IARC MONOGRAPHS ON THE EVALUATION OF CARCINOGENIC ...

Table 12. Cytogenetic studies in lymphocytes from individuals occupationally exposed to styrene
No. of
exposed
No. of
controls
Years of exposure Styrene in air (mg/m 3 ) Urinary mandelic acid
(mg/g creatinine)
Cytogenetic observation
Range Mean Range Mean Range Mean CA MN SCE
Reference
28 20 1–26 8 125–180 157 a
652 mg/L + Hallier et al. (1994)
52 24 2.9 2.2–111 31 11–649 102 – – Van Hummelen et al.
(1994)
18 18 10–22 14.3 NR 328 + – Anwar & Shamy
(1995)
23 51 86–1390 + + Artuso et al. (1995)
2–120 (+) (+)
53 41 9.9 85–1280 129 14–
1482 b
207 b
– + Karakaya et al.
(1997)
44 19 14 27–199 c
101 + Somorovská et al.
(1999)
CA, chromosomal aberrations; MN, micronuclei; SCE, sister chromatid exchange; NR, not reported
a After modifications were made to the plant to lower styrene concentrations below 85 mg/m 3 , results from SCE test were negative.
b Mandelic acid + phenylglyoxylic acid
c Range of means
STYRENE 507