tracts from Avicenna, Razie
Page 76 and 77:
all manner of creatures of God crea
Page 78 and 79:
powders of myrrh, of mastic, of cer
Page 80 and 81:
swollen in the interior, that first
Page 82 and 83:
mercury is the special best remedy
Page 84 and 85:
78 Uncomes = whitlows will use it i
Page 86 and 87:
nightshade; but not without great e
Page 88 and 89:
may be chosen the best and most luc
Page 90 and 91:
‘A New Herball: Wherein are conta
Page 92 and 93:
such an enmity with blood of man.
Page 94 and 95:
The surprise visitation was carried
Page 96 and 97:
nature of it, unto this may be adde
Page 98 and 99:
sometimes they so trouble the brain
Page 100 and 101:
as you will use, and boil it 6. or
Page 102 and 103:
Dose filthy; and much more after a
Page 104 and 105:
Dichotomy In all people there is so
Page 106 and 107:
it Venom, Venom! Poison, say they (
Page 108 and 109:
or the dominions beyond thereof.’
Page 110 and 111:
Quinsy = tonsillitis Spotted fever
Page 112 and 113:
1652 Culpeper, Nicholas, (1616-1654
Page 114 and 115:
Figure 7. The Expert Doctor’s Dis
Page 116 and 117:
themselves with brawling and alterc
Page 118 and 119:
principles of the art of physick’
Page 120 and 121:
Poisons upon Animals, etc.’ Made
Page 122 and 123:
First medical journal ‘Medicina C
Page 124 and 125:
Closed in 1725 (Warren, http://www.
Page 126 and 127:
for each drug especially for helleb
Page 128 and 129:
hurry of the spirits, causes rest a
Page 130 and 131:
3. 1736 Frederich Hoffmann wrote th
Page 132 and 133:
Francois Chicanneau. This contains
Page 134 and 135:
can only be obtained by a just acqu
Page 136 and 137:
Pills about him, left Gilbert Jones
Page 138 and 139:
George Key wrote ‘A dissertation
Page 140 and 141:
sometimes excites convulsions.’ H
Page 142 and 143:
drugs’ said of henbane: ‘The bl
Page 144 and 145:
ut it would not become generally us
Page 146 and 147:
hiccoughs*; convulsions; syncopes,
Page 148 and 149:
avec leurs antidotes; rédigée d
Page 150 and 151:
1780). 1781 ‘Observations on the
Page 152 and 153:
emarked that it was a violent medic
Page 154 and 155:
Figure 8 Arsenic © Wellcome Images
Page 156 and 157:
oppression of the breast, fever, he
Page 158 and 159:
of former authors on these points i
Page 160 and 161:
Vernor and Hood, London, 1798. ‘I
Page 162 and 163:
Vaccines pharmacovigilance data. Wh
Page 164 and 165:
that I can find where the phrase
Page 166 and 167:
Physician/scientist Drug taken ADRs
Page 168 and 169:
Physician/scientist Drug taken ADRs
Page 170 and 171:
Chapter 7. 19 th Century A lchemy h
Page 172 and 173:
White Hellebore: ‘violent purging
Page 174 and 175:
medicine as potentized development
Page 176 and 177:
vomiting, increase discharge of uri
Page 178 and 179:
How many patients have they lost? H
Page 180 and 181:
diarrhoea…If plentifully prescrib
Page 182 and 183:
1841 Sir Astley Cooper gave the eff
Page 184 and 185:
The UK House of Commons Select Comm
Page 186 and 187:
Kolbe and Lautemann made synthetic
Page 188 and 189:
predisposition that one cannot call
Page 190 and 191:
this it may be noted that the major
Page 192 and 193:
emulsion. To the strained emulsion,
Page 194 and 195:
eruptions. The first study of a dru
Page 196 and 197:
‘It presents several advantages o
Page 198 and 199:
as the charlatans continued to flou
Page 200 and 201:
digoxin. It was not until the explo
Page 202 and 203:
eported in Australia as early as th
Page 204 and 205: 1907 Synthesis of arsphenamine (Sal
Page 206 and 207: The bill was strongly opposed by th
Page 208 and 209: James McDonagh, referring to Salava
Page 210 and 211: erythema, spasmodic coryza, an atta
Page 212 and 213: their confidence. Certainly the med
Page 214 and 215: 1935 First use of prontosil red (su
Page 216 and 217: groups admitted patients on alterna
Page 218 and 219: These postulates governed toxicolog
Page 220 and 221: some of the herbs: hellebore, hemlo
Page 222 and 223: and treatment. It deals with methyl
Page 224 and 225: USA, because less than 1% of new co
Page 226 and 227: 1981). Dr Kelsey said at an open pu
Page 228 and 229: Germany, particularly for use in ch
Page 230 and 231: must be due to some recently introd
Page 232 and 233: This of course will add to more rap
Page 234 and 235: 1878) The latter being urticaria. 1
Page 236 and 237: Poison the cow-pox, that the dispos
Page 238 and 239: Persistence of drugs As explained a
Page 240 and 241: have and have not had an exposure t
Page 242 and 243: types of reactions: Lewin’s ‘Th
Page 244 and 245: knowledge of medicine and science.
Page 246 and 247: scurvy in 12 patients, i.e. two pat
Page 248 and 249: Mouth and throat tingling/burning o
Page 250 and 251: s Sneezing (nasal use) 1586A,1657,
Page 252 and 253: types of hellebore. There was a gap
Page 256 and 257: Weakness 873, 1763, 1652, x x x Hea
Page 258 and 259: ‘maketh man mad and foolish’ co
Page 260 and 261: Mixtures: Donovan’s solution (Liq
Page 262 and 263: Swollen tongue Ulceration of gums 1
Page 264 and 265: Polyneuropathy enemy of the nerves
Page 266 and 267: Headache 1711, 1733 1736, 1752 1788
Page 268 and 269: 1806 Cough 1590, 1804 1806 x Conjun
Page 270 and 271: The loss of hair has only been repo
Page 272 and 273: the responsible organism, Treponema
Page 274 and 275: Loss of memory 1586, 1619,1763 x Im
Page 276 and 277: Antidiuretic effect 1776 urine inse
Page 278 and 279: Nausea/vomiting # 1876 2,81,19 , 18
Page 280 and 281: alkalosis * 1949 26 Hypoglycaemia 1
Page 282 and 283: Drowsiness 1881 28 , 1884 86 , 1909
Page 284 and 285: Papilloedema 1965 37 , 1965 37 Myop
Page 286 and 287: Pancytopenia 1966 32 VI 1968 F D Me
Page 288 and 289: SED = Meyler’s Side Effects of Dr
Page 290 and 291: 29. Williams JO, Mengel CE, Sulliva
Page 292 and 293: Aspirin. 57. Al-Abbasi AH. Salicyla
Page 294 and 295: 282. Headache, giddiness, tinnitus,
Page 296 and 297: ullous eruption < 1 % and purpura.
Page 298 and 299: dose Aspirin produces generally its
Page 300 and 301: Douthwaite and Lintott first showed
Page 302 and 303: Chapter 14. Streptomycin treptomyci
Page 304 and 305:
1946 September 28 th 1946 November
Page 306 and 307:
1947 Forty patients. Dose 3.0 gm da
Page 308 and 309:
cheeks, & the blood kept coming up
Page 310 and 311:
‘By far the most important toxic
Page 312 and 313:
In their study 1.6% of patients dis
Page 314 and 315:
Renal dysfunction Vision- Yellow Di
Page 316 and 317:
(Crofton, 2009). Asthma, pancytopen
Page 318 and 319:
Ideal knowledge of an ADR How much
Page 320 and 321:
Table 13. Number of first reports o
Page 322 and 323:
Despite these actions the prescribe
Page 324 and 325:
Remedy, the active ingredient was D
Page 326 and 327:
on the lips (Thorwald, 1962) Uses:
Page 328 and 329:
Comment: the side effects were seve
Page 330 and 331:
SED 1952: habituation causes sympto
Page 332 and 333:
and acuity, dementia, inability to
Page 334 and 335:
have expected that it would have be
Page 336 and 337:
the poor economic status of these a
Page 338 and 339:
SED 1952: no mention. A warning was
Page 340 and 341:
Withdrawn: over-the-counter sales w
Page 342 and 343:
(ADEC, 1971). It is unlikely that c
Page 344 and 345:
dose for six months, mice also deve
Page 346 and 347:
symptoms.’ (Willcox, 1934). SED 1
Page 348 and 349:
Comment: a Lancet editorial entitle
Page 350 and 351:
1933 Dinitrophenol (2,4-dinitrophen
Page 352 and 353:
1995). SED 1952: the same side effe
Page 354 and 355:
Delay in recognition: None Delay in
Page 356 and 357:
In 1958 Garrod reported an approxim
Page 358 and 359:
purpura, toxic hepatitis, and aplas
Page 360 and 361:
area and degree of inflammation. 19
Page 362 and 363:
1952 Iproniazid (Marsilid) Was intr
Page 364 and 365:
SED 1960: addiction frequently obse
Page 366 and 367:
cutaneous sarcoidosis, erythema mul
Page 368 and 369:
1957 Ethchlorvynol (Placidyl, Seren
Page 370 and 371:
Official warnings were sent out in
Page 372 and 373:
Delay in recognition: ≤ one year
Page 374 and 375:
Withdrawn: USA 1962 Availability: n
Page 376 and 377:
new original reports. Table 16. Num
Page 378 and 379:
eporting (Griffin & Weber, 1986), b
Page 380 and 381:
John Abraham and Helen Lawton Smith
Page 382 and 383:
and nialamide; biguanides, e.g. buf
Page 384 and 385:
see Hart PW in ‘Blood dyscrasias
Page 386 and 387:
used in 1779 with reference to toba
Page 388 and 389:
perhaps even stranger that there we
Page 390 and 391:
of benefit to me.’ The first rule
Page 392 and 393:
government authority including perf
Page 394 and 395:
4) There was less risk of having an
Page 396 and 397:
adverse effects more willingly. Now
Page 398 and 399:
to restrict or withdraw a drug. ‘
Page 400 and 401:
Armer RE and Morris ID. Trends in e
Page 402 and 403:
Brookes R. (Richard). An introducti
Page 404 and 405:
www.ordre.pharmacien.fr/upload/Synt
Page 406 and 407:
of prescription drugs from worldwid
Page 408 and 409:
Herbst Al, Vilfelder H and Posakanz
Page 410 and 411:
Kereković M and Curković M. Olfac
Page 412 and 413:
Med 2008;101: 148-155. Louis PCA. R
Page 414 and 415:
MRC. At National Archives: FD1/6769
Page 416 and 417:
Reynolds TB, Lapin AC, Peters RL an
Page 418 and 419:
Solecki RS. Shanidar IV, a Neandert
Page 420 and 421:
Vépan. Gaz Medic. De Strassb. 1865
show all

Introduction - Uppsala Monitoring Centre

Create successful ePaper yourself

Delete template?

Save as template?