IARC MONOGRAPHS ON THE EVALUATION OF CARCINOGENIC ...

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yellow bark and a wood with broad, whitish rays arranged radially and a distinct, yellowish brown cambium ring. Its odour is aromatic and characteristic and it has a bitter taste. 1.1.2 Aristolochia manshuriensis The dried stem of A. manshuriensis (see Figure 3) is called Guan Mu Tong (Caulis Aristolochiae manshuriensis in Latin and commonly Manchurian Dutchman’s pipe stem). Figure 3. Aristolochia manshuriensis From Qian (1996) 1, fruit twig; 2, flower; 3, transverse section SOME TRADITIONAL HERBAL MEDICINES 73 The stem is twined and woody, grey and striated, from 6 to 14 m long. Its branches are dark purple, with whitish villi. Leaves are either petioled, entire or ovate-cordate and are 15–29 cm long and 13–28 cm wide with a whitish down on each side. Petioles are 6–8 cm long. Flowers are axillary, single and peduncled; the apex is disc-shaped, with a
74 diameter of 4–6 cm or more, lobed, wide triangular and greenish outside; the lower part is tubular, 5–7 cm long, 1.5–2.5 cm in diameter and pink outside. Peduncles are drooping, with an ovate cordate, whitish, villous, sessile, greenish bract, 1 cm long. Six stamens adhibit to the outside of the stigma in pairs; they are inferior to the ovary, cylindrical, angular, whitish villi and 1–2 cm long. Capsules are cylindrical, dark brown, 9–10 cm long and 3–4 cm in diameter and burst into six valves when ripe. Seeds are numerous in each cell and cordate to triangular-shaped, with no winged margin. The dried stem is long, cylindrical, slightly twisted, 1–2 m long and 1–6 cm in diameter. Externally, it is greyish yellow or brownish yellow, with shallow longitudinal grooves and has adhering remains of brown patches of coarse bark. Nodes are slightly swollen, with a branch scar. The stem is light and hard, not easily broken, but when fractured shows a narrow yellow or pale yellow bark, and broad wood having vessels arranged in many rings, with radial rays and indistinct pith. It has a slight odour and a bitter taste and gives off a smell like camphor when the remains of the coarse bark are rubbed. 1.1.3 Aristolochia fangchi The dried root of A. fangchi (see Figure 4) is named Guang Fang Ji (Radix Aristolochiae fangchi in Latin and commonly southern fangchi root). A. fangchi is a perennial climbing vine with crassitudinous roots. The stem is slender, greyish brown, with brownish villi and is 3–4 m long. The leaves are either petioled, entire, oblong or ovate-shaped, with grey whitish villi when young, and are 3–11 cm long and 2–6 cm wide. The petiole is 1–4 cm long. The perianth is canister-shaped, purple with yellowish spots and 2–3 cm long. Six stamens adhibit to the outside of the trilobed stigma. The capsules have numerous seeds. The plant grows in valleys along streams and in thickets and blooms from May to June. The dried root is cylindrical or semi-cylindrical, slightly curved, 6–18 cm long and 1.5–4.5 cm in diameter. Externally it is greyish brown, rough and longitudinally wrinkled; the peeled stems are yellowish. The root is heavy and compact and is broken with difficulty; when fractured, the inside is starchy, exhibiting alternately greyish brown and whitish radial lines. It is odourless with a bitter taste. 1.1.4 Aristolochia clematitis IARC MONOGRAPHS VOLUME 82 The medicinal parts of birthwort (A. clematitis) are the aerial portion (when in blossom) and the root. The plant has dirty yellow flowers, usually in axillary groups of seven. The perigone forms a straight tube, which is bulbous beneath and has a linguiform, oblong-ovate, obtuse border. There are six stamens, the style is upward-growing , and the stigma is six-lobed. The flower briefly traps insects that pollinate it. The fruit is a globose, pear-shaped capsule. The plant grows to a height of 30–100 cm. The stem is erect, simple, grooved and glabrous. The leaves are alternate, long-petioled, cordate-reniform, yellow-green, with prominent ribs. The plant has a fruit-like fragrance and is poiso-
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WORLD HEALTH ORGANIZATION INTERNATI
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IARC MONOGRAPHS In 1969, the Intern
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iv IARC MONOGRAPHS VOLUME 82 3.2 Th
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vi IARC MONOGRAPHS VOLUME 82 SOME M
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IARC WORKING GROUP ON THE EVALUATIO
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PARTICIPANTS 5 Observer, representi
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PREAMBLE
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10 IARC MONOGRAPHS VOLUME 82 plasms
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12 IARC MONOGRAPHS VOLUME 82 collec
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14 agents present. For processes, i
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16 IARC MONOGRAPHS VOLUME 82 Finall
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18 IARC MONOGRAPHS VOLUME 82 and mi
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20 IARC MONOGRAPHS VOLUME 82 (c) St
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Page 40 and 41: GENERAL REMARKS ON THE SUBSTANCES C
Page 42 and 43: GENERAL REMARKS ON THE SUBSTANCES C
Page 44: GENERAL REMARKS ON THE SUBSTANCES C
Page 48: SOME TRADITIONAL HERBAL MEDICINES
Page 51 and 52: 44 which may include, for example,
Page 53 and 54: 46 2. Use of Traditional Herbal Med
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Page 57 and 58: 50 IARC MONOGRAPHS VOLUME 82 Table
Page 59 and 60: 52 3.2.1 Definition of herbal medic
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Page 65 and 66: 58 3.3.2 Germany (see Kraft, 1999;
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Page 75 and 76: 68 IARC MONOGRAPHS VOLUME 82 Jellin
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Page 83 and 84: 76 1.2 Use 1.2.1 Aristolochia conto
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Page 87 and 88: 80 1.6.2 Structural and molecular f
Page 89 and 90: 82 chromatographic separation with
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Page 93 and 94: 86 IARC MONOGRAPHS VOLUME 82 A bila
Page 95 and 96: 88 received distilled water. The an
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Page 99 and 100: 92 varied from undetectable (< 0.02
Page 101 and 102: 94 lochic acids enhanced immune res
Page 103 and 104: 96 4.4 Genetic and related effects
Page 105 and 106: Table 3 (contd) Details of study DN
Page 107 and 108: Table 4. DNA adduct formation with
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Page 111 and 112: Table 5 (contd) Species Treatment I
Page 113 and 114: Table 6. DNA adduct formation by ar
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Page 119 and 120: Table 7. Polymerase action on arist
Page 121 and 122: Table 8 (contd) Test system Drosoph
Page 123 and 124: 116 of the forestomach and lung of
Page 125 and 126: 118 lochic acid II (three metabolit
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124 IARC MONOGRAPHS VOLUME 82 Nishi
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126 IARC MONOGRAPHS VOLUME 82 Schme
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128 IARC MONOGRAPHS VOLUME 82 Yang,
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130 Figure 1. Morinda officinalis H
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132 1.3.2 Morinda officinalis A num
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134 by Soxhlet extraction with ethy
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136 2.1 Case-control studies 2.1.1
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138 3. Studies of Cancer in Experim
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140 1,3-Dihydroxy-2-hydroxymethylan
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142 4.3 Reproductive and developmen
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Table 1 (contd) Test system Result
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146 5.1 Exposure data 5. Summary of
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148 IARC MONOGRAPHS VOLUME 82 Brigg
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150 IARC MONOGRAPHS VOLUME 82 Nusko
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D. SENECIO SPECIES AND RIDDELLIINE
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metry (Witte et al., 1992). Thin-la
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sex were killed after a seven-week
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4.2.2 Experimental systems SOME TRA
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Table 1. Genetic and related effect
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Riddelliine induced unscheduled DNA
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5.3 Animal carcinogenicity data In
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SOME TRADITIONAL HERBAL MEDICINES 1
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SOME MYCOTOXINS
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172 Aflatoxin G 1 IARC MONOGRAPHS V
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174 IARC MONOGRAPHS VOLUME 82 Table
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Table 2 (contd) Method no. Aflatoxi
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178 indicates that A. flavus and A.
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Table 4. Occurrence of aflatoxin B1
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182 IARC MONOGRAPHS VOLUME 82 aflat
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Table 6. Co-occurrence of aflatoxin
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186 IARC MONOGRAPHS VOLUME 82 Figur
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188 1.4 International exposure esti
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190 (c) Impact of establishing maxi
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192 IARC MONOGRAPHS VOLUME 82 used
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Table 10 (contd) Reference Area Uni
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198 were collapsed into a conventio
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Table 11 (contd) Reference Area Stu
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202 IARC MONOGRAPHS VOLUME 82 histo
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204 IARC MONOGRAPHS VOLUME 82 resid
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Table 12. Summary of principal case
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208 IARC MONOGRAPHS VOLUME 82 disea
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210 3. Studies of Cancer in Experim
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212 IARC MONOGRAPHS VOLUME 82 diet
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214 3.4 Administration with known c
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216 IARC MONOGRAPHS VOLUME 82 The 8
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218 observed in rat liver slices, a
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222 IARC MONOGRAPHS VOLUME 82 an α
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224 (mainly hepatocellular carcinom
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226 IARC MONOGRAPHS VOLUME 82 but i
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228 lordosis and reduction in conce
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232 IARC MONOGRAPHS VOLUME 82 sampl
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234 In eight subjects (four from Ho
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240 IARC MONOGRAPHS VOLUME 82 anima
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242 difference between the two stud
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244 IARC MONOGRAPHS VOLUME 82 HBV-t
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246 In a large cohort study in Shan
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248 experimental data in showing th
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250 IARC MONOGRAPHS VOLUME 82 Ander
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252 IARC MONOGRAPHS VOLUME 82 Buetl
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254 IARC MONOGRAPHS VOLUME 82 Denis
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256 IARC MONOGRAPHS VOLUME 82 Galla
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258 IARC MONOGRAPHS VOLUME 82 Heino
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260 IARC MONOGRAPHS VOLUME 82 Jalon
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262 IARC MONOGRAPHS VOLUME 82 Kirk,
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264 IARC MONOGRAPHS VOLUME 82 Lunn,
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266 IARC MONOGRAPHS VOLUME 82 Olubu
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268 IARC MONOGRAPHS VOLUME 82 Roll,
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270 IARC MONOGRAPHS VOLUME 82 Stett
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272 IARC MONOGRAPHS VOLUME 82 Verge
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274 IARC MONOGRAPHS VOLUME 82 Yang,
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Table 1. IARC evaluations Previous
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278 kernels and in less than 0.1% o
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280 2.5.3 Cottonseed A. flavus is a
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294 IARC MONOGRAPHS VOLUME 82 8. Re
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296 IARC MONOGRAPHS VOLUME 82 Guo,
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298 IARC MONOGRAPHS VOLUME 82 Marti
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300 IARC MONOGRAPHS VOLUME 82 Sharm
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302 (d ) Solubility: Soluble in wat
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304 1.4 Occurrence Fumonisins have
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306 Table 1 (contd) IARC MONOGRAPHS
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308 (c) Formation in commodities ot
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312 IARC MONOGRAPHS VOLUME 82 3.1 O
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314 3.2.2 Rat IARC MONOGRAPHS VOLUM
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316 with NDEA and fumonisin B 1, wh
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318 IARC MONOGRAPHS VOLUME 82 In pi
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Figure 2. Allometric relationship b
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322 IARC MONOGRAPHS VOLUME 82 obser
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324 IARC MONOGRAPHS VOLUME 82 Hepat
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326 4.2.3 Related studies IARC MONO
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328 4.3.2 Experimental systems IARC
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330 and litters on postnatal day 21
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Table 4. Genetic and related effect
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334 IARC MONOGRAPHS VOLUME 82 The f
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336 IARC MONOGRAPHS VOLUME 82 (d )
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338 IARC MONOGRAPHS VOLUME 82 treat
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340 4.5.2 Interference with fatty a
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344 5.2 Human carcinogenicity data
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346 IARC MONOGRAPHS VOLUME 82 Alber
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348 IARC MONOGRAPHS VOLUME 82 Chamb
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350 IARC MONOGRAPHS VOLUME 82 Floss
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352 IARC MONOGRAPHS VOLUME 82 Hiroo
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354 IARC MONOGRAPHS VOLUME 82 Lee,
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356 IARC MONOGRAPHS VOLUME 82 Mobio
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358 IARC MONOGRAPHS VOLUME 82 Prelu
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360 IARC MONOGRAPHS VOLUME 82 Savar
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362 IARC MONOGRAPHS VOLUME 82 Steve
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364 IARC MONOGRAPHS VOLUME 82 Flett
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366 IARC MONOGRAPHS VOLUME 82 Yu, C
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368 disulfide, carbon tetrachloride
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Table 1 (contd) Sample matrix Sampl
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Table 3. Naphthalene production (th
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374 1.4 Occurrence 1.4.1 Natural oc
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Table 5. Occupational exposure to n
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378 water assuming a water concentr
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380 (Scheepers & Bos, 1992). The av
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382 (d ) Biodegradation Studies on
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386 3.2 Inhalation exposure 3.2.1 M
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388 3.3.2 Rat Ten BD I and BD III r
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Figure 1. Main metabolic pathways o
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392 IARC MONOGRAPHS VOLUME 82 and t
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394 IARC MONOGRAPHS VOLUME 82 and 1
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396 IARC MONOGRAPHS VOLUME 82 1-240
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398 IARC MONOGRAPHS VOLUME 82 Perfu
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400 Siegel and Wason (1986) reviewe
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402 IARC MONOGRAPHS VOLUME 82 liver
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404 IARC MONOGRAPHS VOLUME 82 to id
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406 IARC MONOGRAPHS VOLUME 82 Alkal
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408 hyperplasia, atrophy, chronic i
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410 had deficient glucose-6-phospha
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Table 10. Genetic and related effec
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Table 10 (contd) Test system Micron
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416 assay with or without metabolic
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418 There is some evidence of devel
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420 IARC MONOGRAPHS VOLUME 82 Bjør
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422 IARC MONOGRAPHS VOLUME 82 Conkl
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424 IARC MONOGRAPHS VOLUME 82 Envir
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426 IARC MONOGRAPHS VOLUME 82 Ho, C
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428 IARC MONOGRAPHS VOLUME 82 Lynch
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430 IARC MONOGRAPHS VOLUME 82 O’B
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432 IARC MONOGRAPHS VOLUME 82 Schee
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434 IARC MONOGRAPHS VOLUME 82 Versc
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STYRENE This substance was consider
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EPA Method 8260B can be used to det
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Styrene is produced mainly by catal
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STYRENE 443 Table 3. Use patterns f
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STYRENE 445 most samples taken from
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STYRENE 447 successive layers of ch
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Table 4 (contd) Country and year of
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Table 5. Biological monitoring of o
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STYRENE 453 Since 1990, the long-te
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same products resulted in exposures
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STYRENE 457 Ambient air monitoring
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200 μg/kg, although 77% of the foo
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Table 8 (contd) Country or region Y
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2.1 Case reports 2. Studies of Canc
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Table 10 (contd) Reference (country
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Table 10 (contd) Reference (country
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STYRENE 469 (95% CI, 1.4-5.2; 10 de
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who had been employed in 1964-70 (t
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elationship for styrene became nega
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atio, 4.4; 95% CI, 1.1-17 in multip
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controls versus 32/32 treated). No
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3.4 Intraperitoneal administration
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Figure 1. Main metabolic pathways f
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STYRENE 483 a maximum and averaged
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(b) Distribution STYRENE 485 An ear
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STYRENE 487 rats with phenobarbital
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STYRENE 489 gavage (100-350 mg/kg b
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CYP2E1 and CYP2F2) inhibited nasal
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model indicated that absorbed styre
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female workers in the glass fibre-r
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STYRENE 497 continuously for seven
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STYRENE 499 exposure concentrations
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STYRENE 501 The frequency of sponta
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STYRENE 503 groups. Only minor gene
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concentrations of styrene in air we
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Table 12. Cytogenetic studies in ly
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Table 13. Genetic and related effec
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(b) Experimental systems (see Table
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STYRENE 515 styrene 7,8-oxide. Joha
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Styrene 7,8-oxide can bind to DNA w
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STYRENE 519 a small and non-signifi
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STYRENE 521 and immune systems, liv
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STYRENE 523 Artuso, M., Angotzi, G.
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STYRENE 525 Brugnone, F., Perbellin
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STYRENE 527 Coccini, T., Maestri, L
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STYRENE 529 Edling, C., Anundi, H.,
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STYRENE 531 Gobba, F., Galassi, C.,
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STYRENE 533 Horvath, E., Pongracz,
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STYRENE 535 logical Study and the I
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STYRENE 537 Linhart, I., Gut, I.,
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STYRENE 539 Miller, S.L., Branoff,
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STYRENE 541 Newhook, R. & Caldwell,
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STYRENE 543 Pryor, G.T., Rebert, C.
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STYRENE 545 Sielken, R.L. & Valdez-
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STYRENE 547 Tsuda, S., Matsusaka, N
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STYRENE 549 Boffetta, P. (1996b) Ex
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Agent SUMMARY OF FINAL EVALUATIONS
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554 IARC MONOGRAPHS VOLUME 82 DGAL:
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556 IARC MONOGRAPHS VOLUME 82 PMTDI
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558 IARC MONOGRAPHS VOLUME 82 Aldri
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560 IARC MONOGRAPHS VOLUME 82 Benz[
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562 β-Butyrolactone 11, 225 (1976)
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564 IARC MONOGRAPHS VOLUME 82 Chlor
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566 Cyproterone acetate 72, 49 (199
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568 IARC MONOGRAPHS VOLUME 82 Diepo
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570 Ethionamide 13, 83 (1977); Supp
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572 IARC MONOGRAPHS VOLUME 82 Haema
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574 L Lasiocarpine 10, 281 (1976);
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576 IARC MONOGRAPHS VOLUME 82 Methy
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578 IARC MONOGRAPHS VOLUME 82 Nicke
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580 O Ochratoxin A 10, 191 (1976);
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582 IARC MONOGRAPHS VOLUME 82 Polyb
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584 Rhodamine 6G 16, 233 (1978); Su
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586 Sulfafurazole 24, 275 (1980); S
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588 1,1,1-Trichloroethane 20, 515 (
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590 Y Yellow AB 8, 279 (1975); Supp
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Volume 31 Some Food Additives, Feed
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