IARC MONOGRAPHS ON THE EVALUATION OF CARCINOGENIC ...

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Table 11. Summary of the principal cohort and nested case–control studies on liver cancer and aflatoxins Reference Area Study base Type of analysis Exposure measures Outcome measures Hayes et al. (1984) Yeh et al. (1985) Olsen et al. (1988) Yeh et al. (1989) Netherlands 71 male oil-press workers exposed to dust containing aflatoxin China Selected villages in Fusui county, Guangxi Denmark Male employees of 241 livestock feed companies, employed after 1964 China Five communities of southern Guangxi Province, men enrolled in 1982–83; n > 7917 Cohort – SMR comparisons with Dutch males Cohort (ecological exposure) Worked > 2 years in exposed area during 1961–70 Village mean for intake of aflatoxin based on food samples. ∼10-fold difference between low and high contamination areas Cohort SPIR Longest-held job (> 1964) in one of 241 companies Cohort – PHC mortality rates in different categories of estimated mean AFB1 consumption Mean AFB1 level of community of residence, as estimated from food samples collected from all over the region; 1978–84 Cancer mortality Liver cancer mortality Liver cancer incidence traced in Danish Cancer Registry; 1970–84 Mortality from PHC based on follow-up 1984–86 Covariate Results Comments – Cases SMR 95% CI HBsAg measured among cases HBsAg in cases and subcohort Lung cancer 7 2.5 1.0–5.0 Liver cancer 0 0 NA Aflatoxin HBsAg HCC deaths______ contami- status No. Rate per nation 1000 p–yr __________________________________ Heavy Positive 13 649 Negative 2 99 Light Positive 1 66 Negative 0 0 Longest employment Cases SPIR 95% CI _________________________________ Ever 6 1.4 0.57–2.9 ≥ 10 yrs before diagnosis 7 2.5 1.1–4.9 Strong correlation between PHC mortality and estimated levels of AFB1 in 4 communities; aflatoxin levels not available in one community (Pearson correlation coefficient, 1.00; p = 0.004) Incomplete study description [unit presumed to be: per 1000 p–yr] Confounding by HBV and alcohol unlikely Strong association observed between HBsAg and PHC mortality in cohort and nested case–control analysis (RR = 32); not seen in the ecological analysis (r = 0.28; p = 0.65) AFLATOXINS 199
Table 11 (contd) Reference Area Study base Type of analysis Exposure measures Outcome measures Qian et al. (1994); Ross et al. (1992) Chen et al. (1996) Wang et al. (1996a) Shanghai, China Taiwan, China Taiwan, China Men, mainly 45–64 years old; n = 18 244. Resident in one of four areas. Recruited during 1986–89 Penghu Islets. Over 6000 subjects enrolled. Possibly a subset of the cohort of Wang et al. (1996) 7 townships. Over 25 000 subjects enrolled in cohort Both cohort analysis and a nested case– control analysis with 50 cases and 267 matched controls Nested case–control analysis based on 20 cases and 86 controls Nested case–control analysis based on 56 cases and 220 controls Detailed dietary history linked to measured levels in sample foods Measured urinary aflatoxin and aflatoxin–guanine adducts Measured AFB1– albumin adducts Biomarker measurement of urinary aflatoxins and aflatoxin–albumin adducts Liver cancer mortality and incidence follow-up to 1992. Intensive tracing HCC, ascertained by an active diagnostic procedure HCC, ascertained by a variety of tracing sources, 1991–95 Covariate Results Comments Measured HBsAg, cigarette smoking Sociodemographiccharacteristics, HBsAg, anti- HCV, family history of HCC and liver cirrhosis Sociodemographic characteristics and HBsAg Aflatoxin Cases RR 95% CI Medium 25 1.6 0.8–3.1 Heavy 16 0.9 0.4–1.9 Cases OR 95% CI Aflatoxin– 18 9.1 2.9–29 guanine adducts Any bio- 36 5.0 2.1–12 marker of aflatoxin Joint exposure 23 59 17–212 to any biomarker of aflatoxin and HBsAg Cases OR 95% CI AFB1– 13 5.5 1.2–25 albumin adducts Cases OR 95% CI Aflatoxin– 31 1.6* 0.4–5.5 albumin adducts Urinary 26 3.8* 1.1–13 aflatoxin Urinary 22 112 14–905 aflatoxin + HBsAg Cohort analysis Nested case–control analysis *Adjusted for HBsAg 200 IARC MONOGRAPHS VOLUME 82
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WORLD HEALTH ORGANIZATION INTERNATI
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IARC MONOGRAPHS In 1969, the Intern
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iv IARC MONOGRAPHS VOLUME 82 3.2 Th
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vi IARC MONOGRAPHS VOLUME 82 SOME M
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IARC WORKING GROUP ON THE EVALUATIO
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PARTICIPANTS 5 Observer, representi
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PREAMBLE
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10 IARC MONOGRAPHS VOLUME 82 plasms
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12 IARC MONOGRAPHS VOLUME 82 collec
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14 agents present. For processes, i
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16 IARC MONOGRAPHS VOLUME 82 Finall
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18 IARC MONOGRAPHS VOLUME 82 and mi
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20 IARC MONOGRAPHS VOLUME 82 (c) St
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22 IARC MONOGRAPHS VOLUME 82 may le
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24 IARC MONOGRAPHS VOLUME 82 It is
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26 IARC MONOGRAPHS VOLUME 82 Data r
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28 when there is strong evidence th
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30 IARC MONOGRAPHS VOLUME 82 Vol. 7
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GENERAL REMARKS ON THE SUBSTANCES C
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SOME TRADITIONAL HERBAL MEDICINES
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44 which may include, for example,
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46 2. Use of Traditional Herbal Med
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48 IARC MONOGRAPHS VOLUME 82 decade
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50 IARC MONOGRAPHS VOLUME 82 Table
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52 3.2.1 Definition of herbal medic
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54 3.2.8 Individual supply Herbal m
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58 3.3.2 Germany (see Kraft, 1999;
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60 beyond placebo, and this informa
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62 3.3.5 Canada The Canadian Food a
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64 of adverse reactions to OTC drug
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66 IARC MONOGRAPHS VOLUME 82 3.3.12
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68 IARC MONOGRAPHS VOLUME 82 Jellin
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70 IARC MONOGRAPHS VOLUME 82 Simila
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72 IARC MONOGRAPHS VOLUME 82 Figure
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74 diameter of 4-6 cm or more, lobe
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76 1.2 Use 1.2.1 Aristolochia conto
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78 1.3.3 Aristolochia fangchi Compo
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80 1.6.2 Structural and molecular f
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82 chromatographic separation with
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84 may contain aristolochic acids.
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86 IARC MONOGRAPHS VOLUME 82 A bila
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88 received distilled water. The an
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90 IARC MONOGRAPHS VOLUME 82 Figure
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92 varied from undetectable (< 0.02
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94 lochic acids enhanced immune res
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96 4.4 Genetic and related effects
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Table 3 (contd) Details of study DN
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Table 4. DNA adduct formation with
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Table 4 (contd) Details of study Co
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Table 5 (contd) Species Treatment I
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Table 6. DNA adduct formation by ar
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Table 6 (contd) Test system Assay D
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Table 6 (contd) Test system Assay D
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Table 7. Polymerase action on arist
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Table 8 (contd) Test system Drosoph
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116 of the forestomach and lung of
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118 lochic acid II (three metabolit
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120 IARC MONOGRAPHS VOLUME 82 Che,
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122 IARC MONOGRAPHS VOLUME 82 Healt
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124 IARC MONOGRAPHS VOLUME 82 Nishi
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126 IARC MONOGRAPHS VOLUME 82 Schme
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128 IARC MONOGRAPHS VOLUME 82 Yang,
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130 Figure 1. Morinda officinalis H
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132 1.3.2 Morinda officinalis A num
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134 by Soxhlet extraction with ethy
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136 2.1 Case-control studies 2.1.1
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138 3. Studies of Cancer in Experim
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140 1,3-Dihydroxy-2-hydroxymethylan
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142 4.3 Reproductive and developmen
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Table 1 (contd) Test system Result
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146 5.1 Exposure data 5. Summary of
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Page 160 and 161: D. SENECIO SPECIES AND RIDDELLIINE
Page 162 and 163: metry (Witte et al., 1992). Thin-la
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Page 168 and 169: Table 1. Genetic and related effect
Page 170 and 171: Riddelliine induced unscheduled DNA
Page 172 and 173: 5.3 Animal carcinogenicity data In
Page 174 and 175: SOME TRADITIONAL HERBAL MEDICINES 1
Page 176: SOME MYCOTOXINS
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Page 183 and 184: Table 2 (contd) Method no. Aflatoxi
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Page 187 and 188: Table 4. Occurrence of aflatoxin B1
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Page 191 and 192: Table 6. Co-occurrence of aflatoxin
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Page 195 and 196: 188 1.4 International exposure esti
Page 197 and 198: 190 (c) Impact of establishing maxi
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Page 203 and 204: Table 10 (contd) Reference Area Uni
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Page 213 and 214: Table 12. Summary of principal case
Page 215 and 216: 208 IARC MONOGRAPHS VOLUME 82 disea
Page 217 and 218: 210 3. Studies of Cancer in Experim
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Page 221 and 222: 214 3.4 Administration with known c
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Page 225 and 226: 218 observed in rat liver slices, a
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Page 231 and 232: 224 (mainly hepatocellular carcinom
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Page 235 and 236: 228 lordosis and reduction in conce
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Page 239 and 240: 232 IARC MONOGRAPHS VOLUME 82 sampl
Page 241 and 242: 234 In eight subjects (four from Ho
Page 243 and 244: Table 16 (contd) Test system Result
Page 247 and 248: 240 IARC MONOGRAPHS VOLUME 82 anima
Page 249 and 250: 242 difference between the two stud
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Page 253 and 254: 246 In a large cohort study in Shan
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250 IARC MONOGRAPHS VOLUME 82 Ander
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252 IARC MONOGRAPHS VOLUME 82 Buetl
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254 IARC MONOGRAPHS VOLUME 82 Denis
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256 IARC MONOGRAPHS VOLUME 82 Galla
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258 IARC MONOGRAPHS VOLUME 82 Heino
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260 IARC MONOGRAPHS VOLUME 82 Jalon
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262 IARC MONOGRAPHS VOLUME 82 Kirk,
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264 IARC MONOGRAPHS VOLUME 82 Lunn,
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266 IARC MONOGRAPHS VOLUME 82 Olubu
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268 IARC MONOGRAPHS VOLUME 82 Roll,
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270 IARC MONOGRAPHS VOLUME 82 Stett
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272 IARC MONOGRAPHS VOLUME 82 Verge
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274 IARC MONOGRAPHS VOLUME 82 Yang,
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Table 1. IARC evaluations Previous
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278 kernels and in less than 0.1% o
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280 2.5.3 Cottonseed A. flavus is a
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282 IARC MONOGRAPHS VOLUME 82 aflat
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288 IARC MONOGRAPHS VOLUME 82 Figur
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294 IARC MONOGRAPHS VOLUME 82 8. Re
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296 IARC MONOGRAPHS VOLUME 82 Guo,
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298 IARC MONOGRAPHS VOLUME 82 Marti
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300 IARC MONOGRAPHS VOLUME 82 Sharm
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302 (d ) Solubility: Soluble in wat
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304 1.4 Occurrence Fumonisins have
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306 Table 1 (contd) IARC MONOGRAPHS
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308 (c) Formation in commodities ot
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312 IARC MONOGRAPHS VOLUME 82 3.1 O
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314 3.2.2 Rat IARC MONOGRAPHS VOLUM
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316 with NDEA and fumonisin B 1, wh
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318 IARC MONOGRAPHS VOLUME 82 In pi
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Figure 2. Allometric relationship b
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322 IARC MONOGRAPHS VOLUME 82 obser
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324 IARC MONOGRAPHS VOLUME 82 Hepat
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326 4.2.3 Related studies IARC MONO
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328 4.3.2 Experimental systems IARC
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330 and litters on postnatal day 21
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Table 4. Genetic and related effect
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334 IARC MONOGRAPHS VOLUME 82 The f
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336 IARC MONOGRAPHS VOLUME 82 (d )
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338 IARC MONOGRAPHS VOLUME 82 treat
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340 4.5.2 Interference with fatty a
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342 IARC MONOGRAPHS VOLUME 82 Figur
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344 5.2 Human carcinogenicity data
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346 IARC MONOGRAPHS VOLUME 82 Alber
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348 IARC MONOGRAPHS VOLUME 82 Chamb
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350 IARC MONOGRAPHS VOLUME 82 Floss
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352 IARC MONOGRAPHS VOLUME 82 Hiroo
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354 IARC MONOGRAPHS VOLUME 82 Lee,
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356 IARC MONOGRAPHS VOLUME 82 Mobio
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358 IARC MONOGRAPHS VOLUME 82 Prelu
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360 IARC MONOGRAPHS VOLUME 82 Savar
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362 IARC MONOGRAPHS VOLUME 82 Steve
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364 IARC MONOGRAPHS VOLUME 82 Flett
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366 IARC MONOGRAPHS VOLUME 82 Yu, C
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368 disulfide, carbon tetrachloride
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Table 1 (contd) Sample matrix Sampl
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Table 3. Naphthalene production (th
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374 1.4 Occurrence 1.4.1 Natural oc
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Table 5. Occupational exposure to n
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378 water assuming a water concentr
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380 (Scheepers & Bos, 1992). The av
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382 (d ) Biodegradation Studies on
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386 3.2 Inhalation exposure 3.2.1 M
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388 3.3.2 Rat Ten BD I and BD III r
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Figure 1. Main metabolic pathways o
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392 IARC MONOGRAPHS VOLUME 82 and t
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394 IARC MONOGRAPHS VOLUME 82 and 1
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396 IARC MONOGRAPHS VOLUME 82 1-240
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398 IARC MONOGRAPHS VOLUME 82 Perfu
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400 Siegel and Wason (1986) reviewe
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402 IARC MONOGRAPHS VOLUME 82 liver
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404 IARC MONOGRAPHS VOLUME 82 to id
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406 IARC MONOGRAPHS VOLUME 82 Alkal
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408 hyperplasia, atrophy, chronic i
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410 had deficient glucose-6-phospha
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Table 10. Genetic and related effec
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Table 10 (contd) Test system Micron
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416 assay with or without metabolic
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418 There is some evidence of devel
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420 IARC MONOGRAPHS VOLUME 82 Bjør
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422 IARC MONOGRAPHS VOLUME 82 Conkl
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424 IARC MONOGRAPHS VOLUME 82 Envir
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426 IARC MONOGRAPHS VOLUME 82 Ho, C
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428 IARC MONOGRAPHS VOLUME 82 Lynch
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430 IARC MONOGRAPHS VOLUME 82 O’B
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432 IARC MONOGRAPHS VOLUME 82 Schee
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434 IARC MONOGRAPHS VOLUME 82 Versc
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STYRENE This substance was consider
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EPA Method 8260B can be used to det
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Styrene is produced mainly by catal
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STYRENE 443 Table 3. Use patterns f
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STYRENE 445 most samples taken from
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STYRENE 447 successive layers of ch
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Table 4 (contd) Country and year of
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Table 5. Biological monitoring of o
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STYRENE 453 Since 1990, the long-te
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same products resulted in exposures
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STYRENE 457 Ambient air monitoring
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200 μg/kg, although 77% of the foo
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Table 8 (contd) Country or region Y
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2.1 Case reports 2. Studies of Canc
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Table 10 (contd) Reference (country
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Table 10 (contd) Reference (country
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STYRENE 469 (95% CI, 1.4-5.2; 10 de
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who had been employed in 1964-70 (t
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elationship for styrene became nega
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atio, 4.4; 95% CI, 1.1-17 in multip
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controls versus 32/32 treated). No
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3.4 Intraperitoneal administration
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Figure 1. Main metabolic pathways f
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STYRENE 483 a maximum and averaged
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(b) Distribution STYRENE 485 An ear
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STYRENE 487 rats with phenobarbital
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STYRENE 489 gavage (100-350 mg/kg b
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CYP2E1 and CYP2F2) inhibited nasal
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model indicated that absorbed styre
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female workers in the glass fibre-r
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STYRENE 497 continuously for seven
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STYRENE 499 exposure concentrations
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STYRENE 501 The frequency of sponta
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STYRENE 503 groups. Only minor gene
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concentrations of styrene in air we
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Table 12. Cytogenetic studies in ly
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Table 13. Genetic and related effec
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(b) Experimental systems (see Table
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Table 14 (contd) Test system Result
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STYRENE 515 styrene 7,8-oxide. Joha
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Styrene 7,8-oxide can bind to DNA w
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STYRENE 519 a small and non-signifi
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STYRENE 521 and immune systems, liv
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STYRENE 523 Artuso, M., Angotzi, G.
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STYRENE 525 Brugnone, F., Perbellin
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STYRENE 527 Coccini, T., Maestri, L
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STYRENE 529 Edling, C., Anundi, H.,
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STYRENE 531 Gobba, F., Galassi, C.,
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STYRENE 533 Horvath, E., Pongracz,
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STYRENE 535 logical Study and the I
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STYRENE 537 Linhart, I., Gut, I.,
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STYRENE 539 Miller, S.L., Branoff,
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STYRENE 541 Newhook, R. & Caldwell,
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STYRENE 543 Pryor, G.T., Rebert, C.
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STYRENE 545 Sielken, R.L. & Valdez-
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STYRENE 547 Tsuda, S., Matsusaka, N
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STYRENE 549 Boffetta, P. (1996b) Ex
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Agent SUMMARY OF FINAL EVALUATIONS
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554 IARC MONOGRAPHS VOLUME 82 DGAL:
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556 IARC MONOGRAPHS VOLUME 82 PMTDI
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558 IARC MONOGRAPHS VOLUME 82 Aldri
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560 IARC MONOGRAPHS VOLUME 82 Benz[
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562 β-Butyrolactone 11, 225 (1976)
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564 IARC MONOGRAPHS VOLUME 82 Chlor
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566 Cyproterone acetate 72, 49 (199
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568 IARC MONOGRAPHS VOLUME 82 Diepo
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570 Ethionamide 13, 83 (1977); Supp
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572 IARC MONOGRAPHS VOLUME 82 Haema
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574 L Lasiocarpine 10, 281 (1976);
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576 IARC MONOGRAPHS VOLUME 82 Methy
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578 IARC MONOGRAPHS VOLUME 82 Nicke
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580 O Ochratoxin A 10, 191 (1976);
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582 IARC MONOGRAPHS VOLUME 82 Polyb
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584 Rhodamine 6G 16, 233 (1978); Su
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586 Sulfafurazole 24, 275 (1980); S
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588 1,1,1-Trichloroethane 20, 515 (
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590 Y Yellow AB 8, 279 (1975); Supp
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Volume 31 Some Food Additives, Feed
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