Introduction - Uppsala Monitoring Centre

29. Williams JO, Mengel CE, Sullivan LW and Haq AS. Megaloblastic anaemia associated
with chronic ingestion of an analgesic. New England Journal of Medicine. 1969; 280(6):
312 – 3. Concerned aspirin salicylamide and caffeine in a single case.
30. Macklon AF, Craft AW, Thompson M and Kerr DN. Aspirin and analgesic nephropathy.
British Medical Journal. 1974; 1: 597 – 600. Aspirin rarely if ever causes analgesic
nephropathy.
31. Sussman S. Severe salicylism and acute pancreatitis. Calif. Med. 1963; 99: 29 – 32,
32. Wijnja L, Snijder JAM and Nieweg HO. Acetylacetic Acid as a cause of pancytopenia
from bone marrow damage, Lancet. 1966; 2: 768 - 70. Five patients with positive
dechallenge and in two cases positive rechallenge.
33. Rawnsley HM and Shelley WB. Salicylate ingestion and idiopathic hair loss. Lancet.
1968; 1: 567. Three out of five patients with unexplained hair loss were consistently
taking aspirin or salicylates.
34. Bertagnini C. Sulle alterationi che alcuni acidi subiscono nell’organismo animale. Il
Nuovo Cimento.Marson, G Pasero, 1855; 1: 363 - 72. Tried it on himself ‘continuous
noise in the ears and a kind of dizziness.’
35. King’s American Dispensatory by HW Felter and JU Lloyd. Ohio Valley Co. 1898.
‘ptosis, and strabismus are not uncommon results from its use’ also tingling sensation in
extremities, rapid collapse, cerebral symptoms, acute delirium, temporary amaurosis,
dimness of vision, deafness, tinnitus, pain in forehead, tremor, excess debility,
tachypnoea and renal lesions.
36. Untoward Effects of Drugs by Lewin L. Pub. George S. Davis. USA, 1883.
37. Greer HD, Ward HP, Corbin KB. Chronic Salicylic intoxication in adults. JAMA, 1965;
193, 7: 555 – 558. Five patients with chronic intoxication. Three with tremors and one
with asterixis and papilloedema. Also coma, hyperventilation, deafness and tinnitus,
dysrhythmia, hallucinations, general weakness headache, and scotomata.
38. Wigley RD. Aspirin Kidney Study. Aust New Zealand Journal of Medicine. 1973; 3: 425.
39. Anderson RJ. Asterxis as a manifestation of salicylate toxicity. Ann. Intern. Med. 1981;
95: 185 – 189. Four patients on chronic therapy had asterixis (‘liver flap’) three of them
with confusion. Positive dechallenges. Also mental confusion, tinnitus, deafness, and
semi-coma.
40. Dysart BR. Death following ingestion of 5 grammes of Acetyl Salicylic Acid. J. Allergy.
1933; 6: 504.
41. Leventhal LJ, Koritsky L. Ginsburg R and Bomalaski JB. Salicylate-induced
Rhabdomyolysis. Am. J. Emerg. Med. 1989; 7: 409 – 410.
42. Mortimer E.A. and Lepow M.L. Varicella with hypoglycaemia possibly due to Aspirin.
Am. J. Dis. Child. 1962; 103: 583. Four fatal cases of varicella with hypoglycaemia
following large amounts of salicylates in three of them (80, 80 and 160mgm 3 – 4 times
a day respectively); now thought to be Reye’s syndrome.
43. Widal F, Abrami P, Lermoyer J. Anaphylaxis et idiosyncrasie. Presse Médicale 1922; 30:
189-193,. First description of aspirin idiosyncrasy-asthma-nasal polyposis syndrome.