Introduction - Uppsala Monitoring Centre

of hearing, and perspiration.
13. Riess, Berliner Klinische Wochenscrift. 1877, p29. Dimness of vision and flickering
before the eyes.
14. Graham JDP and Parker WA. The toxic manifestations of sodium salicylate therapy.
Quart. J. Med. 1948; 41, 153. Single case of pulmonary oedema without details.
15. Hoffman WS, Pomeranc M, Volini IF and Nobe C. Treatment of acute rheumatic fever
with aspirin. Amer. J. Med. 1949; 6,. The prothrombin concentration was only slightly
affected by aspirin therapy. Tinnitus, partial deafness, pounding in the head, nausea and
vomiting, and feeling of intoxication. Bicarbonate reduces plasma salicylate levels.
16. Goltdammer, Zur inneren Anwendung der Salicylsäure. Berliner Klinische Wochenscrift,
1876, p47. Several cases of collapse, unpleasant taste, burning and discomfort in mouth,
vomiting, pea-size ulcers in stomach, sweating, restlessness, insomnia, fall in
temperature, diarrhoea, and general exhaustion after 5 gramme doses.
17. Sollman T. A Manual of Pharmacology and its Application to Therapeutics and
Toxicology. 1948, p537. Dehydration, polyuria, oliguria and nephrosis.
19. Prickman LE and Buchstein HF. Hypersensitivity to acetyl-salicylic acid (Aspirin) JAMA.
1937; 108, 445. Cases of asthma, angioneurotic oedema, urticaria, vasomotor rhinitis,
purpura, abdominal cramps and salivation.
20. Wien Klinische Wochenschrift. 1948; 60, 175. Shock, coma and peritoneal irritation.
21. Davison F. R. Synopsis of Materia Medica, Toxicology and Pharmacology, St Louis,
1946. p325. Deafness and blindness.
22. Manchester RC. Rheumatic fever in naval enlisted personnel: III The physiological and
toxic effects of intensive salicylate therapy in cases of acute rheumatic fever. J. Amer.
Med. Ass. 1946; 131, 209. Hyperpyrexia, renal pain, delirium, nausea and vomiting,
deafness, tinnitus, vertigo, sweating, delirium, dyspnoea, rashes, hallucinations,
hypoprothrombinemia, insomnia, and hypernoea.
23. Staff meeting. Proc. Mayo Clin. 1947; 22, 391-3. Single case of convulsions and coma
with a positive rechallenge as part of drug allergy.
24. Krasnoff SO and Bernstein M. Acetylsalicylic acid poisoning. JAMA. 1947; 135, 712.
Single fatal case with confusion, tachycardia, deafness, tinnitus, difficult breathing,
incoherent, restlessness, flushed, petechiae, BP 96/60 – 170/90mmHg., Temp 107° F
and coma.
25. Cochran J.B. and Watson R.D. Mild Cushing’s syndrome due to Aspirin. British Medical
Journal. 1950; II: 1411-3. Single case: Cushing‘s syndrome with glycosuria, acne, water
and salt retention.
26. Amer. J. Med Sci. 1949; 217: 256. Acidosis and respiratory alkalosis.
27. Hirschberg. Mittheilung über ein Fall von Nebenwirkung des Aspirin. Deutsche Med.
Wochenschr. 1902; 28: 416. Anaphylactoid reaction to Aspirin.
28. Sarwer-Foner GJ and Morrison GH. Acute toxic psychosis due to acetyl-salicylic acid.
Canadian Services Medical Journal. 1955; 11(9): 599-606. Single case report of visual
and auditory hallucinations with paranoia.