Introduction - Uppsala Monitoring Centre

282. Headache, giddiness, tinnitus, sleeplessness, delirium, disagreeable taste, cardiac
depression, perspiration, depression, haemorrhagic erosions of the mucous membrane
of the stomach, fever, dimness of vision, vomiting, deafness and unconsciousness.
86. Owen I, Proceedings of the Medical Society of London. 1884; .VI: 61- 73. Single case:
headache, transient blindness, somnolence, mydriasis, and deafness after 120 gr
sodium salicylate.
87. Witthauer. Die Heilkunde. 1899; April. ‘It can be given without deranging the
stomach…. Ringing in the ears is hardly ever observed with aspirin.’
88. Leveson I. Aspirin Poisoning. BMJ. 1949; September 17 th: 628 - 30. Feeling of gastric
discomfort, epigastric pain, nausea and vomiting, facial oedema, sweating,
restlessness, hallucinations, coma, subnormal temperature, shock, low blood pressure,
albuminuria, pyrexia, dehydration, convulsions, stertorous respirations, myoclonic
twitching, and flushing.
89. Sable HZ. Toxic reactions following salicylate therapy. Can. M.A.J. 1945; Feb 52: 153
– 159. Dimness of vision, thirst, dehydration, bradycardia, hypotension, oliguria, heart
failure, granulocytopenia, dyspnoea, gastric retention, maculopapular rash, pustular
acne, convulsions, psychosis, irritability, aphonia, dysphagia, asthma, oedema glottis,
angio-neurotic oedema, purpura, diarrhoea, perspiration, depression of bone marrow
function, albuminuria, headache, dizziness, tinnitus, impaired hearing, weakness,
collapse, delirium, subnormal temperature, nausea and vomiting.
90. Shokhoff, C., and Lieberman D. L., Hypersensitiveness to acetyl salicylic acid
expressed by angina pectoris syndrome, with and without urticaria. J. Allergy, S. Louis.
1933; 4: 506 – 512.
91. Dukes MNG. Antipyretic-analgesics. In: Meyler’s Side Effects of Drugs. 11 th edition.
1988; 156 – 69. Severe blood dyscrasias.
92. Quincke H. Zur Kenntniss der Salcylsäure Wirkung, Berl. klin. Wchnschr. 1882; 19: 709
– 711.
93. J. La Med. Soc. 1961; 113: 292. Single case: anaphylactic shock, urticaria, and itching.
94. Med Letter. 1964; 6 (14). (MRL L5.325) Leucopenia mentioned.
95. J. Indian Med.Ass. 1956; 27: 19. Single case: itching, bullous exanthema, urticaria and
angioneurotic oedema.
96. Notes, short comments and answers to correspondents. Lancet, 1905; November,
1518. Gastric pain, vomiting, giddiness, angio-oedema, sweating, epistaxis, and
erythematous rash.
97. Tirard Nestor, Some clinical observations with new remedies. Lancet, 1905; 73: 83 - 4,.
Dyspeptic symptoms, diarrhoea, and perspiration.
98. Douthwaite AH and Lintott GAM. Gastroscopic observation of the effect of aspirin and
certain other substances on the stomach. Lancet, 1938; ii: 1222 - 5. Gastric
submucosal haemorrhage.
99. Fernandez-Rivas, Miranda I. Unusual NSAID hypersensitivity. Allergy, 2002; 57: 183 –
184,. Reactions 2002; 899: 13. Conjunctivitis with positive rechallenge also with