IARC MONOGRAPHS ON THE EVALUATION OF CARCINOGENIC ...

Table 8. Genetic and related effects of aristolochic acid (AA)
Test system
Result a
Without
exogenous
metabolic
system
With
exogenous
metabolic
system
Compound,
dose (LED or HID) b
Reference
Escherichia coli PQ37 SOS repair induction + + c
AA plant extract, Kevekordes et al.
0.38 μg/assay
(1999)
Escherichia coli PQ37 SOS repair induction + + c
AAI, 0.17 μg/assay Kevekordes et al.
(1999)
Escherichia coli PQ37 SOS repair induction + (+) c
AAII, 0.16 μg/assay Kevekordes et al.
(1999)
Salmonella typhimurium TM677, forward mutation, hprt locus in vitro + NT AAI, 8.5 Pezzuto et al. (1988)
Salmonella typhimurium TA100, TA1537, reverse mutation + + AA mixture, 50 μg/plate Robisch et al. (1982)
Salmonella typhimurium TA1535, TA1538, TA98, reverse mutation – – AA mixture, 200 μg/plate Robisch et al. (1982)
Salmonella typhimurium TA100, TA1537, reverse mutation + + AAI, 100 μg/plate Schmeiser et al. (1984)
Salmonella typhimurium TA100, TA1537, reverse mutation – + Aristolactam I and
aristolactam II, 50 μg/plate
Schmeiser et al. (1986)
Salmonella typhimurium TA100, TA102, TA1537, reverse mutation + NT AAI, 100 μg/plate Pezzuto et al. (1988)
Salmonella typhimurium TA98, YG1020, YG1021, reverse mutation (+) NT AAI, 170 μg/plate Götzl & Schimmer
(1993)
Salmonella typhimurium TA98, YG1020, YG1021, reverse mutation (+) NT AAII, 78 μg/plate Götzl & Schimmer
(1993)
Salmonella typhimurium YG1024, reverse mutation + NT AAI, 34 μg/plate Götzl & Schimmer
(1993)
Salmonella typhimurium YG1024, reverse mutation + NT AAII, 31 μg/plate Götzl & Schimmer
(1993)
Salmonella typhimurium TA100NR, reverse mutation – – AAI, 200 μg/plate Schmeiser et al. (1984)
Salmonella typhimurium TA100NR, TA98NR, reverse mutation – NT AAI, 200 μg/plate Pezzuto et al. (1988)
Salmonella typhimurium TA100, YG1025, YG 1026, YG 1029, + NT AAI and AAII, 34 μg/plate Götzl & Schimmer
reverse mutation
(1993)
SOME TRADITIONAL HERBAL MEDICINES 113