IARC MONOGRAPHS ON THE EVALUATION OF CARCINOGENIC ...

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Table 5. Biological monitoring of occupational exposure to styrene in the glass fibre-reinforced plastics industry Country and year of survey No. of plants Job/task No. of samples Concentrations at end of shift Reference Mandelic acid in urine (mg/g creatinine) Canada (Quebec) 3 Chopper gun operation 7 [980] [980] NR Painting (gel coat) 9 [750] [310] Laminating (rolling) 18 [1690] [605] Foreman 8 [350] [470] Cutting 11 [320] [380] Warehouse worker 19 [70] [70] Finishing 31 [110] [120] Mould repair 8 [30] [50] Germany NR 4 Laminating boats, pipes, or containers Phenylglyoxylic acid in urine (mg/g creatinine) Styrene in blood (mg/L) Mean SD Mean SD Mean SD 36 210 (10–3640) a 190 (10–870) a 0.39 (0.04–4.82) a Italy 4 Refrigerating containers 6 493 434 121 96 0.32 0.42 NR Flooring tiles 6 428 248 72 22 0.42 0.16 Fibre-glass canoes 5 270 54 62 24 0.52 0.32 Fibre-glass tanks 3 323 129 132 41 NR Italy 118 Hand lamination 2386 450 GM 2.75 GSD 1978–90 Spray lamination 250 211 GM 3.3 GSD Rolling 63 182 GM 3.08 GSD Semi-automatic process operation 121 154 GM 259 GSD Non-process work 762 94 GM 3.27 GSD Switzerland NR 10 NR 88 1004 1207 339 360 United Kingdom 1979 1 Boat industry 27 [780] 555 [0.72] [0.43] SD, standard deviation; NR, not reported; GM, geometric mean; GSD, geometric standard deviation a Median (range) in mg/L Truchon et al. (1992) Triebig et al. (1989) Bartolucci et al. (1986) Galassi et al. (1993) Guillemin et al. (1982) Cherry et al. (1980) STYRENE 451
452 IARC MONOGRAPHS VOLUME 82 study was an in-depth industrial hygiene survey of styrene and other workplace exposures. A total of 141 workplaces with 2600 workers were inspected, and in 50 of these workplaces, a total of 379 workers were monitored over a full work shift. Exposures were sampled by a charcoal tube method with personal sampling pumps, and in addition with passive organic vapour dosimeters, and by analysis of the urine of 327 workers (85% of the study population) for mandelic acid. The focus of the study was on large open-mould spray-up/lay-up operations. Styrene exposures at these processes ranged from 0.2 to 288 ppm [0.85–971 mg/m 3 ] TWA for eight hours; the 8-h TWA arithmetic mean and the median for these sample results were 43.0 ppm [183 mg/m 3 ] and 34.0 ppm [145 mg/m 3 ], respectively. In a comparison of worker exposure levels by industry, the Cal/OSHA study showed that the geometric mean exposure levels were highest in tub/shower manufacturing facilities (53.6 ppm [228 mg/m 3 ]), followed by camper manufacturing (41.0 ppm [175 mg/m 3 ]), boat manufacturing (29.1 ppm [124 mg/m 3 ]), spa manufacturing (25.8 ppm [110 mg/m 3 ]), miscellaneous manufacturing (22.0 ppm [94 mg/m 3 ]), and tank manufacturing facilities (12.7 ppm [54 mg/m 3 ]). Operations ranked according to percentage of styrene exposures above 100 ppm [430 mg/m 3 ] as an 8-h TWA were: tub/shower manufacturing (19%), spa manufacturing (11%), camper manufacturing (6%), miscellaneous plastics manufacturing (4%) and boat and tank manufacturing (none). Styrene exposures were measured for 82 Dutch workers at four plants where unsaturated polyester resins were applied to moulds in the production of glass fibre-reinforced plastics (Geuskens et al., 1992). The study considered three resin application categories: filament winding techniques; hand laminating or spraying using more than 25 kg resin every 4 h; hand laminating using less than 25 kg resin per 4 h; workers who were in the production area but did not come into direct contact with styrene were the control group. The geometric mean 8-h TWA concentrations for the four plants ranged from 11 to 49 ppm [47–209 mg/m 3 ] for the workers who came into direct contact with styrene and from 5 to 16 ppm [21–68 mg/m 3 ] for those who were in the production area but had no contact with styrene. Wong et al. (1994) followed 15 826 American workers in the reinforced plastics industry who had worked in areas with exposure to styrene for at least six months between 1948 and 1977. Using estimates of exposure based on current (around 1980) measurements and a historical assessment of work practices, plant design, process design and occupational hygiene factors, they divided their cohort into strata by cumulative styrene exposure. Approximately 23% of the workers had estimated cumulative exposures exceeding 100 ppm–years. The estimated average exposure among members of this group was 298 ppm–years. The Norwegian National Institute of Occupational Health reviewed a collection of more than 7000 styrene concentration measurements taken in 234 reinforced-plastics production companies in Norway during the years 1972 through 1996 (Lenvik et al., 1999). Of these plants, 124 (accounting for 60.2% of the measurements) produced boats, 65 (accounting for 30.2%) produced small items, five (accounting for 3.4%) produced car body parts and another 40 (accounting for 6.2%) produced miscellaneous items.
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WORLD HEALTH ORGANIZATION INTERNATI
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IARC MONOGRAPHS In 1969, the Intern
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iv IARC MONOGRAPHS VOLUME 82 3.2 Th
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vi IARC MONOGRAPHS VOLUME 82 SOME M
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IARC WORKING GROUP ON THE EVALUATIO
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PARTICIPANTS 5 Observer, representi
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PREAMBLE
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10 IARC MONOGRAPHS VOLUME 82 plasms
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12 IARC MONOGRAPHS VOLUME 82 collec
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14 agents present. For processes, i
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16 IARC MONOGRAPHS VOLUME 82 Finall
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18 IARC MONOGRAPHS VOLUME 82 and mi
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20 IARC MONOGRAPHS VOLUME 82 (c) St
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22 IARC MONOGRAPHS VOLUME 82 may le
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24 IARC MONOGRAPHS VOLUME 82 It is
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26 IARC MONOGRAPHS VOLUME 82 Data r
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28 when there is strong evidence th
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30 IARC MONOGRAPHS VOLUME 82 Vol. 7
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GENERAL REMARKS ON THE SUBSTANCES C
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SOME TRADITIONAL HERBAL MEDICINES
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44 which may include, for example,
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46 2. Use of Traditional Herbal Med
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48 IARC MONOGRAPHS VOLUME 82 decade
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50 IARC MONOGRAPHS VOLUME 82 Table
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52 3.2.1 Definition of herbal medic
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54 3.2.8 Individual supply Herbal m
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58 3.3.2 Germany (see Kraft, 1999;
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60 beyond placebo, and this informa
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62 3.3.5 Canada The Canadian Food a
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64 of adverse reactions to OTC drug
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66 IARC MONOGRAPHS VOLUME 82 3.3.12
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68 IARC MONOGRAPHS VOLUME 82 Jellin
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70 IARC MONOGRAPHS VOLUME 82 Simila
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72 IARC MONOGRAPHS VOLUME 82 Figure
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74 diameter of 4-6 cm or more, lobe
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76 1.2 Use 1.2.1 Aristolochia conto
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78 1.3.3 Aristolochia fangchi Compo
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80 1.6.2 Structural and molecular f
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82 chromatographic separation with
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84 may contain aristolochic acids.
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86 IARC MONOGRAPHS VOLUME 82 A bila
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88 received distilled water. The an
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90 IARC MONOGRAPHS VOLUME 82 Figure
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92 varied from undetectable (< 0.02
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94 lochic acids enhanced immune res
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96 4.4 Genetic and related effects
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Table 3 (contd) Details of study DN
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Table 4. DNA adduct formation with
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Table 4 (contd) Details of study Co
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Table 5 (contd) Species Treatment I
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Table 6. DNA adduct formation by ar
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Table 6 (contd) Test system Assay D
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Table 6 (contd) Test system Assay D
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Table 7. Polymerase action on arist
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Table 8 (contd) Test system Drosoph
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116 of the forestomach and lung of
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118 lochic acid II (three metabolit
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120 IARC MONOGRAPHS VOLUME 82 Che,
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122 IARC MONOGRAPHS VOLUME 82 Healt
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124 IARC MONOGRAPHS VOLUME 82 Nishi
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126 IARC MONOGRAPHS VOLUME 82 Schme
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128 IARC MONOGRAPHS VOLUME 82 Yang,
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130 Figure 1. Morinda officinalis H
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132 1.3.2 Morinda officinalis A num
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134 by Soxhlet extraction with ethy
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136 2.1 Case-control studies 2.1.1
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138 3. Studies of Cancer in Experim
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140 1,3-Dihydroxy-2-hydroxymethylan
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142 4.3 Reproductive and developmen
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Table 1 (contd) Test system Result
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146 5.1 Exposure data 5. Summary of
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148 IARC MONOGRAPHS VOLUME 82 Brigg
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150 IARC MONOGRAPHS VOLUME 82 Nusko
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D. SENECIO SPECIES AND RIDDELLIINE
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metry (Witte et al., 1992). Thin-la
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sex were killed after a seven-week
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4.2.2 Experimental systems SOME TRA
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Table 1. Genetic and related effect
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Riddelliine induced unscheduled DNA
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5.3 Animal carcinogenicity data In
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SOME TRADITIONAL HERBAL MEDICINES 1
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SOME MYCOTOXINS
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172 Aflatoxin G 1 IARC MONOGRAPHS V
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Table 2 (contd) Method no. Aflatoxi
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178 indicates that A. flavus and A.
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Table 4. Occurrence of aflatoxin B1
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182 IARC MONOGRAPHS VOLUME 82 aflat
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Table 6. Co-occurrence of aflatoxin
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186 IARC MONOGRAPHS VOLUME 82 Figur
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188 1.4 International exposure esti
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190 (c) Impact of establishing maxi
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192 IARC MONOGRAPHS VOLUME 82 used
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Table 10 (contd) Reference Area Uni
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198 were collapsed into a conventio
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Table 11 (contd) Reference Area Stu
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202 IARC MONOGRAPHS VOLUME 82 histo
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204 IARC MONOGRAPHS VOLUME 82 resid
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Table 12. Summary of principal case
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208 IARC MONOGRAPHS VOLUME 82 disea
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210 3. Studies of Cancer in Experim
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212 IARC MONOGRAPHS VOLUME 82 diet
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214 3.4 Administration with known c
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216 IARC MONOGRAPHS VOLUME 82 The 8
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218 observed in rat liver slices, a
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222 IARC MONOGRAPHS VOLUME 82 an α
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224 (mainly hepatocellular carcinom
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226 IARC MONOGRAPHS VOLUME 82 but i
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228 lordosis and reduction in conce
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232 IARC MONOGRAPHS VOLUME 82 sampl
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234 In eight subjects (four from Ho
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240 IARC MONOGRAPHS VOLUME 82 anima
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242 difference between the two stud
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244 IARC MONOGRAPHS VOLUME 82 HBV-t
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246 In a large cohort study in Shan
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248 experimental data in showing th
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250 IARC MONOGRAPHS VOLUME 82 Ander
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252 IARC MONOGRAPHS VOLUME 82 Buetl
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254 IARC MONOGRAPHS VOLUME 82 Denis
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256 IARC MONOGRAPHS VOLUME 82 Galla
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258 IARC MONOGRAPHS VOLUME 82 Heino
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260 IARC MONOGRAPHS VOLUME 82 Jalon
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262 IARC MONOGRAPHS VOLUME 82 Kirk,
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264 IARC MONOGRAPHS VOLUME 82 Lunn,
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266 IARC MONOGRAPHS VOLUME 82 Olubu
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268 IARC MONOGRAPHS VOLUME 82 Roll,
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270 IARC MONOGRAPHS VOLUME 82 Stett
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272 IARC MONOGRAPHS VOLUME 82 Verge
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274 IARC MONOGRAPHS VOLUME 82 Yang,
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Table 1. IARC evaluations Previous
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278 kernels and in less than 0.1% o
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280 2.5.3 Cottonseed A. flavus is a
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294 IARC MONOGRAPHS VOLUME 82 8. Re
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296 IARC MONOGRAPHS VOLUME 82 Guo,
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298 IARC MONOGRAPHS VOLUME 82 Marti
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300 IARC MONOGRAPHS VOLUME 82 Sharm
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302 (d ) Solubility: Soluble in wat
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304 1.4 Occurrence Fumonisins have
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306 Table 1 (contd) IARC MONOGRAPHS
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308 (c) Formation in commodities ot
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312 IARC MONOGRAPHS VOLUME 82 3.1 O
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314 3.2.2 Rat IARC MONOGRAPHS VOLUM
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316 with NDEA and fumonisin B 1, wh
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318 IARC MONOGRAPHS VOLUME 82 In pi
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Figure 2. Allometric relationship b
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322 IARC MONOGRAPHS VOLUME 82 obser
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324 IARC MONOGRAPHS VOLUME 82 Hepat
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326 4.2.3 Related studies IARC MONO
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328 4.3.2 Experimental systems IARC
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330 and litters on postnatal day 21
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Table 4. Genetic and related effect
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334 IARC MONOGRAPHS VOLUME 82 The f
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336 IARC MONOGRAPHS VOLUME 82 (d )
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338 IARC MONOGRAPHS VOLUME 82 treat
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340 4.5.2 Interference with fatty a
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344 5.2 Human carcinogenicity data
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346 IARC MONOGRAPHS VOLUME 82 Alber
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348 IARC MONOGRAPHS VOLUME 82 Chamb
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350 IARC MONOGRAPHS VOLUME 82 Floss
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352 IARC MONOGRAPHS VOLUME 82 Hiroo
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354 IARC MONOGRAPHS VOLUME 82 Lee,
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356 IARC MONOGRAPHS VOLUME 82 Mobio
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358 IARC MONOGRAPHS VOLUME 82 Prelu
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360 IARC MONOGRAPHS VOLUME 82 Savar
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362 IARC MONOGRAPHS VOLUME 82 Steve
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364 IARC MONOGRAPHS VOLUME 82 Flett
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366 IARC MONOGRAPHS VOLUME 82 Yu, C
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368 disulfide, carbon tetrachloride
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Table 1 (contd) Sample matrix Sampl
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Table 3. Naphthalene production (th
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374 1.4 Occurrence 1.4.1 Natural oc
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Table 5. Occupational exposure to n
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378 water assuming a water concentr
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380 (Scheepers & Bos, 1992). The av
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382 (d ) Biodegradation Studies on
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386 3.2 Inhalation exposure 3.2.1 M
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388 3.3.2 Rat Ten BD I and BD III r
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Figure 1. Main metabolic pathways o
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392 IARC MONOGRAPHS VOLUME 82 and t
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394 IARC MONOGRAPHS VOLUME 82 and 1
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396 IARC MONOGRAPHS VOLUME 82 1-240
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398 IARC MONOGRAPHS VOLUME 82 Perfu
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Page 423 and 424: 416 assay with or without metabolic
Page 425 and 426: 418 There is some evidence of devel
Page 427 and 428: 420 IARC MONOGRAPHS VOLUME 82 Bjør
Page 429 and 430: 422 IARC MONOGRAPHS VOLUME 82 Conkl
Page 431 and 432: 424 IARC MONOGRAPHS VOLUME 82 Envir
Page 433 and 434: 426 IARC MONOGRAPHS VOLUME 82 Ho, C
Page 435 and 436: 428 IARC MONOGRAPHS VOLUME 82 Lynch
Page 437 and 438: 430 IARC MONOGRAPHS VOLUME 82 O’B
Page 439 and 440: 432 IARC MONOGRAPHS VOLUME 82 Schee
Page 441 and 442: 434 IARC MONOGRAPHS VOLUME 82 Versc
Page 444 and 445: STYRENE This substance was consider
Page 446 and 447: EPA Method 8260B can be used to det
Page 448 and 449: Styrene is produced mainly by catal
Page 450 and 451: STYRENE 443 Table 3. Use patterns f
Page 452 and 453: STYRENE 445 most samples taken from
Page 454 and 455: STYRENE 447 successive layers of ch
Page 456 and 457: Table 4 (contd) Country and year of
Page 460 and 461: STYRENE 453 Since 1990, the long-te
Page 462 and 463: same products resulted in exposures
Page 464 and 465: STYRENE 457 Ambient air monitoring
Page 466 and 467: 200 μg/kg, although 77% of the foo
Page 468 and 469: Table 8 (contd) Country or region Y
Page 470 and 471: 2.1 Case reports 2. Studies of Canc
Page 472 and 473: Table 10 (contd) Reference (country
Page 474 and 475: Table 10 (contd) Reference (country
Page 476 and 477: STYRENE 469 (95% CI, 1.4-5.2; 10 de
Page 478 and 479: who had been employed in 1964-70 (t
Page 480 and 481: elationship for styrene became nega
Page 482 and 483: atio, 4.4; 95% CI, 1.1-17 in multip
Page 484 and 485: controls versus 32/32 treated). No
Page 486 and 487: 3.4 Intraperitoneal administration
Page 488 and 489: Figure 1. Main metabolic pathways f
Page 490 and 491: STYRENE 483 a maximum and averaged
Page 492 and 493: (b) Distribution STYRENE 485 An ear
Page 494 and 495: STYRENE 487 rats with phenobarbital
Page 496 and 497: STYRENE 489 gavage (100-350 mg/kg b
Page 498 and 499: CYP2E1 and CYP2F2) inhibited nasal
Page 500 and 501: model indicated that absorbed styre
Page 502 and 503: female workers in the glass fibre-r
Page 504 and 505: STYRENE 497 continuously for seven
Page 506 and 507: STYRENE 499 exposure concentrations
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STYRENE 501 The frequency of sponta
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STYRENE 503 groups. Only minor gene
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concentrations of styrene in air we
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Table 12. Cytogenetic studies in ly
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Table 13. Genetic and related effec
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(b) Experimental systems (see Table
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STYRENE 515 styrene 7,8-oxide. Joha
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Styrene 7,8-oxide can bind to DNA w
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STYRENE 519 a small and non-signifi
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STYRENE 521 and immune systems, liv
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STYRENE 523 Artuso, M., Angotzi, G.
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STYRENE 525 Brugnone, F., Perbellin
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STYRENE 527 Coccini, T., Maestri, L
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STYRENE 529 Edling, C., Anundi, H.,
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STYRENE 531 Gobba, F., Galassi, C.,
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STYRENE 533 Horvath, E., Pongracz,
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STYRENE 535 logical Study and the I
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STYRENE 537 Linhart, I., Gut, I.,
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STYRENE 539 Miller, S.L., Branoff,
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STYRENE 541 Newhook, R. & Caldwell,
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STYRENE 543 Pryor, G.T., Rebert, C.
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STYRENE 545 Sielken, R.L. & Valdez-
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STYRENE 547 Tsuda, S., Matsusaka, N
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STYRENE 549 Boffetta, P. (1996b) Ex
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Agent SUMMARY OF FINAL EVALUATIONS
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554 IARC MONOGRAPHS VOLUME 82 DGAL:
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556 IARC MONOGRAPHS VOLUME 82 PMTDI
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558 IARC MONOGRAPHS VOLUME 82 Aldri
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560 IARC MONOGRAPHS VOLUME 82 Benz[
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562 β-Butyrolactone 11, 225 (1976)
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564 IARC MONOGRAPHS VOLUME 82 Chlor
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566 Cyproterone acetate 72, 49 (199
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568 IARC MONOGRAPHS VOLUME 82 Diepo
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570 Ethionamide 13, 83 (1977); Supp
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572 IARC MONOGRAPHS VOLUME 82 Haema
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574 L Lasiocarpine 10, 281 (1976);
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576 IARC MONOGRAPHS VOLUME 82 Methy
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578 IARC MONOGRAPHS VOLUME 82 Nicke
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580 O Ochratoxin A 10, 191 (1976);
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582 IARC MONOGRAPHS VOLUME 82 Polyb
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584 Rhodamine 6G 16, 233 (1978); Su
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586 Sulfafurazole 24, 275 (1980); S
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588 1,1,1-Trichloroethane 20, 515 (
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590 Y Yellow AB 8, 279 (1975); Supp
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Volume 31 Some Food Additives, Feed
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