IARC MONOGRAPHS ON THE EVALUATION OF CARCINOGENIC ...

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Table 1. Genetic and related effects of riddelliine and its metabolite dehydroxyretronecine Test system Result a Without exogenous metabolic system With exogenous metabolic system Dose b (LED or HID) Reference Riddelliine Salmonella typhimurium TA1535, TA97, TA98, reverse mutation – – 5000 μg/plate Zeiger et al. (1988) Salmonella typhimurium TA100, reverse mutation – + 1000 μg/plate Zeiger et al. (1988) DNA-protein cross-links, bovine kidney (MDBK) CCL 22 cells + + 17.5 Hincks et al. (1991) in vitro Sister chromatid exchange, Chinese hamster ovary cells in vitro + + 3 Galloway et al. (1987) Chromosomal aberrations, Chinese hamster ovary cells in vitro – + 300 Galloway et al. (1987) Cell transformation, BALB/c3T3 mouse cells, in vitro + NT 225 Matthews et al. (1993) Unscheduled DNA synthesis, male and female Fischer 344 rat + 50 po × 1 Mirsalis (1987) hepatocytes in vivo Unscheduled DNA synthesis, male and female Fischer 344 rat hepatocytes in vivo – 25 po 30 d c Mirsalis et al. (1993) Unscheduled DNA synthesis, male and female B6C3F1 mouse hepatocytes in vivo ? d 25 po 30 d c Mirsalis et al. (1993) Unscheduled DNA synthesis, male and female B6C3F1 mouse hepatocytes in vivo + 25 po × 5 Chan et al. (1994) Unscheduled DNA synthesis, male and female Fischer 344 rat hepatocytes in vivo + 1 po × 5 Chan et al. (1994) Micronucleus induction, male and female B6C3F1 mouse bone marrow, in vivo – 25 po 5 or 30 d c Mirsalis et al. (1993) Micronucleus induction, male B6C3F1 mouse peripheral blood, + 150 po × 1 Chan et al. (1994) in vivo Micronucleus induction, male B6C3F1 mouse bone marrow, in vivo + 270 po × 1 Chan et al. (1994) SOME TRADITIONAL HERBAL MEDICINES 161
Table 1 (contd) Test system Result a Micronucleus induction, male Swiss mouse peripheral blood erythrocytes, in vivo Micronucleus induction, male Swiss mouse bone-marrow erythrocytes, in vivo Micronucleus induction, male and female B6C3F1 mouse peripheral blood, in vivo Micronucleus induction, male and female Fischer 344 rat bone marrow, in vivo DNA adducts, female Fischer 344 rat liver, in vivo, 32 P-postlabelling Without exogenous metabolic system With exogenous metabolic system Dose b (LED or HID) Reference + 150 ip × 1 National Toxicology Program (2002) + 270 ip × 1 National Toxicology Program (2002) – 25 po 13 wk Witt et al. (2000) – 3.3 po 30 d c Mirsalis et al. (1993) + 0.01 po 3 mo c Yang et al. (2001a) Dehydroretronecine Salmonella typhimurium TA92, reverse mutation + NT 500 μg/plate Ord et al. (1985) DNA cross-links, pBR322 plasmid and M13 viral DNA + NT 29 Reed et al. (1988) DNA–protein cross-links, bovine kidney (MDBK) CCL22 cells + NT 46 Kim et al. (1995) in vitro Sister chromatid exchange, human lymphocytes in vitro + NT 0.12 Ord et al. (1985) DNA adducts, calf thymus DNA in vitro + NT 3.9 Yang et al. (2001b) Alkylation of N 2 of deoxyguanosine in vitro + NT 1530 Robertson (1982) a +, positive; (+), weak positive; –, negative; NT, not tested; ?, inconclusive b LED, lowest effective dose; HID, highest ineffective dose; in-vitro tests, μg/mL; in-vivo tests, mg/kg bw/day; d, day; po, oral; ip, intraperitoneal; mo, month; wk, week c Treated 5 days/week d Equivocal response in males; modest response in females at highest dose only 162 IARC MONOGRAPHS VOLUME 82
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WORLD HEALTH ORGANIZATION INTERNATI
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IARC MONOGRAPHS In 1969, the Intern
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iv IARC MONOGRAPHS VOLUME 82 3.2 Th
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vi IARC MONOGRAPHS VOLUME 82 SOME M
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IARC WORKING GROUP ON THE EVALUATIO
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PARTICIPANTS 5 Observer, representi
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PREAMBLE
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10 IARC MONOGRAPHS VOLUME 82 plasms
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12 IARC MONOGRAPHS VOLUME 82 collec
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14 agents present. For processes, i
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16 IARC MONOGRAPHS VOLUME 82 Finall
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18 IARC MONOGRAPHS VOLUME 82 and mi
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20 IARC MONOGRAPHS VOLUME 82 (c) St
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22 IARC MONOGRAPHS VOLUME 82 may le
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24 IARC MONOGRAPHS VOLUME 82 It is
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26 IARC MONOGRAPHS VOLUME 82 Data r
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28 when there is strong evidence th
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30 IARC MONOGRAPHS VOLUME 82 Vol. 7
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GENERAL REMARKS ON THE SUBSTANCES C
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SOME TRADITIONAL HERBAL MEDICINES
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44 which may include, for example,
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46 2. Use of Traditional Herbal Med
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48 IARC MONOGRAPHS VOLUME 82 decade
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50 IARC MONOGRAPHS VOLUME 82 Table
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52 3.2.1 Definition of herbal medic
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54 3.2.8 Individual supply Herbal m
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58 3.3.2 Germany (see Kraft, 1999;
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60 beyond placebo, and this informa
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62 3.3.5 Canada The Canadian Food a
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64 of adverse reactions to OTC drug
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66 IARC MONOGRAPHS VOLUME 82 3.3.12
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68 IARC MONOGRAPHS VOLUME 82 Jellin
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70 IARC MONOGRAPHS VOLUME 82 Simila
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72 IARC MONOGRAPHS VOLUME 82 Figure
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74 diameter of 4-6 cm or more, lobe
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76 1.2 Use 1.2.1 Aristolochia conto
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78 1.3.3 Aristolochia fangchi Compo
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80 1.6.2 Structural and molecular f
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82 chromatographic separation with
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84 may contain aristolochic acids.
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86 IARC MONOGRAPHS VOLUME 82 A bila
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88 received distilled water. The an
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90 IARC MONOGRAPHS VOLUME 82 Figure
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92 varied from undetectable (< 0.02
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94 lochic acids enhanced immune res
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96 4.4 Genetic and related effects
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Table 3 (contd) Details of study DN
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Table 4. DNA adduct formation with
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Table 4 (contd) Details of study Co
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Table 5 (contd) Species Treatment I
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Table 6. DNA adduct formation by ar
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Table 6 (contd) Test system Assay D
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Page 119 and 120: Table 7. Polymerase action on arist
Page 121 and 122: Table 8 (contd) Test system Drosoph
Page 123 and 124: 116 of the forestomach and lung of
Page 125 and 126: 118 lochic acid II (three metabolit
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Page 133 and 134: 126 IARC MONOGRAPHS VOLUME 82 Schme
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Page 137 and 138: 130 Figure 1. Morinda officinalis H
Page 139 and 140: 132 1.3.2 Morinda officinalis A num
Page 141 and 142: 134 by Soxhlet extraction with ethy
Page 143 and 144: 136 2.1 Case-control studies 2.1.1
Page 145 and 146: 138 3. Studies of Cancer in Experim
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Page 149 and 150: 142 4.3 Reproductive and developmen
Page 151 and 152: Table 1 (contd) Test system Result
Page 153 and 154: 146 5.1 Exposure data 5. Summary of
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Page 157 and 158: 150 IARC MONOGRAPHS VOLUME 82 Nusko
Page 160 and 161: D. SENECIO SPECIES AND RIDDELLIINE
Page 162 and 163: metry (Witte et al., 1992). Thin-la
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Page 166 and 167: 4.2.2 Experimental systems SOME TRA
Page 170 and 171: Riddelliine induced unscheduled DNA
Page 172 and 173: 5.3 Animal carcinogenicity data In
Page 174 and 175: SOME TRADITIONAL HERBAL MEDICINES 1
Page 176: SOME MYCOTOXINS
Page 179 and 180: 172 Aflatoxin G 1 IARC MONOGRAPHS V
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Page 183 and 184: Table 2 (contd) Method no. Aflatoxi
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Page 187 and 188: Table 4. Occurrence of aflatoxin B1
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Page 191 and 192: Table 6. Co-occurrence of aflatoxin
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Page 195 and 196: 188 1.4 International exposure esti
Page 197 and 198: 190 (c) Impact of establishing maxi
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Page 203 and 204: Table 10 (contd) Reference Area Uni
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Page 207 and 208: Table 11 (contd) Reference Area Stu
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Page 211 and 212: 204 IARC MONOGRAPHS VOLUME 82 resid
Page 213 and 214: Table 12. Summary of principal case
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Page 217 and 218: 210 3. Studies of Cancer in Experim
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212 IARC MONOGRAPHS VOLUME 82 diet
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214 3.4 Administration with known c
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216 IARC MONOGRAPHS VOLUME 82 The 8
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218 observed in rat liver slices, a
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220 IARC MONOGRAPHS VOLUME 82 Figur
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222 IARC MONOGRAPHS VOLUME 82 an α
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224 (mainly hepatocellular carcinom
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226 IARC MONOGRAPHS VOLUME 82 but i
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228 lordosis and reduction in conce
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232 IARC MONOGRAPHS VOLUME 82 sampl
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234 In eight subjects (four from Ho
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Table 16 (contd) Test system Result
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238 IARC MONOGRAPHS VOLUME 82 aflat
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240 IARC MONOGRAPHS VOLUME 82 anima
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242 difference between the two stud
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244 IARC MONOGRAPHS VOLUME 82 HBV-t
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246 In a large cohort study in Shan
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248 experimental data in showing th
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250 IARC MONOGRAPHS VOLUME 82 Ander
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252 IARC MONOGRAPHS VOLUME 82 Buetl
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254 IARC MONOGRAPHS VOLUME 82 Denis
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256 IARC MONOGRAPHS VOLUME 82 Galla
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258 IARC MONOGRAPHS VOLUME 82 Heino
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260 IARC MONOGRAPHS VOLUME 82 Jalon
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262 IARC MONOGRAPHS VOLUME 82 Kirk,
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264 IARC MONOGRAPHS VOLUME 82 Lunn,
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266 IARC MONOGRAPHS VOLUME 82 Olubu
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268 IARC MONOGRAPHS VOLUME 82 Roll,
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270 IARC MONOGRAPHS VOLUME 82 Stett
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272 IARC MONOGRAPHS VOLUME 82 Verge
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274 IARC MONOGRAPHS VOLUME 82 Yang,
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Table 1. IARC evaluations Previous
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278 kernels and in less than 0.1% o
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280 2.5.3 Cottonseed A. flavus is a
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294 IARC MONOGRAPHS VOLUME 82 8. Re
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296 IARC MONOGRAPHS VOLUME 82 Guo,
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298 IARC MONOGRAPHS VOLUME 82 Marti
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300 IARC MONOGRAPHS VOLUME 82 Sharm
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302 (d ) Solubility: Soluble in wat
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304 1.4 Occurrence Fumonisins have
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306 Table 1 (contd) IARC MONOGRAPHS
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308 (c) Formation in commodities ot
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312 IARC MONOGRAPHS VOLUME 82 3.1 O
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314 3.2.2 Rat IARC MONOGRAPHS VOLUM
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316 with NDEA and fumonisin B 1, wh
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318 IARC MONOGRAPHS VOLUME 82 In pi
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Figure 2. Allometric relationship b
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322 IARC MONOGRAPHS VOLUME 82 obser
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324 IARC MONOGRAPHS VOLUME 82 Hepat
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326 4.2.3 Related studies IARC MONO
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328 4.3.2 Experimental systems IARC
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330 and litters on postnatal day 21
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Table 4. Genetic and related effect
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334 IARC MONOGRAPHS VOLUME 82 The f
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336 IARC MONOGRAPHS VOLUME 82 (d )
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338 IARC MONOGRAPHS VOLUME 82 treat
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340 4.5.2 Interference with fatty a
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344 5.2 Human carcinogenicity data
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346 IARC MONOGRAPHS VOLUME 82 Alber
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348 IARC MONOGRAPHS VOLUME 82 Chamb
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350 IARC MONOGRAPHS VOLUME 82 Floss
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352 IARC MONOGRAPHS VOLUME 82 Hiroo
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354 IARC MONOGRAPHS VOLUME 82 Lee,
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356 IARC MONOGRAPHS VOLUME 82 Mobio
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358 IARC MONOGRAPHS VOLUME 82 Prelu
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360 IARC MONOGRAPHS VOLUME 82 Savar
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362 IARC MONOGRAPHS VOLUME 82 Steve
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364 IARC MONOGRAPHS VOLUME 82 Flett
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366 IARC MONOGRAPHS VOLUME 82 Yu, C
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368 disulfide, carbon tetrachloride
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Table 1 (contd) Sample matrix Sampl
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Table 3. Naphthalene production (th
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374 1.4 Occurrence 1.4.1 Natural oc
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Table 5. Occupational exposure to n
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378 water assuming a water concentr
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380 (Scheepers & Bos, 1992). The av
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382 (d ) Biodegradation Studies on
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386 3.2 Inhalation exposure 3.2.1 M
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388 3.3.2 Rat Ten BD I and BD III r
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Figure 1. Main metabolic pathways o
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392 IARC MONOGRAPHS VOLUME 82 and t
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394 IARC MONOGRAPHS VOLUME 82 and 1
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396 IARC MONOGRAPHS VOLUME 82 1-240
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398 IARC MONOGRAPHS VOLUME 82 Perfu
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400 Siegel and Wason (1986) reviewe
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402 IARC MONOGRAPHS VOLUME 82 liver
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404 IARC MONOGRAPHS VOLUME 82 to id
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406 IARC MONOGRAPHS VOLUME 82 Alkal
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408 hyperplasia, atrophy, chronic i
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410 had deficient glucose-6-phospha
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Table 10. Genetic and related effec
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Table 10 (contd) Test system Micron
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416 assay with or without metabolic
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418 There is some evidence of devel
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420 IARC MONOGRAPHS VOLUME 82 Bjør
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422 IARC MONOGRAPHS VOLUME 82 Conkl
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424 IARC MONOGRAPHS VOLUME 82 Envir
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426 IARC MONOGRAPHS VOLUME 82 Ho, C
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428 IARC MONOGRAPHS VOLUME 82 Lynch
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430 IARC MONOGRAPHS VOLUME 82 O’B
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432 IARC MONOGRAPHS VOLUME 82 Schee
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434 IARC MONOGRAPHS VOLUME 82 Versc
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STYRENE This substance was consider
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EPA Method 8260B can be used to det
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Styrene is produced mainly by catal
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STYRENE 443 Table 3. Use patterns f
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STYRENE 445 most samples taken from
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STYRENE 447 successive layers of ch
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Table 4 (contd) Country and year of
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Table 5. Biological monitoring of o
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STYRENE 453 Since 1990, the long-te
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same products resulted in exposures
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STYRENE 457 Ambient air monitoring
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200 μg/kg, although 77% of the foo
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Table 8 (contd) Country or region Y
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2.1 Case reports 2. Studies of Canc
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Table 10 (contd) Reference (country
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Table 10 (contd) Reference (country
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STYRENE 469 (95% CI, 1.4-5.2; 10 de
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who had been employed in 1964-70 (t
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elationship for styrene became nega
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atio, 4.4; 95% CI, 1.1-17 in multip
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controls versus 32/32 treated). No
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3.4 Intraperitoneal administration
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Figure 1. Main metabolic pathways f
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STYRENE 483 a maximum and averaged
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(b) Distribution STYRENE 485 An ear
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STYRENE 487 rats with phenobarbital
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STYRENE 489 gavage (100-350 mg/kg b
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CYP2E1 and CYP2F2) inhibited nasal
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model indicated that absorbed styre
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female workers in the glass fibre-r
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STYRENE 497 continuously for seven
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STYRENE 499 exposure concentrations
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STYRENE 501 The frequency of sponta
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STYRENE 503 groups. Only minor gene
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concentrations of styrene in air we
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Table 12. Cytogenetic studies in ly
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Table 13. Genetic and related effec
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(b) Experimental systems (see Table
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Table 14 (contd) Test system Result
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STYRENE 515 styrene 7,8-oxide. Joha
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Styrene 7,8-oxide can bind to DNA w
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STYRENE 519 a small and non-signifi
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STYRENE 521 and immune systems, liv
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STYRENE 523 Artuso, M., Angotzi, G.
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STYRENE 525 Brugnone, F., Perbellin
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STYRENE 527 Coccini, T., Maestri, L
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STYRENE 529 Edling, C., Anundi, H.,
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STYRENE 531 Gobba, F., Galassi, C.,
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STYRENE 533 Horvath, E., Pongracz,
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STYRENE 535 logical Study and the I
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STYRENE 537 Linhart, I., Gut, I.,
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STYRENE 539 Miller, S.L., Branoff,
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STYRENE 541 Newhook, R. & Caldwell,
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STYRENE 543 Pryor, G.T., Rebert, C.
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STYRENE 545 Sielken, R.L. & Valdez-
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STYRENE 547 Tsuda, S., Matsusaka, N
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STYRENE 549 Boffetta, P. (1996b) Ex
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Agent SUMMARY OF FINAL EVALUATIONS
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554 IARC MONOGRAPHS VOLUME 82 DGAL:
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556 IARC MONOGRAPHS VOLUME 82 PMTDI
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558 IARC MONOGRAPHS VOLUME 82 Aldri
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560 IARC MONOGRAPHS VOLUME 82 Benz[
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562 β-Butyrolactone 11, 225 (1976)
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564 IARC MONOGRAPHS VOLUME 82 Chlor
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566 Cyproterone acetate 72, 49 (199
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568 IARC MONOGRAPHS VOLUME 82 Diepo
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570 Ethionamide 13, 83 (1977); Supp
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572 IARC MONOGRAPHS VOLUME 82 Haema
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574 L Lasiocarpine 10, 281 (1976);
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576 IARC MONOGRAPHS VOLUME 82 Methy
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578 IARC MONOGRAPHS VOLUME 82 Nicke
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580 O Ochratoxin A 10, 191 (1976);
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582 IARC MONOGRAPHS VOLUME 82 Polyb
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584 Rhodamine 6G 16, 233 (1978); Su
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586 Sulfafurazole 24, 275 (1980); S
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588 1,1,1-Trichloroethane 20, 515 (
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590 Y Yellow AB 8, 279 (1975); Supp
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Volume 31 Some Food Additives, Feed
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