Introduction - Uppsala Monitoring Centre

diclofenac.
100. Hawkinson O and Kerr EK. A case of granulocytopenia with severe anaemia and
staphylococcemia. Illinois Medical Journal. 1943; 81: 168 - 170. Single complicated
case after long-term use of 40 – 60 grain Aspirin daily.
101. Balazs J. Uber Azetylsalzylsäure (Aspirin). Vergiftungen, Med. Klin. 1930; 26: 1664 –
1666. Cardiac depression.
102. Lees DB. The effective treatment of acute and subacute rheumatism. Proc. R. Soc.
Med. 1909; 2: 34 – 48. Coma, air-hunger, drowsiness, tinnitus, acetonuria, vomiting,
deafness, vertigo, and delirium.
103. Gebert Karl. Die Atmung nach Therapeutische Salicylgaben [Respiration after
therapeutic administration of salicyl]. Thesis, Friedrich-Wilhelm Univ. Berlin. 1931.
Respiratory alkalosis.
104. Merck G. Reports, 1904. Tympanic congestion, erythematous patches, oedema and
sore throat.
105. Smull K, Wegria R and Leland J. Effect of sodium bicarbonate on serum salicylate level
during salicylate therapy of patients with rheumatic fever. JAMA 1944; 125: 1173 - 1175
(August 26th). Addition of sodium bicarbonate lowered salicylate blood level.
106. Coombs FS. Toxicity of salicylates. News Letter. AAF Rheumatic Fever Control
Program 1945; 2: 11 - 12 (April). Effect of sodium bicarbonate lowers salicylate blood
level by increasing urinary excretion.
107. Freund R. Arzneiexanthem nach Aspirin [drug-induced rash after Aspirin]. Münch Med
Wschr 1905; 52: 707. Fixed drug eruption with positive rechallenge.
Unsubstantiated Adverse events
Strabismus, ptosis, megaloblastic anaemia, Reye’s syndrome, agranulocytosis,
aplastic anaemia, increased saliva, tingling, teratogenicity and analgesic nephropathy.
Side Effects of Drugs, Meyler’s 1 st Edition, 1952. This covers all salicylates:
Aspirin, salicylic acid, sodium salicylate, methyl salicylate and phenyl salicylate
(Salol). The miscellaneous rashes are: maculo-papular exanthema, urticaria, fixed
drug eruption, erythema nodosum, erythema multiforme (EM), pigmentation and
haemorrhagic exanthemata.
Side Effects of Drugs 2006 15th Edition. This refers only to Aspirin.
A) Dermatological events (Type B events): the miscellaneous rashes include:
purpura, Henoch-Scönlein purpura, haemorrhagic vasculitis, erythema
multiforme, Stevens-Johnson syndrome (Stevens and Johnson, 1922), Lyell’s
syndrome, eczematous dermatitis, exanthematic eruption, erythematous,
scarlatiniform and morbilliform, bullous eruptions, pomphylox, dyshidosis-like
lesions, and fixed drug eruptions. There is supporting evidence for these skin
reactions in Litt’s Drug Eruptions Reference Manual 9 th edition: angio-oedema 1-
5%, erythema multiforme < 1%, erythema nodosum < 1%, fixed drug eruption <
1%, Stevens-Johnson Syndrome, Lyells < 1%, urticaria 1 –10%, rash 1 – 10%,