MAGICAL MEDICINE: HOW TO MAKE AN ILLNESS ... - Invest in ME

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Hyde; The Nightingale Press, Ottawa, Canada 1992). Other references to vasculopathy in ME/CFS in the
same textbook include:
page 42 (Chapter 5 / BM Hyde): ʺWe routinely observe patients with severely cold extremities and a visible line
demarcating the cold from the area of normal skin temperature. The fact that the loss of normal blood flow may be
persistent has been indicated by Gilliam (1938)ʺ
page 62: ʺPatients will complain of severe blanching of their extremities, nose, ears, lower arms and hands as well as
lower legs and feet. Observation will often reveal a blanched clearly demarcated line separating warm from icy cold
tissue. The whitened extremities may persist for hours and can be extremely painfulʺ
page 70: ʺThe haemorrhages are mostly around small vessels, but some are also to be seen in the free tissueʺ
page 73: Hyde discusses the occurrence of Raynaudʹs Disease in ME/CFS: “This is common in ME/CFS. These
acute Raynaudʹs Disease changes are visibleʺ
page 89 (Chapter 8 / John Richardson): “A liver biopsy showed a vasculitis of the liverʺ
page 91: ʺLiver Function Tests are sometimes abnormal and signify a vasculitis of the liverʺ
page 250 (Chapter 23 / Jay Goldstein): ʺSPECT scanning may justify vasodilator therapy with calcium channel
blockersʺ
page 286 (Chapter 28 / EG Dowsett): ʺME is a multisystem syndrome including nervous, cardiovascular, endocrine
and other involvement. Symptoms and Signs (table 2): Vasculitic skin lesions, autonomic dysfunction, especially
circulation and thermoregulationʺ
page 376: (Chapter 42: Hyde and Jain: Cardiac and Cardiovascular Aspects of ME/CFS): reference is made
to ʺfrequent vasomotor abnormalitiesʺ
page 377: ʺvasomotor disturbances were almost constant findings, with coldness and cyanosis. It was the impression
of most observers that a generalised disturbance of vasomotor control occurred in these patientsʺ
page 377: “Findings included sinus tachycardia, abnormal T waves in two or more leads (and) prolongation of Q‐T
interval”
page 377: “Myocarditis in the acute phase: the heart rate was accelerated (and) tachycardia was considered to be a
diagnostic feature. In four cases there was a persistent rise in blood pressure (which) slowly lowered over a period of
many months”
page 378: “Cardiovascular symptoms: angina‐like pain; vascular headache; orthostatic hypertension; oedema;
dyspnoea; transient hypertension” (note that on page 42, Hyde states about blood pressure regulation: “Some
seem to be unable to adjust blood pressure with body activity, resulting in high blood pressure on modest
activity and very low pressure when reclining”)
page 378: referring to Professor Peter Behan’s CIBA lecture in 1988: “using SPECT scan techniques, his team
was regularly able to demonstrate micro‐capillary perfusion defects in the cardiac muscle of ME patients”
page 380: “These chronic ME/CFS patients complain of severe chest pain and shortness of breath as if
suddenly stopped by an invisible barrier”