Introduction - Uppsala Monitoring Centre

Swallowing difficulties, strangulation, red face, tachycardia of 160pm, sweating, urticaria
with itching and angioneurotic oedema.
73. Pinedo Hm, Van de Putte LB and Loeliger EH. Salicylate-induced consumption
coagulopathy. Ann Rheum Dis.1973; 32: 66 - 68. Single case with liver damage and
coagulopathy with positive rechallenge.
74. Okumura H, Takayama K, Obayashi K, Ichikawa T. and Aramaki T. Chronic toxic hepatitis
caused by Aspirin. Japanese Journal of Clinical Medicine. 1965; 23(8): 1633 – 6.
75. Sheperd FJ. Remarkable case of purpuric eruption ending in gangrene apparently
caused by sodium salicylate. The New Sydenham Society; selected essays and
Monographs.1896; 367 –375. After sodium salicylate 20 grs tds for three days eruption
on body and extremities very much like urticaria became petechial, raised and indurated
leaving ulcer.
76. Broadbent. BMJ. 1887; 5 th February. Cases… temperature suddenly rises, ushering in
furious delirium and hyperpyrexia.’ Delirium, ambylopia, abdominal pain, retention of
urine, albuminuria, vertigo, vomiting and cystitis.
77. Greenhow EH. The treatment of Rheumatic fever with salicin and salicylate of soda.
Transactions of the Clinical Society of London. Spottiswoode & Co. London.1880.
‘Some symptoms of cardiac failure, calling for withdrawal of the drug.’ Headache,
deafness, tinnitus, vomiting, epistaxis, rashes, bradycardia, albuminuria, haematuria,
hallucinations, giddiness, vertigo, diarrhoea, and ambylopia.
78. Wiener Allgem Med. Zeitung. 1881; 20 th December. Took 8 grammes (about 120gr)
sodium salicylate. Headache, blind, mydriasis, deafness and somnolence. Lasted 10
hours (see 86).
79. Rushton DG. Salicylates. An International Symposium. 1963. J & A Churchill Ltd. Postmortem
oedema of larynx.
80. Gregersen JP. Occult blood in faeces of patients on oral salicylate. Ugeskr Laeg.1916;
78, 697: 1197 – 1266.
81. York CL and Fischer WJH, Jnr. New England Journal of Medicine. 1947; 237: 477.
Cardiac failure, sodium intake increased, plasma volume increased, sodium retention,
potassium loss, hypokalemia and cardiac output increased.
82. Coupland. The treatment of acute rheumatism by salicin and the salicylates.
Proceedings of the Medical Society of London. 1876; VI: 100 – 105. Twenty-four cases:
vertigo 2, headache 8, tinnitus 10, deafness 11, delirium 2, vomiting 3, abdominal pain 2,
retention of urine 3. albuminuria 1.
83. Millican. Proceedings of the Medical Society of London. 1884; VI: 126. Two out of six
cases: purpura and haematuria; albuminuria.
84. Fagge CH. Proceedings of the Medical Society of London 1884; VI: 50 – 61. Nausea
and vomiting, deafness, mental excitement, giddiness, papular rash, pustular rash,
delirium tremens, tremors and headache.
85. Sinclair R. The alkaline, salicin and salicylate of Soda treatment of acute rheumatism.
Lancet, 1880; 7 th February: 201 - 3 and 14 th February: 244 – 6 and 21 st February: 281-