Introduction - Uppsala Monitoring Centre

Table 13. Number of first reports of adverse events with Aspirin
Decade Aspirin
1890s 5 Introduction of Aspirin
1900s 20
1910s 4
1920s 3
1930s 15
1940s 18
1950s 5 Paracetamol introduced
1960s 15 Ibuprofen introduced
1970s 3 Use as anticoagulant
1980s 3
1990s 2
2000 2
For streptomycin again there is another pattern, after its introduction it became
apparent that the TB bacteria became resistant to streptomycin and the same
occurred to its replacement, PAS (para-aminosalicylate sodium) in 1948, but the
combination of the two drugs in 1950 largely prevented the bacteria from becoming
resistant. The continual production of better drugs meant that streptomycin became
a second-line drug. The reduction in the number of reports may reflect its decreased
usage or a decline because all the ADRs were now known. the three cases
mentioned in SED 2000 were originally reported in 1971, 1977 and 1982.
Table 14. First reports of adverse events with Streptomycin
1945 15
1946 8 Resistance discovered
1947 6
1948 3 PAS discovered
1951 1
SED1952 1
SED1857 -
SED1958 2
SED1960 -