MAGICAL MEDICINE: HOW TO MAKE AN ILLNESS ... - Invest in ME

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fatigue, case‐patients were significantly more likely to have had palpable splenomegaly noted in their medical records”
(Gary P Holmes et al. JAMA 1 st May 1987:257:17:2297‐2302).
1987
“22% had mildly deranged liver function tests” (BD Calder et al. JRCGP 1987:37:11‐14).
1988
“There may be splenomegaly or hepatomegaly” (M. Fisher Portwood. Nurse Practitioner 1988:13:2:11‐23).
1991
“Enlargement of the spleen and liver is also not unusual” (SA Daugherty, BE Henry, DL Peterson et al. Reviews
of Infectious Diseases 1991:13 (Suppl 1):S39‐44).
1993
Up to 20% of (ME)CFS patients were noted to have hepatomegaly and splenomegaly (Anthony L Komaroff.
CFS: CIBA Foundation Symposium 173: John Wiley, Chichester, 1993:43‐61).
1993
“A significant number of patients with ME have exactly the same liver abnormality…that is seen in Gilbert’s
syndrome” (Charles Shepherd, Perspectives, Medical Matters: September 1993: iv).
1997
“CFIDS patients have been reported to have multiple (physical) findings (including) hepatomegaly” (CM Jorge, PJ
Goodnick. Psychiatric Annals 1997:27:5:365‐366).
2000
“Hepatitis was found in 13.6%” (Fred Friedberg et al. J psychsom Res 2000:48:59‐68).
2001
“Animals subjected to both chemicals and stress exhibited dramatic increase in blood brain barrier permeability.
Histological changes were also present in the liver and were particularly severe when the combination was used” (MB
Abou‐Donia. Presented at The Alison Hunter Memorial Foundation Third International Clinical and
Scientific Conference on ME, 1 st ‐2 nd December 2001, Sydney, Australia).
Documented respiratory abnormalities in ME/CFS
1989
Payne and Sloan noted exertional dyspnoea in ME/CFS, with lung function studies showing a reduced
forced expiratory flow (70% of the predicted value) and abnormalities of small airways and gas transport
that might lead to reduced exercise tolerance shown in these patients (Ann Intern Med 1989:111:10:860).